Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan

Gon, Yasufumi; Zha, Ling; Kawano, Tomohiro; Kudo, Haruka; Morishima, Toshitaka; Sasaki, Tsutomu; Miyashiro, Isao; Mochizuki, Hideki; Sobue, Tomotaka

doi:https://doi.org/10.1161/JAHA.124.037965

Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan

Gon, Yasufumi; Zha, Ling; Kawano, Tomohiro et al.

Journal of the American Heart Association, 2025, 14(10), e037965

Number of Access:474（2025-08-14 07:54 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101402

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Title	Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan
Creator	NRID 1000070751311 1000070751311 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 CreatorName Gon, Yasufumi
	researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 CreatorName Zha, Ling
	researchmap permalink tomohirokawano tomohirokawano CreatorName Kawano, Tomohiro
	CreatorName Kudo, Haruka
	NRID 1000010728893 1000010728893 researchmap permalink morishima morishima CreatorName Morishima, Toshitaka
	NRID 1000020534879 1000020534879 ORCID 0000-0001-8726-978X 0000-0001-8726-978X researchmap permalink tsutomusasaki1111 tsutomusasaki1111 Scopus Author ID 7407394272 7407394272 CreatorName Sasaki, Tsutomu
	CreatorName Miyashiro, Isao
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 CreatorName Mochizuki, Hideki
	NRID 1000050270674 1000050270674 CreatorName Sobue, Tomotaka
Description	Gon Yasufumi, Zha Ling, Kawano Tomohiro, et al. Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan. Journal of the American Heart Association 14, e037965 (2025); https://doi.org/10.1161/JAHA.124.037965.
Abstract	Background: Improvements in cancer survivorship have led to concern about cardiovascular disease (CVD) among cancer survivors. This study aimed to investigate CVD mortality in patients with cancer compared with the general population, with a focus on specific CVDs including ischemic heart disease, heart failure, aortic dissection, ischemic stroke, and hemorrhagic stroke. Methods: This nationwide population‐based cohort study used data from the National Cancer Registry in Japan. Patients diagnosed with cancer between January 2016 and December 2019 were included. Standardized mortality ratios (SMRs) and their 95% CIs were calculated to compare the risk of CVD mortality between patients with cancer and the general population. The SMRs were also computed for each specific CVD. Results: The study included 3 972 603 patients, representing 6 212 672 person‐years of follow‐up. Patients with cancer had a 2.39‐fold higher risk of cardiovascular death compared with the general population. The SMR was highest for nonlymphoid hematologic malignancies (4.32 [95% CI, 4.15–4.50]). The mortality risk varied across specific types of CVD. Nonlymphoid hematologic malignancies had the highest SMRs for ischemic heart disease (3.15 [95% CI, 2.87–3.45]) and heart failure (7.65 [95% CI, 7.07–8.27]). The SMR for aortic dissection, ischemic stroke, and hemorrhagic stroke were highest for laryngeal (3.31 [95% CI, 2.29–4.79]), pancreatic (5.39 [95% CI, 4.79–6.05]), and liver (3.75 [95% CI, 3.36–4.18]) cancers, respectively. Conclusions: Patients with cancer had a higher CVD mortality risk, which was prominent in nonlymphoid hematologic malignancies. The mortality risk varied considerably by cancer type and specific CVD type.
Publisher	Ovid Technologies (Wolters Kluwer Health)
Source Title	Journal of the American Heart Association
Volume (Issue)	14(10)
Page	e037965
Date of Issued	2025-05-15
Language	English
Handle URL	https://hdl.handle.net/11094/101402
eISSN	20479980
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1161/JAHA.124.037965
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of the American Heart Association. 2025, 14(10), p. e037965
DC.title	Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan
DC.creator	Gon, Yasufumi
	Zha, Ling
	Kawano, Tomohiro
	Kudo, Haruka
	Morishima, Toshitaka
	Sasaki, Tsutomu
	Miyashiro, Isao
	Mochizuki, Hideki
	Sobue, Tomotaka
DC.publisher	Ovid Technologies (Wolters Kluwer Health)
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-15
DC.identifier	https://doi.org/10.1161/JAHA.124.037965
DC.description	Gon Yasufumi, Zha Ling, Kawano Tomohiro, et al. Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan. Journal of the American Heart Association 14, e037965 (2025); https://doi.org/10.1161/JAHA.124.037965.
DCTERMS.abstract	Background: Improvements in cancer survivorship have led to concern about cardiovascular disease (CVD) among cancer survivors. This study aimed to investigate CVD mortality in patients with cancer compared with the general population, with a focus on specific CVDs including ischemic heart disease, heart failure, aortic dissection, ischemic stroke, and hemorrhagic stroke. Methods: This nationwide population‐based cohort study used data from the National Cancer Registry in Japan. Patients diagnosed with cancer between January 2016 and December 2019 were included. Standardized mortality ratios (SMRs) and their 95% CIs were calculated to compare the risk of CVD mortality between patients with cancer and the general population. The SMRs were also computed for each specific CVD. Results: The study included 3 972 603 patients, representing 6 212 672 person‐years of follow‐up. Patients with cancer had a 2.39‐fold higher risk of cardiovascular death compared with the general population. The SMR was highest for nonlymphoid hematologic malignancies (4.32 [95% CI, 4.15–4.50]). The mortality risk varied across specific types of CVD. Nonlymphoid hematologic malignancies had the highest SMRs for ischemic heart disease (3.15 [95% CI, 2.87–3.45]) and heart failure (7.65 [95% CI, 7.07–8.27]). The SMR for aortic dissection, ischemic stroke, and hemorrhagic stroke were highest for laryngeal (3.31 [95% CI, 2.29–4.79]), pancreatic (5.39 [95% CI, 4.79–6.05]), and liver (3.75 [95% CI, 3.36–4.18]) cancers, respectively. Conclusions: Patients with cancer had a higher CVD mortality risk, which was prominent in nonlymphoid hematologic malignancies. The mortality risk varied considerably by cancer type and specific CVD type.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	101402
citation_title	Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan
citation_author	Gon, Yasufumi
	Zha, Ling
	Kawano, Tomohiro
	Kudo, Haruka
	Morishima, Toshitaka
	Sasaki, Tsutomu
	Miyashiro, Isao
	Mochizuki, Hideki
	Sobue, Tomotaka
citation_publisher	Ovid Technologies (Wolters Kluwer Health)
citation_language	English
citation_date	2025-05-15
citation_journal_title	Journal of the American Heart Association
citation_volume	14
citation_issue	10
citation_firstpage	e037965
citation_doi	https://doi.org/10.1161/JAHA.124.037965
citation_public_url	https://hdl.handle.net/11094/101402

Specific Cardiovascular Mortality in Cancer Survivors: A Nationwide Population‐Based Cohort Study in Japan

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