Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

Kida, Hirota; Matsuoka, Yuki; Sakamoto, Daisuke; Hikoso, Shungo; Nakatani, Daisaku; Okada, Katsuki; Sunaga, Akihiro; Sato, Taiki; Kitamura, Tetsuhisa; Sakata, Yasuhiko; Sato, Hiroshi; Hori, Masatsugu; Komuro, Issei; Sotomi, Yohei; Sakata, Yasushi

doi:https://doi.org/10.1161/JAHA.125.043005

Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

Kida, Hirota; Matsuoka, Yuki; Sakamoto, Daisuke et al.

Journal of the American Heart Association, 2025, 14(14), e043005

Number of Access:259（2025-12-11 21:31 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102637

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Title	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
Creator	CreatorName Kida, Hirota
	CreatorName Matsuoka, Yuki
	CreatorName Sakamoto, Daisuke
	NRID 1000030423164 1000030423164 ORCID 0000-0003-2284-1970 0000-0003-2284-1970 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 57578643800 57578643800 CreatorName Hikoso, Shungo
	NRID 1000060444535 1000060444535 ORCID 0000-0002-1534-2033 0000-0002-1534-2033 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000020776489 1000020776489 ORCID 0000-0002-1725-781X 0000-0002-1725-781X researchmap permalink katsuki_okada katsuki_okada Scopus Author ID 13613369100 13613369100 CreatorName Okada, Katsuki
	NRID 1000010812258 1000010812258 ORCID 0000-0003-2590-6696 0000-0003-2590-6696 researchmap permalink 10812258 10812258 Scopus Author ID 56647970400 56647970400 CreatorName Sunaga, Akihiro
	CreatorName Sato, Taiki
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000090379206 1000090379206 ORCID 0000-0001-6809-8487 0000-0001-6809-8487 researchmap permalink yasuhiko.sakata.2020 yasuhiko.sakata.2020 Scopus Author ID 7201629964 7201629964 CreatorName Sakata, Yasuhiko
	CreatorName Sato, Hiroshi
	NRID 1000020124779 1000020124779 CreatorName Hori, Masatsugu
	CreatorName Komuro, Issei
	CreatorName Sotomi, Yohei
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	acute myocardial infarction
	chronic kidney disease
	hemodialysis
	primary percutaneous coronary intervention
	real‐world data
Description	Kida H., Matsuoka Y., Sakamoto D., et al. Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction. Journal of the American Heart Association 14, e043005 (2025); https://doi.org/10.1161/JAHA.125.043005.
Abstract	BACKGROUND: Primary percutaneous coronary intervention is the preferred treatment for acute myocardial infarction. However, in patients with chronic kidney disease (CKD), the use of contrast media can exacerbate renal dysfunction, often necessitating alternative strategies. The impact of CKD on acute myocardial infarction prognosis, particularly in the context of percutaneous coronary intervention, is not fully understood. METHODS AND RESULTS: This study utilized real-world registry data from the OACIS (Osaka Acute Coronary Insufficiency Study) to evaluate prognosis across different CKD grades, including advanced CKD and hemodialysis. From a database of 12 093 patients with acute myocardial infarction, we identified 8411 patients with renal function data at admission (a median follow-up period of 1765 days). These patients were classified into 8 CKD categories based on estimated glomerular filtration rate (eGFR); G1 (eGFR≥90 mL/min per 1.73 m²): n=1122, G2 (90>eGFR ≥60 mL/min per 1.73 m²): n=3588, G3a (60>eGFR≥45 mL/min per 1.73 m²): n=1923, G3b (45>eGFR≥30 mL/min per 1.73 m²): n=1030, G4: (30>eGFR≥15 mL/min per 1.73 m²): n=473, G5a: (15>eGFR≥8 mL/min per 1.73 m²): n=80, G5b: (eGFR<8 mL/min per 1.73 m²): n=53 and hemodialysis: n=142. Percutaneous coronary intervention rates declined with advancing CKD, reaching the lowest in G5a (80.3%) but increasing again in G5b and hemodialysis groups (≈90%). Thirty-day all-cause mortality rates increased with CKD severity, with a notable reduction in G5b (9.4%) before rising again in patients with hemodialysis (16.9%). Long-term data showed a progressive worsening of prognosis with advanced CKD, culminating in the poorest outcomes among patients with hemodialysis. CONCLUSIONS: This study demonstrated differential impacts of CKD severity on short- and long-term clinical outcomes in the context of patients with acute myocardial infarction.
