Spatial distribution of light-melanosome interaction dependent on irradiation fluence and spot size for short-pulsed laser skin treatment: A phantom study

Takeda, Gakuto; Shimojo, Yu; Ozawa, Toshiyuki et al.

Lasers in Medical Science, 2025, 40, 251

Number of Access:68（2025-11-18 19:47 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102250

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Title
Spatial distribution of light-melanosome interaction dependent on irradiation fluence and spot size for short-pulsed laser skin treatment: A phantom study
Creator
CreatorName
Takeda, Gakuto
NRID
1000030980734 1000030980734
ORCID
0000-0003-2102-1735 0000-0003-2102-1735
researchmap permalink
yu_shimojo yu_shimojo
CreatorName
Shimojo, Yu
NRID
1000050570602 1000050570602
CreatorName
Ozawa, Toshiyuki
NRID
1000010722829 1000010722829
researchmap permalink
t_nishim t_nishim
Scopus Author ID
36616463600 36616463600
CreatorName
Nishimura, Takahiro
Subject
Melanosome
Phantom
Pigmented lesion
Short-pulsed laser
Description
The version of record of this article, first published in Lasers in Medical Science, is available online at Publisher’s website: https://doi.org/10.1007/s10103-025-04430-x.
Abstract
Short-pulsed lasers provide safe and efficacious treatment of pigmented lesions by setting irradiation parameters based on immediate whitening resulting from vacuolization. However, visual observation of this phenomenon as an irradiation endpoint is subjective and makes it difficult to assess the depth to which the light response is induced inside the skin. To quantitatively understand the dependence of the light response on irradiation parameters, this study analyzes the spatial distribution of light-melanosome interaction based on the fluence distribution in an optical phantom. Nanosecond laser irradiation was applied to an optical phantom with a uniform distribution of melanosomes with varying irradiation fluence and spot size. The observed spatial distribution of the light-melanosome response was compared with the fluence distribution in the phantom calculated from numerical simulations. The resulting relationship between irradiation parameters and optical response showed that cavitation increased rapidly at an in-phantom fluence of 1.37 J/cm² and reached a saturated state at the threshold fluence for melanosome disruption. Additionally, increasing the spot size promoted cavitation at greater depths as well as increasing irradiation fluence, highlighting the need to consider both irradiation fluence and spot size for treatment depth control. The experimental results suggest the potential for quantitative control of optical responses in laser treatment of pigmented lesions. Further validation by experiments on samples with spatial distribution of cutaneous melanosomes is required.
Publisher
Springer Science and Business Media Deutschland GmbH
Source Title
Lasers in Medical Science
Volume (Issue)
40
Page
251
Date of Issued
2025-05-30
Language
English
Handle URL
https://hdl.handle.net/11094/102250
PISSN
02688921
eISSN
1435604X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s10103-025-04430-x
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article