Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement

Kosugi, Shumpei; Mizote, Isamu; Nakamura, Daisuke; Sugae, Hiroki; Matsuhiro, Yutaka; Okuno, Shota; Kawamura, Ai; Yamashita, Kizuku; Maeda, Koichi; Shimamura, Kazuo; Dohi, Tomoharu; Takeda, Yasuharu; Sakata, Yasushi

doi:https://doi.org/10.1002/ccd.31537

Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement

Kosugi, Shumpei; Mizote, Isamu; Nakamura, Daisuke et al.

Catheterization and Cardiovascular Interventions, 2025

Number of Access:708（2025-07-18 09:58 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101401

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
CatheterCardiovascInterventions	pdf	None	680 KB	8	2025.06.03

Creative Commons : Attribution - NonCommercial - NoDerivatives

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement
Creator	ORCID 0000-0002-0274-5052 0000-0002-0274-5052 CreatorName Kosugi, Shumpei
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 CreatorName Mizote, Isamu
	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 CreatorName Nakamura, Daisuke
	CreatorName Sugae, Hiroki
	ORCID 0000-0002-5229-6857 0000-0002-5229-6857 CreatorName Matsuhiro, Yutaka
	researchmap permalink okunoshota okunoshota CreatorName Okuno, Shota
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 CreatorName Kawamura, Ai
	NRID 1000060778661 1000060778661 researchmap permalink ky_osaka-u_2020 ky_osaka-u_2020 Scopus Author ID 57188740592 57188740592 CreatorName Yamashita, Kizuku
	NRID 1000050644994 1000050644994 researchmap permalink koichi-maeda koichi-maeda Scopus Author ID 55318832600 55318832600 CreatorName Maeda, Koichi
	NRID 1000010507205 1000010507205 researchmap permalink kazuo-shimamura kazuo-shimamura Scopus Author ID 35969640700 35969640700 CreatorName Shimamura, Kazuo
	NRID 1000090838137 1000090838137 researchmap permalink dohi_1230 dohi_1230 Scopus Author ID 35071263000 35071263000 CreatorName Dohi, Tomoharu
	NRID 1000090572305 1000090572305 researchmap permalink takeda14 takeda14 Scopus Author ID 35398343900 35398343900 CreatorName Takeda, Yasuharu
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	aortic stenosis
	brain natriuretic peptide
	E/A ratio
	left ventricular filling pressure
	paravalvular regurgitation
	transcatheter aortic valve replacement
Description	Kosugi S., Mizote I., Nakamura D., et al. Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement. Catheterization and Cardiovascular Interventions (2025); https://doi.org/10.1002/ccd.31537.
Abstract	Background: Paravalvular regurgitation (PVR) following transcatheter aortic valve replacement (TAVR) is a complication linked to poor outcomes. The prognostic impact of mild PVR, particularly in patients with elevated preprocedural left ventricular (LV) filling pressure, remains uncertain. Aims: This study aimed to assess the influence of elevated preprocedural LV filling pressure on mild PVR prognosis following TAVR. Methods: This single-center, retrospective study analyzed consecutive patients with severe aortic stenosis who underwent TAVR, excluding those with moderate or severe PVR. Preprocedural LV filling pressure was evaluated using baseline E/A ratio, and patients were stratified into four groups based on E/A ratio (≤1 or >1) and PVR severity (none/trace or mild). The primary endpoint was cardiovascular death within 5 years. Results: Among 904 patients, 466 had E/A ≤ 1 with none/trace PVR, 92 had E/A > 1 with none/trace PVR, 300 had E/A ≤ 1 with mild PVR, and 46 had E/A > 1 with mild PVR. Multivariable analysis identified E/A > 1 with mild PVR as an independent predictor of cardiovascular death (adjusted hazard ratio [HR]: 2.38; 95% confidence interval [CI]: 1.28–4.42; p < 0.01). In contrast, E/A > 1 with none/trace PVR (HR: 1.16, 95% CI: 0.66–2.03) and E/A ≤ 1 with mild PVR (HR: 1.33, 95% CI: 0.89–2.00) were not significant predictors compared to E/A ≤ 1 with none/trace PVR. Conclusions: Elevated preprocedural LV filling pressure is independently associated with an increased risk of cardiovascular death in patients with mild PVR following TAVR.
