Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study

Kakeda, Kyosuke; Kanemoto, Hideki; Yoshiyama, Kenji; Suehiro, Takashi; Umeda, Sumiyo; Nakatani, Yoshitaka; Koizumi, Fuyuki; Satake, Yuto; Yamakawa, Maki; Yamamoto, Yuki; Isohashi, Kayako; Kato, Hiroki; Tomiyama, Noriyuki; Hashimoto, Mamoru; Ikeda, Manabu

doi:https://doi.org/10.1111/psyg.70082

Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study

Kakeda, Kyosuke; Kanemoto, Hideki; Yoshiyama, Kenji et al.

Psychogeriatrics, 2025, 25(5), e70082

Number of Access:68（2025-11-02 07:21 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102762

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Title	Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study
Creator	CreatorName Kakeda, Kyosuke
	NRID 1000020838932 1000020838932 ORCID 0000-0003-3662-1469 0000-0003-3662-1469 researchmap permalink hkane_gerpsy hkane_gerpsy Scopus Author ID 56521238700 56521238700 CreatorName Kanemoto, Hideki
	NRID 1000020426498 1000020426498 ORCID 0009-0008-4353-8632 0009-0008-4353-8632 researchmap permalink kenyoshiyama kenyoshiyama Scopus Author ID 55758733500 55758733500 CreatorName Yoshiyama, Kenji
	NRID 1000030866611 1000030866611 researchmap permalink suehiro-takashi suehiro-takashi Scopus Author ID 57190874433 57190874433 CreatorName Suehiro, Takashi
	CreatorName Umeda, Sumiyo
	CreatorName Nakatani, Yoshitaka
	ORCID 0000-0002-4371-9256 0000-0002-4371-9256 researchmap permalink fuyukikoizumi fuyukikoizumi Scopus Author ID 57328518600 57328518600 CreatorName Koizumi, Fuyuki
	ORCID 0000-0002-9350-3162 0000-0002-9350-3162 researchmap permalink y.satake y.satake Scopus Author ID 57218214023 57218214023 CreatorName Satake, Yuto
	CreatorName Yamakawa, Maki
	CreatorName Yamamoto, Yuki
	NRID 1000050598604 1000050598604 ORCID 0000-0002-2081-3020 0000-0002-2081-3020 researchmap permalink researchmap5849 researchmap5849 CreatorName Isohashi, Kayako
	NRID 1000020448054 1000020448054 ORCID 0000-0003-0838-6772 0000-0003-0838-6772 researchmap permalink kato-h kato-h Scopus Author ID 55585587900 55585587900 CreatorName Kato, Hiroki
	NRID 1000050294070 1000050294070 ORCID 0000-0001-9918-7327 0000-0001-9918-7327 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
	NRID 1000020452881 1000020452881 CreatorName Hashimoto, Mamoru
	NRID 1000060284395 1000060284395 researchmap permalink manabu_ikeda manabu_ikeda Scopus Author ID 7404692889 7404692889 CreatorName Ikeda, Manabu
Subject	cerebral blood flow
	Lewy body dementia
	magnetic resonance imaging
	postcentral gyrus
	tactile hallucinations
Description	Kakeda K., Kanemoto H., Yoshiyama K., et al. Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study. Psychogeriatrics 25, e70082 (2025); https://doi.org/10.1111/psyg.70082.
Abstract	Background: We examined the clinical features of tactile hallucinations associated with dementia with Lewy bodies and investigated their neural substrates. Methods: This retrospective observational cross-sectional study enrolled 147 patients with probable dementia with Lewy bodies from the Department of Psychiatry, The University of Osaka Hospital, and collected the data of Clinical Dementia Rating, Mini-Mental State Examination, Neuropsychiatric Inventory-plus, and their demographics. Furthermore, magnetic resonance imaging and cerebral blood flow data from single-photon emission computed tomography were collected when possible. Results: Ten patients (6.9%) had tactile hallucinations. There were no significant differences in age, sex, or cognitive function between the patients with and without tactile hallucinations. The patients with tactile hallucinations had more severe neuropsychiatric symptoms, although none developed delusional infestations. Magnetic resonance imaging showed lower grey matter volume in the right postcentral gyrus, and single-photon emission computed tomography images showed lower cerebral blood flow in the left postcentral gyrus and relatively higher cerebral blood flow in the left inferior frontal gyrus in patients with tactile hallucinations than in those without. Single-photon emission computed tomography was available for only three patients among those with tactile hallucinations. Cerebral blood flow in the postcentral gyrus was reduced in all three patients compared with the database of age-sex-matched healthy controls. Conclusions: These findings suggest that tactile hallucinations in patients with dementia with Lewy bodies may be related to damage in the postcentral gyrus and preserved function in the frontal lobe; this could be consistent with the “release phenomena” hypothesis of hallucinations.