Publisher	American Heart Association, Inc.
Source Title	Journal of the American Heart Association
Volume (Issue)	14(14)
Page	e043005
Date of Issued	2025-07-15
Language	English
Handle URL	https://hdl.handle.net/11094/102637
eISSN	20479980
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1161/JAHA.125.043005
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of the American Heart Association. 2025, 14(14), p. e043005
DC.title	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
DC.creator	Kida, Hirota
	Matsuoka, Yuki
	Sakamoto, Daisuke
	Hikoso, Shungo
	Nakatani, Daisaku
	Okada, Katsuki
	Sunaga, Akihiro
	Sato, Taiki
	Kitamura, Tetsuhisa
	Sakata, Yasuhiko
	Sato, Hiroshi
	Hori, Masatsugu
	Komuro, Issei
	Sotomi, Yohei
	Sakata, Yasushi
DC.publisher	American Heart Association, Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-15
DC.identifier	https://doi.org/10.1161/JAHA.125.043005
DC.subject	acute myocardial infarction
	chronic kidney disease
	hemodialysis
	primary percutaneous coronary intervention
	real‐world data
DC.description	Kida H., Matsuoka Y., Sakamoto D., et al. Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction. Journal of the American Heart Association 14, e043005 (2025); https://doi.org/10.1161/JAHA.125.043005.
DCTERMS.abstract	BACKGROUND: Primary percutaneous coronary intervention is the preferred treatment for acute myocardial infarction. However, in patients with chronic kidney disease (CKD), the use of contrast media can exacerbate renal dysfunction, often necessitating alternative strategies. The impact of CKD on acute myocardial infarction prognosis, particularly in the context of percutaneous coronary intervention, is not fully understood. METHODS AND RESULTS: This study utilized real-world registry data from the OACIS (Osaka Acute Coronary Insufficiency Study) to evaluate prognosis across different CKD grades, including advanced CKD and hemodialysis. From a database of 12 093 patients with acute myocardial infarction, we identified 8411 patients with renal function data at admission (a median follow-up period of 1765 days). These patients were classified into 8 CKD categories based on estimated glomerular filtration rate (eGFR); G1 (eGFR≥90 mL/min per 1.73 m²): n=1122, G2 (90>eGFR ≥60 mL/min per 1.73 m²): n=3588, G3a (60>eGFR≥45 mL/min per 1.73 m²): n=1923, G3b (45>eGFR≥30 mL/min per 1.73 m²): n=1030, G4: (30>eGFR≥15 mL/min per 1.73 m²): n=473, G5a: (15>eGFR≥8 mL/min per 1.73 m²): n=80, G5b: (eGFR<8 mL/min per 1.73 m²): n=53 and hemodialysis: n=142. Percutaneous coronary intervention rates declined with advancing CKD, reaching the lowest in G5a (80.3%) but increasing again in G5b and hemodialysis groups (≈90%). Thirty-day all-cause mortality rates increased with CKD severity, with a notable reduction in G5b (9.4%) before rising again in patients with hemodialysis (16.9%). Long-term data showed a progressive worsening of prognosis with advanced CKD, culminating in the poorest outcomes among patients with hemodialysis. CONCLUSIONS: This study demonstrated differential impacts of CKD severity on short- and long-term clinical outcomes in the context of patients with acute myocardial infarction.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102637
citation_title	Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction
citation_author	Kida, Hirota
	Matsuoka, Yuki
	Sakamoto, Daisuke
	Hikoso, Shungo
	Nakatani, Daisaku
	Okada, Katsuki
	Sunaga, Akihiro
	Sato, Taiki
	Kitamura, Tetsuhisa
	Sakata, Yasuhiko
	Sato, Hiroshi
	Hori, Masatsugu
	Komuro, Issei
	Sotomi, Yohei
	Sakata, Yasushi
citation_publisher	American Heart Association, Inc.
citation_language	English
citation_date	2025-07-15
citation_journal_title	Journal of the American Heart Association
citation_volume	14
citation_issue	14
citation_firstpage	e043005
citation_doi	https://doi.org/10.1161/JAHA.125.043005
citation_public_url	https://hdl.handle.net/11094/102637

Renal Function and its Time-Sensitive Influence on Survival Rates of Acute Myocardial Infarction

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