Publisher	John Wiley and Sons Inc
Source Title	Catheterization and Cardiovascular Interventions
Date of Issued	2025-04-15
Language	English
Handle URL	https://hdl.handle.net/11094/101401
PISSN	15221946
eISSN	1522726X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/ccd.31537
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Catheterization and Cardiovascular Interventions. 2025
DC.title	Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement
DC.creator	Kosugi, Shumpei
	Mizote, Isamu
	Nakamura, Daisuke
	Sugae, Hiroki
	Matsuhiro, Yutaka
	Okuno, Shota
	Kawamura, Ai
	Yamashita, Kizuku
	Maeda, Koichi
	Shimamura, Kazuo
	Dohi, Tomoharu
	Takeda, Yasuharu
	Sakata, Yasushi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-04-15
DC.identifier	https://doi.org/10.1002/ccd.31537
DC.subject	aortic stenosis
	brain natriuretic peptide
	E/A ratio
	left ventricular filling pressure
	paravalvular regurgitation
	transcatheter aortic valve replacement
DC.description	Kosugi S., Mizote I., Nakamura D., et al. Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement. Catheterization and Cardiovascular Interventions (2025); https://doi.org/10.1002/ccd.31537.
DCTERMS.abstract	Background: Paravalvular regurgitation (PVR) following transcatheter aortic valve replacement (TAVR) is a complication linked to poor outcomes. The prognostic impact of mild PVR, particularly in patients with elevated preprocedural left ventricular (LV) filling pressure, remains uncertain. Aims: This study aimed to assess the influence of elevated preprocedural LV filling pressure on mild PVR prognosis following TAVR. Methods: This single-center, retrospective study analyzed consecutive patients with severe aortic stenosis who underwent TAVR, excluding those with moderate or severe PVR. Preprocedural LV filling pressure was evaluated using baseline E/A ratio, and patients were stratified into four groups based on E/A ratio (≤1 or >1) and PVR severity (none/trace or mild). The primary endpoint was cardiovascular death within 5 years. Results: Among 904 patients, 466 had E/A ≤ 1 with none/trace PVR, 92 had E/A > 1 with none/trace PVR, 300 had E/A ≤ 1 with mild PVR, and 46 had E/A > 1 with mild PVR. Multivariable analysis identified E/A > 1 with mild PVR as an independent predictor of cardiovascular death (adjusted hazard ratio [HR]: 2.38; 95% confidence interval [CI]: 1.28–4.42; p < 0.01). In contrast, E/A > 1 with none/trace PVR (HR: 1.16, 95% CI: 0.66–2.03) and E/A ≤ 1 with mild PVR (HR: 1.33, 95% CI: 0.89–2.00) were not significant predictors compared to E/A ≤ 1 with none/trace PVR. Conclusions: Elevated preprocedural LV filling pressure is independently associated with an increased risk of cardiovascular death in patients with mild PVR following TAVR.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	101401
citation_title	Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement
citation_author	Kosugi, Shumpei
	Mizote, Isamu
	Nakamura, Daisuke
	Sugae, Hiroki
	Matsuhiro, Yutaka
	Okuno, Shota
	Kawamura, Ai
	Yamashita, Kizuku
	Maeda, Koichi
	Shimamura, Kazuo
	Dohi, Tomoharu
	Takeda, Yasuharu
	Sakata, Yasushi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-04-15
citation_journal_title	Catheterization and Cardiovascular Interventions
citation_doi	https://doi.org/10.1002/ccd.31537
citation_public_url	https://hdl.handle.net/11094/101401

Impact of Elevated Preprocedural Left Ventricular Filling Pressure on Prognosis of Mild Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement

Link to primary information

Item Information

Show details