Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study

Shiraki, Tatsuya; Kioka, Hidetaka; Ueda-Hayakawa, Ikuko; Takahara, Mitsuyoshi; Tonomura, Kyoko; Maekawa, Aya; Kotobuki, Yorihisa; Enchi, Yukihiro; Ueda, Minako; Takahari, Kosuke; Takeda, Yasuharu; Nakamura, Daisuke; Mizote, Isamu; Ohtani, Tomohito; Fujimoto, Manabu; Sakata, Yasushi

doi:https://doi.org/10.1111/1346-8138.17783

Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study

Shiraki, Tatsuya; Kioka, Hidetaka; Ueda-Hayakawa, Ikuko et al.

Journal of Dermatology, 2025, 52(6), 1070-1077

Number of Access:141（2025-09-29 14:18 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102230

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Title	Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study
Creator	NRID 1000060784056 1000060784056 CreatorName Shiraki, Tatsuya
	NRID 1000070642099 1000070642099 researchmap permalink hkioka hkioka Scopus Author ID 36872909700 36872909700 CreatorName Kioka, Hidetaka
	NRID 1000080452100 1000080452100 researchmap permalink ikuko_ueda-hayakawa ikuko_ueda-hayakawa Scopus Author ID 26658779900 26658779900 CreatorName Ueda-Hayakawa, Ikuko
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	NRID 1000050869071 1000050869071 researchmap permalink kyokotonomura kyokotonomura Scopus Author ID 57206787887 57206787887 CreatorName Tonomura, Kyoko
	CreatorName Maekawa, Aya
	CreatorName Kotobuki, Yorihisa
	CreatorName Enchi, Yukihiro
	CreatorName Ueda, Minako
	CreatorName Takahari, Kosuke
	NRID 1000090572305 1000090572305 researchmap permalink takeda14 takeda14 Scopus Author ID 35398343900 35398343900 CreatorName Takeda, Yasuharu
	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 CreatorName Nakamura, Daisuke
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 CreatorName Mizote, Isamu
	NRID 1000030623897 1000030623897 researchmap permalink tohtani tohtani Scopus Author ID 57932819800 57932819800 CreatorName Ohtani, Tomohito
	NRID 1000090272591 1000090272591 ORCID 0000-0002-3062-4872 0000-0002-3062-4872 researchmap permalink read0122743 read0122743 Scopus Author ID 7401866712 7401866712 CreatorName Fujimoto, Manabu
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	anti-centromere antibody
	chronic limb-threatening ischemia
	computed tomography angiography
	immunoglobulin G
	left ventricular diastolic dysfunction
Description	Shiraki T., Kioka H., Ueda-Hayakawa I., et al. Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study. Journal of Dermatology 52(6), 1070-1077 (2025); https://doi.org/10.1111/1346-8138.17783.
Abstract	This cross-sectional pilot study investigated the clinical characteristics of anti-centromere antibody (ACA)–positive patients with below-the-knee arterial disease. Sixteen ACA-positive patients (mean age 69 ± 10 years; 94% women) underwent contrast-enhanced computed tomography evaluation, with arterial damage scored using the Global Limb Anatomic Staging System. Lower extremity arterial disease (LEAD) was defined as a below-the-knee arterial score ≥ 1 or > 50% stenosis in above-the-knee lesions. Eight patients were categorized into the LEAD group (below-the-knee arterial damage score 12 ± 6). The LEAD group showed significantly higher serum IgG1 levels (1029 ± 484 vs. 531 ± 72 mg/dL, p < 0.001) and a higher prevalence of diastolic dysfunction (62% vs. 0%, p = 0.026) compared to the non-LEAD group. Patients with diastolic dysfunction had significantly higher serum IgG1 levels than those without (1190 ± 559 vs. 593 ± 139 mg/dL, p = 0.008). These findings suggest associations between elevated serum IgG1 levels, below-the-knee arterial disease, and left ventricular diastolic dysfunction in ACA-positive patients.
Publisher	John Wiley and Sons Inc
Source Title	Journal of Dermatology
Volume (Issue)	52(6)
Page	1070-1077
Date of Issued	2025-05-16
Language	English
Handle URL	https://hdl.handle.net/11094/102230
PISSN	03852407
eISSN	13468138
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/1346-8138.17783
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Dermatology. 2025, 52(6), p. 1070-1077
DC.title	Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study
DC.creator	Shiraki, Tatsuya
	Kioka, Hidetaka
	Ueda-Hayakawa, Ikuko
	Takahara, Mitsuyoshi
	Tonomura, Kyoko
	Maekawa, Aya
	Kotobuki, Yorihisa
	Enchi, Yukihiro
	Ueda, Minako
	Takahari, Kosuke
	Takeda, Yasuharu
	Nakamura, Daisuke
	Mizote, Isamu
	Ohtani, Tomohito
	Fujimoto, Manabu
	Sakata, Yasushi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-16
DC.identifier	https://doi.org/10.1111/1346-8138.17783
DC.subject	anti-centromere antibody
	chronic limb-threatening ischemia
	computed tomography angiography
	immunoglobulin G
	left ventricular diastolic dysfunction
DC.description	Shiraki T., Kioka H., Ueda-Hayakawa I., et al. Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study. Journal of Dermatology 52(6), 1070-1077 (2025); https://doi.org/10.1111/1346-8138.17783.
DCTERMS.abstract	This cross-sectional pilot study investigated the clinical characteristics of anti-centromere antibody (ACA)–positive patients with below-the-knee arterial disease. Sixteen ACA-positive patients (mean age 69 ± 10 years; 94% women) underwent contrast-enhanced computed tomography evaluation, with arterial damage scored using the Global Limb Anatomic Staging System. Lower extremity arterial disease (LEAD) was defined as a below-the-knee arterial score ≥ 1 or > 50% stenosis in above-the-knee lesions. Eight patients were categorized into the LEAD group (below-the-knee arterial damage score 12 ± 6). The LEAD group showed significantly higher serum IgG1 levels (1029 ± 484 vs. 531 ± 72 mg/dL, p < 0.001) and a higher prevalence of diastolic dysfunction (62% vs. 0%, p = 0.026) compared to the non-LEAD group. Patients with diastolic dysfunction had significantly higher serum IgG1 levels than those without (1190 ± 559 vs. 593 ± 139 mg/dL, p = 0.008). These findings suggest associations between elevated serum IgG1 levels, below-the-knee arterial disease, and left ventricular diastolic dysfunction in ACA-positive patients.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102230
citation_title	Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study
citation_author	Shiraki, Tatsuya
	Kioka, Hidetaka
	Ueda-Hayakawa, Ikuko
	Takahara, Mitsuyoshi
	Tonomura, Kyoko
	Maekawa, Aya
	Kotobuki, Yorihisa
	Enchi, Yukihiro
	Ueda, Minako
	Takahari, Kosuke
	Takeda, Yasuharu
	Nakamura, Daisuke
	Mizote, Isamu
	Ohtani, Tomohito
	Fujimoto, Manabu
	Sakata, Yasushi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-05-16
citation_journal_title	Journal of Dermatology
citation_volume	52
citation_issue	6
citation_firstpage	1070
citation_lastpage	1077
citation_doi	https://doi.org/10.1111/1346-8138.17783
citation_public_url	https://hdl.handle.net/11094/102230

Elevated Serum Immunoglobulin G1 Levels and Left Ventricular Diastolic Dysfunction in Anti-Centromere Antibody–Positive Patients With Lower Extremity Arterial Disease: A Cross-Sectional Study

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