The Proposed Categorization of Vitiligo Lesions on the Hands

Yokoi, Kazunori; Ishitsuka, Yosuke; Kusao, Kanae; Wang, Jing; Kawashima, Haruna; Jikihara, Narumi; Nakagawa, Seitaro; Kiyohara, Eiji; Arase, Noriko; Fujimoto, Manabu; Tanemura, Atsushi

doi:https://doi.org/10.1111/pcmr.70039

The Proposed Categorization of Vitiligo Lesions on the Hands

Yokoi, Kazunori; Ishitsuka, Yosuke; Kusao, Kanae et al.

Pigment Cell and Melanoma Research, 2025, 38(4), e70039

Number of Access:42（2025-11-26 01:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102748

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Title	The Proposed Categorization of Vitiligo Lesions on the Hands
Creator	ORCID 0000-0003-0582-7325 0000-0003-0582-7325 Scopus Author ID 57209538113 57209538113 CreatorName Yokoi, Kazunori
	NRID 1000050778628 1000050778628 ORCID 0000-0002-1733-5427 0000-0002-1733-5427 researchmap permalink ishitsuka ishitsuka Scopus Author ID 6602426038 6602426038 CreatorName Ishitsuka, Yosuke
	CreatorName Kusao, Kanae
	CreatorName Wang, Jing
	CreatorName Kawashima, Haruna
	CreatorName Jikihara, Narumi
	NRID 1000090717836 1000090717836 ORCID 0000-0002-1119-0001 0000-0002-1119-0001 researchmap permalink starotaro starotaro Scopus Author ID 57193422140 57193422140 CreatorName Nakagawa, Seitaro
	NRID 1000070423176 1000070423176 ORCID 0000-0002-0436-4296 0000-0002-0436-4296 researchmap permalink derma120 derma120 Scopus Author ID 56384380500 56384380500 CreatorName Kiyohara, Eiji
	NRID 1000030360481 1000030360481 ORCID 0000-0003-3966-3437 0000-0003-3966-3437 researchmap permalink norikoa norikoa Scopus Author ID 6701920120 6701920120 CreatorName Arase, Noriko
	NRID 1000090272591 1000090272591 ORCID 0000-0002-3062-4872 0000-0002-3062-4872 researchmap permalink read0122743 read0122743 Scopus Author ID 7401866712 7401866712 CreatorName Fujimoto, Manabu
	NRID 1000050457016 1000050457016 researchmap permalink tane1225 tane1225 Scopus Author ID 6508011282 6508011282 CreatorName Tanemura, Atsushi
Subject	classification
	clustering
	distribution
	hands
	vitiligo
Description	Yokoi K., Ishitsuka Y., Kusao K., et al. The Proposed Categorization of Vitiligo Lesions on the Hands. Pigment Cell and Melanoma Research 38, e70039 (2025); https://doi.org/10.1111/pcmr.70039.
Abstract	Vitiligo is a common depigmentation disorder characterized by patchy white macules. It has been reported that vitiligo lesions, particularly in exposed areas, such as the face and hands, cause severe psychological distress. Although the classification and outcome of facial vitiligo have been proposed, clinical analyses featuring hand vitiligo are very limited, irrespective of its severe psychological impact. In this study, we investigated hand lesions in nonsegmental vitiligo patients and found that the distribution of hand vitiligo was symmetric, whereas the dominant hand was more frequently affected. Moreover, our clustering analysis newly classified hand vitiligo lesions into four distinct subtypes (n = 140): focal/scattered (46.4%), distal digit (31.4%), universal (12.9%), and proximal digit (9.2%) and their clinical characteristics. The focal/scattered type is the most common subtype and exhibits a distinctive prevalence in pediatric cases. The distal digit type was suggested to be associated with smoking or the Koebner phenomenon. The universal type is a distinct subtype, with onset in older age and a poor response to treatment. The proximal digit type is the rarest subtype, with onset at a young age. In conclusion, these findings deepen our understanding of the heterogeneity of hand vitiligo and support the development of personalized treatment strategies.
Publisher	John Wiley and Sons Inc
Source Title	Pigment Cell and Melanoma Research
Volume (Issue)	38(4)
Page	e70039
Date of Issued	2025-07-10
Language	English
Handle URL	https://hdl.handle.net/11094/102748
PISSN	17551471
eISSN	1755148X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/pcmr.70039
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Pigment Cell and Melanoma Research. 2025, 38(4), p. e70039
DC.title	The Proposed Categorization of Vitiligo Lesions on the Hands
DC.creator	Yokoi, Kazunori
	Ishitsuka, Yosuke
	Kusao, Kanae
	Wang, Jing
	Kawashima, Haruna
	Jikihara, Narumi
	Nakagawa, Seitaro
	Kiyohara, Eiji
	Arase, Noriko
	Fujimoto, Manabu
	Tanemura, Atsushi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-10
DC.identifier	https://doi.org/10.1111/pcmr.70039
DC.subject	classification
	clustering
	distribution
	hands
	vitiligo
DC.description	Yokoi K., Ishitsuka Y., Kusao K., et al. The Proposed Categorization of Vitiligo Lesions on the Hands. Pigment Cell and Melanoma Research 38, e70039 (2025); https://doi.org/10.1111/pcmr.70039.
DCTERMS.abstract	Vitiligo is a common depigmentation disorder characterized by patchy white macules. It has been reported that vitiligo lesions, particularly in exposed areas, such as the face and hands, cause severe psychological distress. Although the classification and outcome of facial vitiligo have been proposed, clinical analyses featuring hand vitiligo are very limited, irrespective of its severe psychological impact. In this study, we investigated hand lesions in nonsegmental vitiligo patients and found that the distribution of hand vitiligo was symmetric, whereas the dominant hand was more frequently affected. Moreover, our clustering analysis newly classified hand vitiligo lesions into four distinct subtypes (n = 140): focal/scattered (46.4%), distal digit (31.4%), universal (12.9%), and proximal digit (9.2%) and their clinical characteristics. The focal/scattered type is the most common subtype and exhibits a distinctive prevalence in pediatric cases. The distal digit type was suggested to be associated with smoking or the Koebner phenomenon. The universal type is a distinct subtype, with onset in older age and a poor response to treatment. The proximal digit type is the rarest subtype, with onset at a young age. In conclusion, these findings deepen our understanding of the heterogeneity of hand vitiligo and support the development of personalized treatment strategies.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	102748
citation_title	The Proposed Categorization of Vitiligo Lesions on the Hands
citation_author	Yokoi, Kazunori
	Ishitsuka, Yosuke
	Kusao, Kanae
	Wang, Jing
	Kawashima, Haruna
	Jikihara, Narumi
	Nakagawa, Seitaro
	Kiyohara, Eiji
	Arase, Noriko
	Fujimoto, Manabu
	Tanemura, Atsushi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-07-10
citation_journal_title	Pigment Cell and Melanoma Research
citation_volume	38
citation_issue	4
citation_firstpage	e70039
citation_doi	https://doi.org/10.1111/pcmr.70039
citation_public_url	https://hdl.handle.net/11094/102748

The Proposed Categorization of Vitiligo Lesions on the Hands

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