Publisher	John Wiley and Sons Inc
Source Title	Psychogeriatrics
Volume (Issue)	25(5)
Page	e70082
Date of Issued	2025-08-12
Language	English
Handle URL	https://hdl.handle.net/11094/102762
PISSN	13463500
eISSN	14798301
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/psyg.70082
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Psychogeriatrics. 2025, 25(5), p. e70082
DC.title	Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study
DC.creator	Kakeda, Kyosuke
	Kanemoto, Hideki
	Yoshiyama, Kenji
	Suehiro, Takashi
	Umeda, Sumiyo
	Nakatani, Yoshitaka
	Koizumi, Fuyuki
	Satake, Yuto
	Yamakawa, Maki
	Yamamoto, Yuki
	Isohashi, Kayako
	Kato, Hiroki
	Tomiyama, Noriyuki
	Hashimoto, Mamoru
	Ikeda, Manabu
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-08-12
DC.identifier	https://doi.org/10.1111/psyg.70082
DC.subject	cerebral blood flow
	Lewy body dementia
	magnetic resonance imaging
	postcentral gyrus
	tactile hallucinations
DC.description	Kakeda K., Kanemoto H., Yoshiyama K., et al. Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study. Psychogeriatrics 25, e70082 (2025); https://doi.org/10.1111/psyg.70082.
DCTERMS.abstract	Background: We examined the clinical features of tactile hallucinations associated with dementia with Lewy bodies and investigated their neural substrates. Methods: This retrospective observational cross-sectional study enrolled 147 patients with probable dementia with Lewy bodies from the Department of Psychiatry, The University of Osaka Hospital, and collected the data of Clinical Dementia Rating, Mini-Mental State Examination, Neuropsychiatric Inventory-plus, and their demographics. Furthermore, magnetic resonance imaging and cerebral blood flow data from single-photon emission computed tomography were collected when possible. Results: Ten patients (6.9%) had tactile hallucinations. There were no significant differences in age, sex, or cognitive function between the patients with and without tactile hallucinations. The patients with tactile hallucinations had more severe neuropsychiatric symptoms, although none developed delusional infestations. Magnetic resonance imaging showed lower grey matter volume in the right postcentral gyrus, and single-photon emission computed tomography images showed lower cerebral blood flow in the left postcentral gyrus and relatively higher cerebral blood flow in the left inferior frontal gyrus in patients with tactile hallucinations than in those without. Single-photon emission computed tomography was available for only three patients among those with tactile hallucinations. Cerebral blood flow in the postcentral gyrus was reduced in all three patients compared with the database of age-sex-matched healthy controls. Conclusions: These findings suggest that tactile hallucinations in patients with dementia with Lewy bodies may be related to damage in the postcentral gyrus and preserved function in the frontal lobe; this could be consistent with the “release phenomena” hypothesis of hallucinations.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102762
citation_title	Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study
citation_author	Kakeda, Kyosuke
	Kanemoto, Hideki
	Yoshiyama, Kenji
	Suehiro, Takashi
	Umeda, Sumiyo
	Nakatani, Yoshitaka
	Koizumi, Fuyuki
	Satake, Yuto
	Yamakawa, Maki
	Yamamoto, Yuki
	Isohashi, Kayako
	Kato, Hiroki
	Tomiyama, Noriyuki
	Hashimoto, Mamoru
	Ikeda, Manabu
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-08-12
citation_journal_title	Psychogeriatrics
citation_volume	25
citation_issue	5
citation_firstpage	e70082
citation_doi	https://doi.org/10.1111/psyg.70082
citation_public_url	https://hdl.handle.net/11094/102762

Clinical and Neuroimaging Features of Tactile Hallucinations in Patients With Dementia With Lewy Bodies: A Cross-Sectional Study

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