Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle

Satomura, Hiroki; Kimura, Yasushi; Nakamura, Masahisa; Tomotake, Kosuke; Yamamoto, Koki; Tanaka, Kaishu; Ono, Yusuke; Higashihara, Hiroki; Tomiyama, Noriyuki

doi:https://doi.org/10.1007/s00261-025-04904-0

Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle

Satomura, Hiroki; Kimura, Yasushi; Nakamura, Masahisa et al.

Abdominal Radiology, 2025

Number of Access:930（2025-07-27 09:12 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101113

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Title	Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle
Creator	CreatorName Satomura, Hiroki
	NRID 1000080774223 1000080774223 researchmap permalink kimurayasushi kimurayasushi CreatorName Kimura, Yasushi
	CreatorName Nakamura, Masahisa
	CreatorName Tomotake, Kosuke
	CreatorName Yamamoto, Koki
	NRID 1000050839701 1000050839701 researchmap permalink ushuika- ushuika- Scopus Author ID 55311437600 55311437600 CreatorName Tanaka, Kaishu
	NRID 1000090816901 1000090816901 researchmap permalink y-ono y-ono Scopus Author ID 56406831000 56406831000 CreatorName Ono, Yusuke
	NRID 1000090423186 1000090423186 researchmap permalink hiroki-portal hiroki-portal Scopus Author ID 13605077500 13605077500 CreatorName Higashihara, Hiroki
	NRID 1000050294070 1000050294070 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
Subject	Coaxial introducer needle
	Core needle biopsy
	Image-guided biopsy
	Percutaneous biopsy
Description	The version of record of this article, first published in Radiological Physics and Technology, is available online at Publisher’s website: https://doi.org/10.1007/s00261-025-04904-0.
Abstract	Purpose: This study evaluated the efficacy of a modified core needle biopsy using a 2 cm stroke length to improve tissue yield for molecular analyses in cancer genomics medicine. Methods: In vitro biopsy weight evaluations were performed using agarose gels of varying hardness. Ex vivo biopsy weight evaluations were conducted using chicken liver, gizzard, breast, and pork loin tissues. Furthermore, in vivo experiments were performed using murine subcutaneous tumor models. The modified method involved using a coaxial introducer needle to maintain a 1 cm notch length while employing a 2 cm stroke length to increase tissue yield. Biopsy performance parameters, including sample weight and DNA yield, were compared between the modified and conventional methods. The firing speed of the biopsy needles with 1 cm and 2 cm stroke lengths was also measured using a high-speed camera. Results: The modified technique significantly increased the sample volume across all agarose gel concentrations (9.5–13% increase, P < 0.05). Ex vivo tests revealed significantly higher tissue yields in most samples, except for chicken gizzards. In vivo, the modified method produced significantly larger tissue samples (4.6 mg vs. 2.9 mg, P < 0.001) and higher DNA yield (8.2 ng vs. 6.9 ng, P < 0.05). In addition, the biopsy needle’s firing speed was 1.4–1.8 times faster with the 2 cm stroke length than 1 cm stroke. Conclusion: The modified biopsy technique using a 2 cm stroke length significantly improved tissue yield, enhancing the quality of biopsy samples for molecular analyses in precision medicine.
Publisher	Springer
Source Title	Abdominal Radiology
Date of Issued	2025-03-29
Language	English
Handle URL	https://hdl.handle.net/11094/101113
PISSN	2366004X
eISSN	23660058
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00261-025-04904-0
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Abdominal Radiology. 2025
DC.title	Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle
DC.creator	Satomura, Hiroki
	Kimura, Yasushi
	Nakamura, Masahisa
	Tomotake, Kosuke
	Yamamoto, Koki
	Tanaka, Kaishu
	Ono, Yusuke
	Higashihara, Hiroki
	Tomiyama, Noriyuki
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-03-29
DC.identifier	https://doi.org/10.1007/s00261-025-04904-0
DC.subject	Coaxial introducer needle
	Core needle biopsy
	Image-guided biopsy
	Percutaneous biopsy
DC.description	The version of record of this article, first published in Radiological Physics and Technology, is available online at Publisher’s website: https://doi.org/10.1007/s00261-025-04904-0.
DCTERMS.abstract	Purpose: This study evaluated the efficacy of a modified core needle biopsy using a 2 cm stroke length to improve tissue yield for molecular analyses in cancer genomics medicine. Methods: In vitro biopsy weight evaluations were performed using agarose gels of varying hardness. Ex vivo biopsy weight evaluations were conducted using chicken liver, gizzard, breast, and pork loin tissues. Furthermore, in vivo experiments were performed using murine subcutaneous tumor models. The modified method involved using a coaxial introducer needle to maintain a 1 cm notch length while employing a 2 cm stroke length to increase tissue yield. Biopsy performance parameters, including sample weight and DNA yield, were compared between the modified and conventional methods. The firing speed of the biopsy needles with 1 cm and 2 cm stroke lengths was also measured using a high-speed camera. Results: The modified technique significantly increased the sample volume across all agarose gel concentrations (9.5–13% increase, P < 0.05). Ex vivo tests revealed significantly higher tissue yields in most samples, except for chicken gizzards. In vivo, the modified method produced significantly larger tissue samples (4.6 mg vs. 2.9 mg, P < 0.001) and higher DNA yield (8.2 ng vs. 6.9 ng, P < 0.05). In addition, the biopsy needle’s firing speed was 1.4–1.8 times faster with the 2 cm stroke length than 1 cm stroke. Conclusion: The modified biopsy technique using a 2 cm stroke length significantly improved tissue yield, enhancing the quality of biopsy samples for molecular analyses in precision medicine.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	101113
citation_title	Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle
citation_author	Satomura, Hiroki
	Kimura, Yasushi
	Nakamura, Masahisa
	Tomotake, Kosuke
	Yamamoto, Koki
	Tanaka, Kaishu
	Ono, Yusuke
	Higashihara, Hiroki
	Tomiyama, Noriyuki
citation_publisher	Springer
citation_language	English
citation_date	2025-03-29
citation_journal_title	Abdominal Radiology
citation_doi	https://doi.org/10.1007/s00261-025-04904-0
citation_public_url	https://hdl.handle.net/11094/101113

Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle

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