Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath

Omura, Akiisa; Kimura, Toru; Maniwa, Tomohiro et al.

Surgery Today, 2025, 155380

Number of Access:911（2025-07-28 20:30 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101012

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Title
Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
Creator
CreatorName
Omura, Akiisa
NRID
1000090580796 1000090580796
ORCID
0000-0003-4504-232X 0000-0003-4504-232X
researchmap permalink
toru_kimura toru_kimura
CreatorName
Kimura, Toru
CreatorName
Maniwa, Tomohiro
NRID
1000090648932 1000090648932
ORCID
0000-0001-8658-2395 0000-0001-8658-2395
researchmap permalink
twosaka2018 twosaka2018
Scopus Author ID
57421862900 57421862900
CreatorName
Watabe, Tadashi
NRID
1000020505945 1000020505945
CreatorName
Honma, Keiichiro
NRID
1000090572983 1000090572983
researchmap permalink
shintani6384 shintani6384
Scopus Author ID
7103142734 7103142734
CreatorName
Shintani, Yasushi
NRID
1000040538857 1000040538857
CreatorName
Okami, Jiro
Subject
Diagnostic target
Fibroblast activation protein
Malignant potential
Pleural tumor
Solitary fibrous tumor
Description
The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: https://doi.org/10.1007/s00595-025-03024-y
Abstract
Purpose: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs. Methods: The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath. Results: Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP. Conclusion: Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.
Publisher
Springer
Source Title
Surgery Today
Page
155380
Date of Issued
2025-03-24
Language
English
Handle URL
https://hdl.handle.net/11094/101012
PISSN
09411291
eISSN
14362813
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s00595-025-03024-y
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article