Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation

Kugimiya, Rina; Hsu, Yu I.; Uyama, Hiroshi

Polymer Degradation and Stability, 2025, 241, 111514

Number of Access:39（2025-10-16 01:07 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102627

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Title
Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation
Creator
CreatorName
Kugimiya, Rina
NRID
1000010757678 1000010757678
ORCID
0000-0002-4533-7200 0000-0002-4533-7200
researchmap permalink
yuihsu yuihsu
Scopus Author ID
55389981500 55389981500
CreatorName
Hsu, Yu I.
NRID
1000070203594 1000070203594
ORCID
0000-0002-8587-2507 0000-0002-8587-2507
researchmap permalink
read0168389 read0168389
Scopus Author ID
7102108908 7102108908
CreatorName
Uyama, Hiroshi
Subject
Bioadhesion
Hydrogels
Poly(γ-glutamic acid)
SCHIFF-base reaction
Self-healing
Description
Kugimiya R., Hsu Y.I., Uyama H.. Self-healing Poly(γ-glutamic acid)/hyaluronic acid hydrogels with in situ Hydroxyapatite formation. Polymer Degradation and Stability 241, 111514 (2025); https://doi.org/10.1016/j.polymdegradstab.2025.111514.
Abstract
Biocompatible hydrogels have potential applications as scaffold materials for repairing bone defects. However, they lack strength suitable for bone tissue and are easily damaged. Therefore, the development of hydrogels with high mechanical strength and self-healing properties is strongly desired. Poly(γ-glutamic acid) (PGA), a polysaccharide derived from natto, and hyaluronic acid (HA), a major component of the extracellular matrix (ECM), are both biocompatible and biodegradable, and thus expected to be used as potential biopolymers. In this study, self-healing hydrogels using PGA modified with adipic acid dihydrazide (PADH) and oxidized HA (OHA) with in situ hydroxyapatite (HAp) formation were developed via the Schiff base reaction. The hydrogel was easily obtained at room temperature by blending the two polymer precursor solutions and was injectable using a syringe with a short gelation time. The resulting hydrogels showed a significant increase in the mechanical strength as the amount of HAp in the hydrogels increased. The hydrogels demonstrated self-healing properties through reversible acylhydrazone bonds, although the self-healing efficiency was reduced in hydrogels with a high HAp content. Moreover, the hydrogels exhibited a low swelling ratio, 3D porous structures, and adhesion to chicken bone, suggesting that they are suitable for treating bone defects. In summary, our results indicate the potential of PGA/HA/HAp hydrogels given their injectability, superior mechanical strength relative to typical hydrogels, self-healing properties, and adhesion to bone.
Publisher
Elsevier Ltd
Source Title
Polymer Degradation and Stability
Volume (Issue)
241
Page
111514
Date of Issued
2025-07-08
Language
English
Handle URL
https://hdl.handle.net/11094/102627
PISSN
01413910
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.polymdegradstab.2025.111514
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article