Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation

Murakami, Takashi; Misumi, Yusuke; Yoshioka, Daisuke; Kawamura, Takuji; Kawamura, Ai; Yajima, Shin; Saito, Shunsuke; Yamauchi, Takashi; Miyagawa, Shigeru

doi:https://doi.org/10.1007/s10047-025-01516-9

Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation

Murakami, Takashi; Misumi, Yusuke; Yoshioka, Daisuke et al.

Journal of Artificial Organs, 2025

Number of Access:92（2025-10-22 00:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102595

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Title	Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation
Creator	CreatorName Murakami, Takashi
	NRID 1000020631477 1000020631477 researchmap permalink yusukemisumi yusukemisumi CreatorName Misumi, Yusuke
	NRID 1000040645959 1000040645959 researchmap permalink d-yoshioka d-yoshioka Scopus Author ID 7003892845 7003892845 CreatorName Yoshioka, Daisuke
	NRID 1000060839398 1000060839398 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 CreatorName Kawamura, Takuji
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 CreatorName Kawamura, Ai
	CreatorName Yajima, Shin
	NRID 1000030600126 1000030600126 ORCID 0000-0002-0829-2891 0000-0002-0829-2891 researchmap permalink shunsaito shunsaito Scopus Author ID 12768921000 12768921000 CreatorName Saito, Shunsuke
	NRID 1000020527999 1000020527999 researchmap permalink yamataka19720411 yamataka19720411 CreatorName Yamauchi, Takashi
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 CreatorName Miyagawa, Shigeru
Subject	Aortic insufficiency
Subject	Ventricular assisted device
Description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01516-9.
Abstract	Severe aortic insufficiency (AI) is a common complication associated with prolonged continuous-flow left ventricular assist device (CF-LVAD) therapy. This study aimed to investigate the clinical outcomes after surgical correction of de novo AI after LVAD implantation. A total of 190 patients underwent CF-LVAD implantation between January 2013 and June 2022. Of these, 24 had trivial or no AI before LVAD implantation and developed moderate or greater de novo AI after LVAD implantation. Patients who underwent aortic valve surgery before or concomitant with LVAD surgery were excluded. Among the 24 patients, surgeries were indicated for medically refractory de novo AI in 11 patients, who were included. The primary outcome was postoperative improvement in hemodynamics as assessed by right heart catheter examination, and the secondary endpoints were 3-year survival and freedom from death and/or heart failure readmission rates. The correction of de novo AI was accomplished with aortic valve closure using a bovine pericardial patch in 10 patients and prosthetic valve replacement in one patient. Significant differences (all p < 0.01) in pre- vs. post-surgery pulmonary artery wedge pressure, cardiac index, and mixed venous blood oxygen saturation were found. The mean follow-up period after LVAD implantation was 1413 days, and the 3-year survival rate was 90.9%. Three-year freedom from postoperative moderate or greater AI rate and freedom from heart failure readmission rate were both 90.9%. Postoperative hemodynamic status and survival outcomes are favorable in patients who underwent surgical aortic valve repair de novo AI after LVAD implantation.
Publisher	Springer
Source Title	Journal of Artificial Organs
Date of Issued	2025-06-28
Language	English
Handle URL	https://hdl.handle.net/11094/102595
PISSN	14347229
eISSN	16190904
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s10047-025-01516-9
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Artificial Organs. 2025
DC.title	Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation
DC.creator	Murakami, Takashi
	Misumi, Yusuke
	Yoshioka, Daisuke
	Kawamura, Takuji
	Kawamura, Ai
	Yajima, Shin
	Saito, Shunsuke
	Yamauchi, Takashi
	Miyagawa, Shigeru
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-28
DC.identifier	https://doi.org/10.1007/s10047-025-01516-9
DC.subject	Aortic insufficiency
DC.subject	Ventricular assisted device
DC.description	The version of record of this article, first published in Journal of Artificial Organs, is available online at Publisher’s website: https://doi.org/10.1007/s10047-025-01516-9.
DCTERMS.abstract	Severe aortic insufficiency (AI) is a common complication associated with prolonged continuous-flow left ventricular assist device (CF-LVAD) therapy. This study aimed to investigate the clinical outcomes after surgical correction of de novo AI after LVAD implantation. A total of 190 patients underwent CF-LVAD implantation between January 2013 and June 2022. Of these, 24 had trivial or no AI before LVAD implantation and developed moderate or greater de novo AI after LVAD implantation. Patients who underwent aortic valve surgery before or concomitant with LVAD surgery were excluded. Among the 24 patients, surgeries were indicated for medically refractory de novo AI in 11 patients, who were included. The primary outcome was postoperative improvement in hemodynamics as assessed by right heart catheter examination, and the secondary endpoints were 3-year survival and freedom from death and/or heart failure readmission rates. The correction of de novo AI was accomplished with aortic valve closure using a bovine pericardial patch in 10 patients and prosthetic valve replacement in one patient. Significant differences (all p < 0.01) in pre- vs. post-surgery pulmonary artery wedge pressure, cardiac index, and mixed venous blood oxygen saturation were found. The mean follow-up period after LVAD implantation was 1413 days, and the 3-year survival rate was 90.9%. Three-year freedom from postoperative moderate or greater AI rate and freedom from heart failure readmission rate were both 90.9%. Postoperative hemodynamic status and survival outcomes are favorable in patients who underwent surgical aortic valve repair de novo AI after LVAD implantation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102595
citation_title	Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation
citation_author	Murakami, Takashi
	Misumi, Yusuke
	Yoshioka, Daisuke
	Kawamura, Takuji
	Kawamura, Ai
	Yajima, Shin
	Saito, Shunsuke
	Yamauchi, Takashi
	Miyagawa, Shigeru
citation_publisher	Springer
citation_language	English
citation_date	2025-06-28
citation_journal_title	Journal of Artificial Organs
citation_doi	https://doi.org/10.1007/s10047-025-01516-9
citation_public_url	https://hdl.handle.net/11094/102595

Hemodynamic changes and mid-term results of surgical correction of de novo aortic valve insufficiency after left ventricular assist device implantation

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