Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties

Seo, Yeongjun; Nawa, Shiori; Goto, Tomoyo; Cho, Sunghun; Sekino, Tohru

doi:https://doi.org/10.1038/s41598-025-85116-w

Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties

Seo, Yeongjun; Nawa, Shiori; Goto, Tomoyo et al.

Scientific Reports, 2025, 15(1), 2479

Number of Access:533（2025-08-14 15:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101072

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Title	Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties
Creator	NRID 1000060943610 1000060943610 researchmap permalink yjseo yjseo Scopus Author ID 57217854207 57217854207 ORCID 0009-0007-5668-5933 0009-0007-5668-5933 CreatorName Seo, Yeongjun
	CreatorName Nawa, Shiori
	NRID 1000060643682 1000060643682 ORCID 0000-0003-1362-6750 0000-0003-1362-6750 researchmap permalink read0144508 read0144508 Scopus Author ID 48861284000 48861284000 CreatorName Goto, Tomoyo
	NRID 1000050776135 1000050776135 ORCID 0000-0002-6254-1094 0000-0002-6254-1094 researchmap permalink shcho shcho Scopus Author ID 57104081400 57104081400 CreatorName Cho, Sunghun
	NRID 1000020226658 1000020226658 ORCID 0000-0002-6605-9166 0000-0002-6605-9166 researchmap permalink tohrusekino tohrusekino Scopus Author ID 7006706950 7006706950 CreatorName Sekino, Tohru
Subject	Biomineralization, Cold sintering process
	Hydroxyapatite
	Low-temperature sintering
	Mechanical properties
	Zirconia
Description	Seo Y., Nawa S., Goto T., et al. Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties. Scientific Reports 15, 2479 (2025); https://doi.org/10.1038/s41598-025-85116-w.
Abstract	Hydroxyapatite/zirconia (HAP/ZrO2) composites were fabricated via the low-temperature mineralization sintering process (LMSP) at an extremely low temperature of 130 °C to enhance the mechanical properties of HAP and broaden its practical applications. For this purpose, 5–20 vol% calcia-stabilized ZrO2 were introduced into HAP, and HAP/ZrO2 nanoparticles, mixed with simulated body fluid, were densified under a uniaxial pressure of 800 MPa at 130 °C. At 10 vol% ZrO2, the relative density of the HAP/ZrO2 composite was determined to be 88.3 ± 1.1%. Additionally, it exhibited the highest values of mechanical properties such as the Vickers hardness (3.68 ± 0.18 GPa), fracture toughness (1.11 ± 0.10 MPa·m1/2), biaxial flexural strength (63.72 ± 2.35 MPa), and Young’s modulus (83.91 ± 1.93 GPa) among the composite samples. These values were considerably higher than those of the pure HAP matrix due to the adequate reinforcement by ZrO2 nanoparticles. Notably, owing to the low sintering temperature, phase decomposition of HAP, normally observed at high sintering temperatures above 1200 °C, was not observed. These results suggest that LMSP enables the incorporation of reinforcing ceramic materials with high sintering temperatures into bioactive materials at significantly lower temperatures, thereby improving their properties.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	15(1)
Page	2479
Date of Issued	2025-01-20
Language	English
Handle URL	https://hdl.handle.net/11094/101072
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-025-85116-w
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15(1), p. 2479
DC.title	Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties
DC.creator	Seo, Yeongjun
	Nawa, Shiori
	Goto, Tomoyo
	Cho, Sunghun
	Sekino, Tohru
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-01-20
DC.identifier	https://doi.org/10.1038/s41598-025-85116-w
DC.subject	Biomineralization, Cold sintering process
	Hydroxyapatite
	Low-temperature sintering
	Mechanical properties
	Zirconia
DC.description	Seo Y., Nawa S., Goto T., et al. Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties. Scientific Reports 15, 2479 (2025); https://doi.org/10.1038/s41598-025-85116-w.
DCTERMS.abstract	Hydroxyapatite/zirconia (HAP/ZrO2) composites were fabricated via the low-temperature mineralization sintering process (LMSP) at an extremely low temperature of 130 °C to enhance the mechanical properties of HAP and broaden its practical applications. For this purpose, 5–20 vol% calcia-stabilized ZrO2 were introduced into HAP, and HAP/ZrO2 nanoparticles, mixed with simulated body fluid, were densified under a uniaxial pressure of 800 MPa at 130 °C. At 10 vol% ZrO2, the relative density of the HAP/ZrO2 composite was determined to be 88.3 ± 1.1%. Additionally, it exhibited the highest values of mechanical properties such as the Vickers hardness (3.68 ± 0.18 GPa), fracture toughness (1.11 ± 0.10 MPa·m1/2), biaxial flexural strength (63.72 ± 2.35 MPa), and Young’s modulus (83.91 ± 1.93 GPa) among the composite samples. These values were considerably higher than those of the pure HAP matrix due to the adequate reinforcement by ZrO2 nanoparticles. Notably, owing to the low sintering temperature, phase decomposition of HAP, normally observed at high sintering temperatures above 1200 °C, was not observed. These results suggest that LMSP enables the incorporation of reinforcing ceramic materials with high sintering temperatures into bioactive materials at significantly lower temperatures, thereby improving their properties.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	101072
citation_title	Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties
citation_author	Seo, Yeongjun
	Nawa, Shiori
	Goto, Tomoyo
	Cho, Sunghun
	Sekino, Tohru
citation_publisher	Nature Research
citation_language	English
citation_date	2025-01-20
citation_journal_title	Scientific Reports
citation_volume	15
citation_issue	1
citation_firstpage	2479
citation_doi	https://doi.org/10.1038/s41598-025-85116-w
citation_public_url	https://hdl.handle.net/11094/101072

Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties

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