Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis

Uemura, Keisuke; Kono, Sotaro; Takashima, Kazuma; Tamura, Kazunori; Higuchi, Ryo; Mae, Hirokazu; Nakamura, Nobuo; Otake, Yoshito; Sato, Yoshinobu; Sugano, Nobuhiko; Okada, Seiji; Hamada, Hidetoshi

doi:https://doi.org/10.1016/j.bone.2025.117456

Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis

Uemura, Keisuke; Kono, Sotaro; Takashima, Kazuma et al.

Bone, 2025, 195, 117456

Number of Access:970（2025-07-18 17:14 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101104

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Title	Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis
Creator	NRID 1000070871367 1000070871367 ORCID 0000-0002-9245-1743 0000-0002-9245-1743 researchmap permalink keisukeuemura keisukeuemura Scopus Author ID 57203910709 57203910709 CreatorName Uemura, Keisuke
	ORCID 0009-0008-8393-2781 0009-0008-8393-2781 CreatorName Kono, Sotaro
	NRID 1000010964801 1000010964801 researchmap permalink tk-sm tk-sm CreatorName Takashima, Kazuma
	CreatorName Tamura, Kazunori
	CreatorName Higuchi, Ryo
	NRID 1000060978261 1000060978261 ORCID 0009-0000-4617-0409 0009-0000-4617-0409 CreatorName Mae, Hirokazu
	CreatorName Nakamura, Nobuo
	NRID 1000080349563 1000080349563 CreatorName Otake, Yoshito
	NRID 1000070243219 1000070243219 CreatorName Sato, Yoshinobu
	NRID 1000070273620 1000070273620 researchmap permalink read0185092 read0185092 Scopus Author ID 7101688414 7101688414 CreatorName Sugano, Nobuhiko
	NRID 1000030448435 1000030448435 ORCID 0000-0002-5107-8209 0000-0002-5107-8209 researchmap permalink okadaseiji okadaseiji Scopus Author ID 35079139100 35079139100 CreatorName Okada, Seiji
	NRID 1000090778705 1000090778705 ORCID 0000-0003-3652-9400 0000-0003-3652-9400 researchmap permalink x_y_z x_y_z Scopus Author ID 55917324800 55917324800 CreatorName Hamada, Hidetoshi
Subject	Artificial intelligence
	Deep learning
	Discordance
	Divergence
	DXA
	Quantitative computed tomography
Description	Uemura K., Kono S., Takashima K., et al. Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis. Bone 195, 117456 (2025); https://doi.org/10.1016/j.bone.2025.117456.
Abstract	Background: Accurately evaluating bone mineral density (BMD) in patients with unilateral hip osteoarthritis (OA) is crucial for diagnosing osteoporosis and selecting implants for hip arthroplasty. Our goal was to measure the BMD differences between sides, examine contributing factors, and identify the optimal side for BMD assessment in these patients. Methods: We analyzed 108 women with unilateral hip OA. Bilateral hip BMD was assessed automatically through quantitative CT (QCT) utilizing a validated, deep-learning-based approach. We evaluated BMD variations between the OA and healthy hips across total, neck, and distal regions. To determine their contributions, we analyzed factors, including patient demographics, Crowe classification, Bombelli classification, knee OA status, hip functional score, and gluteal muscle volume and density. Furthermore, we examined how side-to-side BMD differences influenced osteoporosis diagnosis using T-scores based on QCT. Results: The average BMD on the OA side was 6.9 % lower in the total region, 14.5 % higher in the neck region, and 9.4 % lower in the distal region than on the healthy side. Contributing factors to the reduced BMD in the OA hip included younger age, Bombelli classification (atrophic type), and significant gluteal muscle atrophy. Diagnoses from the OA side revealed lower sensitivity (61 %) than those from the healthy side (88 %). Conclusions: Analysis on one side alone yields a more precise osteoporosis diagnosis from the healthy side. Nonetheless, bilateral BMD assessment remains crucial, particularly in younger individuals and those with atrophic OA types. Although based on QCT, our findings support bilateral analysis by dual-energy X-ray absorptiometry for these patients.
Publisher	Elsevier Inc.
Source Title	Bone
Volume (Issue)	195
Page	117456
Date of Issued	2025-03-09
Language	English
Handle URL	https://hdl.handle.net/11094/101104
PISSN	87563282
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bone.2025.117456
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Bone. 2025, 195, p. 117456
DC.title	Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis
DC.creator	Uemura, Keisuke
	Kono, Sotaro
	Takashima, Kazuma
	Tamura, Kazunori
	Higuchi, Ryo
	Mae, Hirokazu
	Nakamura, Nobuo
	Otake, Yoshito
	Sato, Yoshinobu
	Sugano, Nobuhiko
	Okada, Seiji
	Hamada, Hidetoshi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-09
DC.identifier	https://doi.org/10.1016/j.bone.2025.117456
DC.subject	Artificial intelligence
	Deep learning
	Discordance
	Divergence
	DXA
	Quantitative computed tomography
DC.description	Uemura K., Kono S., Takashima K., et al. Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis. Bone 195, 117456 (2025); https://doi.org/10.1016/j.bone.2025.117456.
DCTERMS.abstract	Background: Accurately evaluating bone mineral density (BMD) in patients with unilateral hip osteoarthritis (OA) is crucial for diagnosing osteoporosis and selecting implants for hip arthroplasty. Our goal was to measure the BMD differences between sides, examine contributing factors, and identify the optimal side for BMD assessment in these patients. Methods: We analyzed 108 women with unilateral hip OA. Bilateral hip BMD was assessed automatically through quantitative CT (QCT) utilizing a validated, deep-learning-based approach. We evaluated BMD variations between the OA and healthy hips across total, neck, and distal regions. To determine their contributions, we analyzed factors, including patient demographics, Crowe classification, Bombelli classification, knee OA status, hip functional score, and gluteal muscle volume and density. Furthermore, we examined how side-to-side BMD differences influenced osteoporosis diagnosis using T-scores based on QCT. Results: The average BMD on the OA side was 6.9 % lower in the total region, 14.5 % higher in the neck region, and 9.4 % lower in the distal region than on the healthy side. Contributing factors to the reduced BMD in the OA hip included younger age, Bombelli classification (atrophic type), and significant gluteal muscle atrophy. Diagnoses from the OA side revealed lower sensitivity (61 %) than those from the healthy side (88 %). Conclusions: Analysis on one side alone yields a more precise osteoporosis diagnosis from the healthy side. Nonetheless, bilateral BMD assessment remains crucial, particularly in younger individuals and those with atrophic OA types. Although based on QCT, our findings support bilateral analysis by dual-energy X-ray absorptiometry for these patients.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	101104
citation_title	Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis
citation_author	Uemura, Keisuke
	Kono, Sotaro
	Takashima, Kazuma
	Tamura, Kazunori
	Higuchi, Ryo
	Mae, Hirokazu
	Nakamura, Nobuo
	Otake, Yoshito
	Sato, Yoshinobu
	Sugano, Nobuhiko
	Okada, Seiji
	Hamada, Hidetoshi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2025-03-09
citation_journal_title	Bone
citation_volume	195
citation_firstpage	117456
citation_doi	https://doi.org/10.1016/j.bone.2025.117456
citation_public_url	https://hdl.handle.net/11094/101104

Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis

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