Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

Kawamura, Takuji; Saito, Shunsuke; Taguchi, Takura; Yoshioka, Daisuke; Kawamura, Ai; Misumi, Yusuke; Yamauchi, Takashi; Miyagawa, Shuji; Miyagawa, Shigeru

doi:https://doi.org/10.1007/s10047-025-01504-z

Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

Kawamura, Takuji; Saito, Shunsuke; Taguchi, Takura et al.

Journal of Artificial Organs, 2025

Number of Access:4（2025-07-22 20:43 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102244

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Title	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
Creator	NRID 1000060839398 1000060839398 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 CreatorName Kawamura, Takuji
	NRID 1000030600126 1000030600126 ORCID 0000-0002-0829-2891 0000-0002-0829-2891 researchmap permalink shunsaito shunsaito Scopus Author ID 57205524320 57205524320 CreatorName Saito, Shunsuke
	CreatorName Taguchi, Takura
	NRID 1000040645959 1000040645959 researchmap permalink d-yoshioka d-yoshioka Scopus Author ID 7003892845 7003892845 CreatorName Yoshioka, Daisuke
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 CreatorName Kawamura, Ai
	NRID 1000020631477 1000020631477 researchmap permalink yusukemisumi yusukemisumi CreatorName Misumi, Yusuke
	NRID 1000020527999 1000020527999 CreatorName Yamauchi, Takashi
	NRID 1000090273648 1000090273648 researchmap permalink read0185079 read0185079 CreatorName Miyagawa, Shuji
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 CreatorName Miyagawa, Shigeru
Subject	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Pig
Description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01504-z.
Abstract	Cardiac xenotransplantation utilizing genetically modified pigs presents a promising avenue for treating end-stage heart failure, a leading cause of mortality worldwide. This paper delineates the current landscape of heart failure treatment in Japan, emphasizing the limitations of existing therapies such as heart transplantation and implantable left ventricular assist devices. It discusses the history and advancements in the development of genetically modified pigs for xenotransplantation, highlighting recent breakthroughs and challenges. The manuscript also addresses the specific challenges facing the implementation of xenotransplantation in Japan, including the selection of suitable genetically modified pigs, ensuring organ safety, patient selection criteria, transplantation protocols, and immunosuppression strategies. Drawing from international experiences and ongoing research efforts, the paper emphasizes the potential of xenotransplantation while acknowledging the hurdles that must be overcome for widespread clinical adoption.
Publisher	Springer
Source Title	Journal of Artificial Organs
Date of Issued	2025-05-04
Language	English
Handle URL	https://hdl.handle.net/11094/102244
PISSN	14347229
eISSN	16190904
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s10047-025-01504-z
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Artificial Organs. 2025
DC.title	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
DC.creator	Kawamura, Takuji
	Saito, Shunsuke
	Taguchi, Takura
	Yoshioka, Daisuke
	Kawamura, Ai
	Misumi, Yusuke
	Yamauchi, Takashi
	Miyagawa, Shuji
	Miyagawa, Shigeru
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-05-04
DC.identifier	https://doi.org/10.1007/s10047-025-01504-z
DC.subject	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Pig
DC.description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01504-z.
DCTERMS.abstract	Cardiac xenotransplantation utilizing genetically modified pigs presents a promising avenue for treating end-stage heart failure, a leading cause of mortality worldwide. This paper delineates the current landscape of heart failure treatment in Japan, emphasizing the limitations of existing therapies such as heart transplantation and implantable left ventricular assist devices. It discusses the history and advancements in the development of genetically modified pigs for xenotransplantation, highlighting recent breakthroughs and challenges. The manuscript also addresses the specific challenges facing the implementation of xenotransplantation in Japan, including the selection of suitable genetically modified pigs, ensuring organ safety, patient selection criteria, transplantation protocols, and immunosuppression strategies. Drawing from international experiences and ongoing research efforts, the paper emphasizes the potential of xenotransplantation while acknowledging the hurdles that must be overcome for widespread clinical adoption.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102244
citation_title	Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation
citation_author	Kawamura, Takuji
	Saito, Shunsuke
	Taguchi, Takura
	Yoshioka, Daisuke
	Kawamura, Ai
	Misumi, Yusuke
	Yamauchi, Takashi
	Miyagawa, Shuji
	Miyagawa, Shigeru
citation_publisher	Springer
citation_language	English
citation_date	2025-05-04
citation_journal_title	Journal of Artificial Organs
citation_doi	https://doi.org/10.1007/s10047-025-01504-z
citation_public_url	https://hdl.handle.net/11094/102244

Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation

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