In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects

Nishimura, Takahiro; Watanabe, Yusuke; Shimojo, Yu et al.

Lasers in Medical Science, 2025, 40(1), 273

Number of Access:8（2025-09-24 07:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102588

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Title
In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects
Creator
NRID
1000010722829 1000010722829
researchmap permalink
t_nishim t_nishim
Scopus Author ID
36616463600 36616463600
CreatorName
Nishimura, Takahiro
CreatorName
Watanabe, Yusuke
NRID
1000030980734 1000030980734
ORCID
0000-0003-2102-1735 0000-0003-2102-1735
researchmap permalink
yu_shimojo yu_shimojo
CreatorName
Shimojo, Yu
NRID
1000050570602 1000050570602
CreatorName
Ozawa, Toshiyuki
NRID
1000090382043 1000090382043
CreatorName
Tsuruta, Daisuke
Subject
Blue laser
Coagulation
In silico evaluation
Tissue vaporization
Description
The version of record of this article, first published in Lasers in Medical Science, is available online at Publisher’s website: https://doi.org/10.1007/s10103-025-04514-8.
Abstract
Blue diode laser irradiation has significant potential for realization of high vaporization efficiency with minimal thermal damage because of the strong blue light absorption of hemoglobin and the resulting shallow tissue penetration. This study presents an in silico framework for designing laser parameters, specifically pulse duration and power, for efficient vaporization under low-power irradiation conditions while minimizing thermal tissue damage. Computational simulations of laser-tissue interactions using the Monte Carlo light transport with dynamic optical properties model were conducted to evaluate vaporization and coagulation performance under various irradiation conditions. In addition to vaporization volume, the fraction of coagulated tissue was also calculated as a measure of thermal tissue damage. The in silico designs were validated experimentally through irradiation experiments performed on porcine liver tissue. Computational simulations revealed a non-monotonic relationship between pulse duration and vaporization volume at constant energy, as well as distinct trends for vaporization and coagulation. The experimental results confirmed the effectiveness of the simulation-derived parameters, and supported the practical utility of the proposed in silico design approach. The proposed in silico design approach enables quantitative analysis of vaporization and coagulation responses and can guide the development of safe and effective laser treatment protocols.
Publisher
Springer Science and Business Media Deutschland GmbH
Source Title
Lasers in Medical Science
Volume (Issue)
40(1)
Page
273
Date of Issued
2025-06-12
Language
English
Handle URL
https://hdl.handle.net/11094/102588
PISSN
02688921
eISSN
1435604X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s10103-025-04514-8
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article