Comparison of Spinal Cord Regeneration Capacity in Zebrafish and Medaka

Aoki, Shun; Hori, Masato; Zhang, Hanjie et al.

Neurochemical Research, 2025, 50, 153

Number of Access:310（2025-08-14 05:09 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/101410

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Title
Comparison of Spinal Cord Regeneration Capacity in Zebrafish and Medaka
Creator
CreatorName
Aoki, Shun
CreatorName
Hori, Masato
CreatorName
Zhang, Hanjie
NRID
1000020803505 1000020803505
ORCID
0000-0001-7484-4191 0000-0001-7484-4191
researchmap permalink
tsujioka tsujioka
Scopus Author ID
57188553938 57188553938
CreatorName
Tsujioka, Hiroshi
NRID
1000010301269 1000010301269
ORCID
0000-0003-4559-7018 0000-0003-4559-7018
researchmap permalink
ToshihideYamashita ToshihideYamashita
Scopus Author ID
35479670200 35479670200
CreatorName
Yamashita, Toshihide
Subject
Spinal cord regeneration
Zebrafish
Medaka
Cross-species comparison
RNA-seq
Description
The version of record of this article, first published in Neurochemical Research, is available online at Publisher’s website: https://doi.org/10.1007/s11064-025-04389-9.
Abstract
In mammals, spinal cord injury often results in permanent impairment of motor function owing to ineffective tissue regeneration. Unlike mammals, zebrafish have the remarkable ability to regenerate many tissues, including the spinal cord. Cross-species comparison is an attractive approach for revealing regeneration-specific mechanisms, but the large evolutionary distance between species sometimes hinders direct comparison. Recent studies have revealed that another model fish species, medaka, has a low regenerative ability in some tissues, making comparisons with them advantageous to revealing regeneration-specific mechanisms. However, their spinal cord regenerative ability has not been compared to other models. In this study, we functionally and histologically compared the spinal cord regeneration abilities of zebrafish and medaka. Swimming speed recovery was significantly lower in medaka than in zebrafish. Bridging of glia and neural tissue were thinner in medaka than in zebrafish. Axonal extension across the injured site was observed in zebrafish but not in medaka. Comparison of their gene expression profiles revealed genes involved in “Regeneration” were upregulated in zebrafish, whereas genes related to “Synaptic signaling” were downregulated in medaka. These results suggest that the ability to regenerate the spinal cord is lower in medaka than in zebrafish, making medaka an attractive model for revealing the mechanisms of spinal cord regeneration.
Publisher
Springer
Source Title
Neurochemical Research
Volume (Issue)
50
Page
153
Date of Issued
2025-04-25
Language
English
Handle URL
https://hdl.handle.net/11094/101410
PISSN
03643190
eISSN
15736903
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s11064-025-04389-9
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article