Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice

Kondo, Yuta; Fukuda, Shiro; Kawada, Keitaro; Kita, Shunbun; Nakamura, Yuto; Nagao, Hirofumi; Obata, Yoshinari; Fujishima, Yuya; Maeda, Norikazu; Nishizawa, Hitoshi; Shimomura, Iichiro

doi:https://doi.org/10.1016/j.bbrc.2025.152459

Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice

Kondo, Yuta; Fukuda, Shiro; Kawada, Keitaro et al.

Biochemical and Biophysical Research Communications, 2025, 779, 152459

Number of Access:32（2025-10-23 10:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102785

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Title	Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice
Creator	CreatorName Kondo, Yuta
	NRID 1000000896467 1000000896467 researchmap permalink sfukuda-ou sfukuda-ou Scopus Author ID 55766129200 55766129200 CreatorName Fukuda, Shiro
	CreatorName Kawada, Keitaro
	NRID 1000010746572 1000010746572 ORCID 0000-0002-8937-0053 0000-0002-8937-0053 researchmap permalink Shunbun_Kita Shunbun_Kita Scopus Author ID 36873116500 36873116500 CreatorName Kita, Shunbun
	CreatorName Nakamura, Yuto
	NRID 1000070983146 1000070983146 ORCID 0009-0001-1261-4160 0009-0001-1261-4160 researchmap permalink Hirofumi_Nagao Hirofumi_Nagao CreatorName Nagao, Hirofumi
	ORCID 0000-0002-3443-3635 0000-0002-3443-3635 researchmap permalink osaka-u-obata osaka-u-obata CreatorName Obata, Yoshinari
	NRID 1000010779789 1000010779789 researchmap permalink Yuya_Fujishima Yuya_Fujishima Scopus Author ID 54410318600 54410318600 CreatorName Fujishima, Yuya
	NRID 1000030506308 1000030506308 CreatorName Maeda, Norikazu
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 CreatorName Shimomura, Iichiro
Description	Kondo Y., Fukuda S., Kawada K., et al. Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice. Biochemical and Biophysical Research Communications 779, 152459 (2025); https://doi.org/10.1016/j.bbrc.2025.152459.
Abstract	Aim & objective: We have reported that T-cadherin (T-cad), a glycosylphosphatidylinositol-anchored protein that specifically binds to adiponectin, exists in the human serum as a soluble form (sT-cad). sT-cad promotes pancreatic β-cell proliferations, indicating a potential organ-protective role. This study aimed to the cardioprotective effect of sT-cad. Methods & results: The sT-cad-expressing plasmid was administered to 7-week-old wild-type mice. One week after administration, transverse aortic constriction (TAC) surgery was performed to induce pressure-overload heart failure. Then, the mice were sacrificed at 2 weeks after the surgery. In the mice that received sT-cad, the TAC-induced increase in heart weight and decline in cardiac function were significantly attenuated. Based on the cardiac histological analysis, sT-cad suppressed both cardiomyocyte hypertrophy and cardiac fibrosis. Cardiac RNA sequencing analysis showed that sT-cad inhibited the TAC-induced upregulation of fibrosis-related genes. In addition, in NIH-3T3 fibroblasts, sT-cad supplementation suppressed the TGF-β-induced mRNA expression of Acta2, a myofibroblast marker. Conclusion: sT-cad ameliorated the pressure overload-induced heart failure in mice.
Publisher	Elsevier Inc.
Source Title	Biochemical and Biophysical Research Communications
Volume (Issue)	779
Page	152459
Date of Issued	2025-09-12
Language	English
Handle URL	https://hdl.handle.net/11094/102785
PISSN	0006291X
eISSN	10902104
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bbrc.2025.152459
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
CopyRight	© 2025 The Authors
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Biochemical and Biophysical Research Communications. 2025, 779, p. 152459
DC.title	Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice
DC.creator	Kondo, Yuta
	Fukuda, Shiro
	Kawada, Keitaro
	Kita, Shunbun
	Nakamura, Yuto
	Nagao, Hirofumi
	Obata, Yoshinari
	Fujishima, Yuya
	Maeda, Norikazu
	Nishizawa, Hitoshi
	Shimomura, Iichiro
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-12
DC.identifier	https://doi.org/10.1016/j.bbrc.2025.152459
DC.description	Kondo Y., Fukuda S., Kawada K., et al. Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice. Biochemical and Biophysical Research Communications 779, 152459 (2025); https://doi.org/10.1016/j.bbrc.2025.152459.
DCTERMS.abstract	Aim & objective: We have reported that T-cadherin (T-cad), a glycosylphosphatidylinositol-anchored protein that specifically binds to adiponectin, exists in the human serum as a soluble form (sT-cad). sT-cad promotes pancreatic β-cell proliferations, indicating a potential organ-protective role. This study aimed to the cardioprotective effect of sT-cad. Methods & results: The sT-cad-expressing plasmid was administered to 7-week-old wild-type mice. One week after administration, transverse aortic constriction (TAC) surgery was performed to induce pressure-overload heart failure. Then, the mice were sacrificed at 2 weeks after the surgery. In the mice that received sT-cad, the TAC-induced increase in heart weight and decline in cardiac function were significantly attenuated. Based on the cardiac histological analysis, sT-cad suppressed both cardiomyocyte hypertrophy and cardiac fibrosis. Cardiac RNA sequencing analysis showed that sT-cad inhibited the TAC-induced upregulation of fibrosis-related genes. In addition, in NIH-3T3 fibroblasts, sT-cad supplementation suppressed the TGF-β-induced mRNA expression of Acta2, a myofibroblast marker. Conclusion: sT-cad ameliorated the pressure overload-induced heart failure in mice.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.rights	© 2025 The Authors
DC.format	102785
citation_title	Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice
citation_author	Kondo, Yuta
	Fukuda, Shiro
	Kawada, Keitaro
	Kita, Shunbun
	Nakamura, Yuto
	Nagao, Hirofumi
	Obata, Yoshinari
	Fujishima, Yuya
	Maeda, Norikazu
	Nishizawa, Hitoshi
	Shimomura, Iichiro
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2025-09-12
citation_journal_title	Biochemical and Biophysical Research Communications
citation_volume	779
citation_firstpage	152459
citation_doi	https://doi.org/10.1016/j.bbrc.2025.152459
citation_public_url	https://hdl.handle.net/11094/102785

Soluble T-cadherin ameliorates pressure overload-induced heart failure and cardiac fibrosis in mice

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