Heritability of bone mineral density among Japanese women: A twin study

Saeki, Soichiro; Tomizawa, Rie; Minamitani, Kaori et al.

Maturitas, 2025, 196, 108251

Number of Access:365（2025-12-03 11:54 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101345

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Title
Heritability of bone mineral density among Japanese women: A twin study
Creator
CreatorName
Saeki, Soichiro
NRID
1000020584551 1000020584551
CreatorName
Tomizawa, Rie
NRID
1000000571423 1000000571423
CreatorName
Minamitani, Kaori
NRID
1000000283747 1000000283747
researchmap permalink
ken-nakata ken-nakata
Scopus Author ID
7402151308 7402151308
CreatorName
Nakata, Ken
NRID
1000040625498 1000040625498
CreatorName
Honda, Chika
Subject
Bone fractures
Bone mineral density
Heritability
Osteoporosis
Prevention
Race and ethnicity
Description
Saeki S., Tomizawa R., Minamitani K., et al. Heritability of bone mineral density among Japanese women: A twin study. Maturitas 196, 108251 (2025); https://doi.org/10.1016/j.maturitas.2025.108251.
Abstract
Background: Osteoporosis is a major risk factor for fractures among the older population. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored. Therefore, we conducted a twin study among Japanese women to determine the extent of genetic and environmental influences on bone mineral density. Methods: The bone area ratio of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density. Results: The heritability of bone mineral density for the entire cohort was 0.51 (95 % confidence interval 0.38–0.63). For the women younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the additive genetics and unique environment (AE) model, with a heritability estimate of 0.53 (95 % confidence interval 0.34–0.72). Conclusions: Compared with women from other countries, Japanese women appear to have a lower heritability of bone mineral density. Consequently, environmental factors may exert a larger influence on osteoporosis among Japanese women than among women of other races and ethnicities.
Publisher
Elsevier Ireland Ltd
Source Title
Maturitas
Volume (Issue)
196
Page
108251
Date of Issued
2025-03-27
Language
English
Handle URL
https://hdl.handle.net/11094/101345
PISSN
03785122
eISSN
18734111
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1016/j.maturitas.2025.108251
Access Rights
embargoed access
CopyRight
© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 27 March 2026 in accordance with the publisher's policy.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article