Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury

Ito, Hiroshi; Ebihara, Takeshi; Matsumoto, Hisatake et al.

Scientific Reports, 2025, 15(1), 2470

Number of Access:824（2025-08-16 03:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101050

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Title
Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury
Creator
NRID
1000080836594 1000080836594
researchmap permalink
1009hiroshi.ito 1009hiroshi.ito
CreatorName
Ito, Hiroshi
NRID
1000010813975 1000010813975
ORCID
0000-0003-4101-0419 0000-0003-4101-0419
researchmap permalink
ebihara830 ebihara830
CreatorName
Ebihara, Takeshi
NRID
1000070644003 1000070644003
researchmap permalink
38283828 38283828
Scopus Author ID
36632584800 36632584800
CreatorName
Matsumoto, Hisatake
NRID
1000060459500 1000060459500
ORCID
0000-0002-8254-3716 0000-0002-8254-3716
researchmap permalink
read0068529 read0068529
Scopus Author ID
56210537000 56210537000
CreatorName
Oda, Jun
Subject
Growth differentiation factor 15
Sequential organ failure assessment score
Traumatic brain injury
Description
Ito H., Ebihara T., Matsumoto H., et al. Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury. Scientific Reports 15, 2470 (2025); https://doi.org/10.1038/s41598-025-87062-z.
Abstract
Circulating growth differentiation factor 15 (GDF-15) increases in response to inflammation and tissue damage. Its association with functional prognosis in cerebral infarction and subarachnoid hemorrhage is established; however, its role in traumatic brain injury (TBI) and its relationship with Sequential Organ Failure Assessment (SOFA) score, an indicator of systemic organ damage in TBI, remains unclear. This study aimed to explore the correlation between GDF-15 and functional outcomes at discharge in patients with TBI and stroke, including its association with SOFA scores in TBI. Patients with cerebral infarction, subarachnoid hemorrhage, and TBI transported within 24 h from July 2020 to August 2022 were included. Multivariable logistic regression analyzed the relationship between GDF-15 levels at admission and functional outcomes at discharge, with age and sex as covariates. Additionally, correlations between GDF-15 levels and SOFA scores were assessed. Multivariable logistic regression showed a relationship between GDF-15 levels at admission and functional outcomes at discharge in cerebral infarction and subarachnoid hemorrhage but not in TBI. In TBI cases, GDF-15 correlated with SOFA scores, indicating its potential as a TBI severity marker. Although functional prognosis at discharge was evaluated, long-term outcomes were not clear, and this will be addressed in future research.
Publisher
Nature Research
Source Title
Scientific Reports
Volume (Issue)
15(1)
Page
2470
Date of Issued
2025-01-20
Language
English
Handle URL
https://hdl.handle.net/11094/101050
eISSN
20452322
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/s41598-025-87062-z
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article