Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)

Koretsune, Yuji; Sone, Miyuki; Kimura, Shintaro; Sugawara, Shunsuke; Kodama, Yoshihisa; Kimura, Yasushi; Tanaka, Kaishu; Ono, Yusuke; Higashihara, Hiroki; Arai, Yasuaki; Kusumoto, Masahiko; Tomiyama, Noriyuki

doi:https://doi.org/10.1016/j.jvir.2025.05.033

Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)

Koretsune, Yuji; Sone, Miyuki; Kimura, Shintaro et al.

Journal of Vascular and Interventional Radiology, 2025

Number of Access:7（2025-11-02 07:21 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102858

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Title	Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)
Creator	NRID 1000020973522 1000020973522 ORCID 0000-0002-0566-4856 0000-0002-0566-4856 Scopus Author ID 57223435466 57223435466 CreatorName Koretsune, Yuji
	NRID 1000000226713 1000000226713 CreatorName Sone, Miyuki
	CreatorName Kimura, Shintaro
	CreatorName Sugawara, Shunsuke
	CreatorName Kodama, Yoshihisa
	NRID 1000080774223 1000080774223 ORCID 0000-0003-3759-1580 0000-0003-3759-1580 researchmap permalink kimurayasushi kimurayasushi Scopus Author ID 57209796915 57209796915 CreatorName Kimura, Yasushi
	NRID 1000050839701 1000050839701 ORCID 0000-0001-5652-1532 0000-0001-5652-1532 researchmap permalink ushuika- ushuika- Scopus Author ID 55311437600 55311437600 CreatorName Tanaka, Kaishu
	NRID 1000090816901 1000090816901 researchmap permalink y-ono y-ono Scopus Author ID 56406831000 56406831000 CreatorName Ono, Yusuke
	NRID 1000090423186 1000090423186 ORCID 0000-0003-2110-0222 0000-0003-2110-0222 researchmap permalink hiroki-portal hiroki-portal Scopus Author ID 13605077500 13605077500 CreatorName Higashihara, Hiroki
	NRID 1000040184262 1000040184262 CreatorName Arai, Yasuaki
	NRID 1000090252767 1000090252767 CreatorName Kusumoto, Masahiko
	NRID 1000050294070 1000050294070 ORCID 0000-0001-9918-7327 0000-0001-9918-7327 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
Description	Koretsune Y., Sone M., Kimura S., et al. Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study). Journal of Vascular and Interventional Radiology , (2025); https://doi.org/10.1016/j.jvir.2025.05.033.
Abstract	Purpose: To investigate the incidence and risk factors of silent brain infarction following transradial hepatic interventional procedures. Materials and Methods: In this multicenter prospective observational study, 57 patients scheduled for transradial hepatic intervention underwent preprocedural and postprocedural magnetic resonance (MR) imaging. The study was divided into 2 periods: August–December 2022 (former group) and June–December 2023 (latter group). In the latter period, selection criteria were modified to include only patients with a left subclavian artery (SCA) angle of >50°, and the protocol was revised to incorporate strict heparinization and continuous catheter flushing. The primary end point was the incidence of silent brain infarction, and associated risk factors were analyzed. Results: Among 57 registered patients, 55 underwent transradial access (TRA). Silent brain infarction was detected in 9 patients (16.4%), with no symptomatic cerebral infarction. The incidence reduced significantly in the latter compared with that in the former group (2.9% vs 40%; P < 0.001). Univariate analysis in the former group demonstrated prolonged catheterization time from the left SCA to descending thoracic aorta as a significant risk factor (575.0 seconds [SD ± 536.2] vs 57.9 seconds [SD ± 59.4]; P = .008), with a cutoff value of 58 seconds (sensitivity, 0.727; specificity, 0.875). Moreover, patients with a left SCA angle of ≤50° demonstrated a significantly higher incidence of silent brain infarction (P = .049). Conclusions: This study demonstrated that transradial hepatic intervention was associated with a 40% incidence of silent brain infarction, which may be reduced by protocols limiting TRA to patients with favorable anatomy and incorporating continuous heparinization and catheter perfusion.
Publisher	Elsevier Inc.
Source Title	Journal of Vascular and Interventional Radiology
Date of Issued	2025-10-22
Language	English
Handle URL	https://hdl.handle.net/11094/102858
PISSN	10510443
eISSN	15357732
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.jvir.2025.05.033
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Vascular and Interventional Radiology. 2025
DC.title	Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)
DC.creator	Koretsune, Yuji
	Sone, Miyuki
	Kimura, Shintaro
	Sugawara, Shunsuke
	Kodama, Yoshihisa
	Kimura, Yasushi
	Tanaka, Kaishu
	Ono, Yusuke
	Higashihara, Hiroki
	Arai, Yasuaki
	Kusumoto, Masahiko
	Tomiyama, Noriyuki
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-22
DC.identifier	https://doi.org/10.1016/j.jvir.2025.05.033
DC.description	Koretsune Y., Sone M., Kimura S., et al. Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study). Journal of Vascular and Interventional Radiology , (2025); https://doi.org/10.1016/j.jvir.2025.05.033.
DCTERMS.abstract	Purpose: To investigate the incidence and risk factors of silent brain infarction following transradial hepatic interventional procedures. Materials and Methods: In this multicenter prospective observational study, 57 patients scheduled for transradial hepatic intervention underwent preprocedural and postprocedural magnetic resonance (MR) imaging. The study was divided into 2 periods: August–December 2022 (former group) and June–December 2023 (latter group). In the latter period, selection criteria were modified to include only patients with a left subclavian artery (SCA) angle of >50°, and the protocol was revised to incorporate strict heparinization and continuous catheter flushing. The primary end point was the incidence of silent brain infarction, and associated risk factors were analyzed. Results: Among 57 registered patients, 55 underwent transradial access (TRA). Silent brain infarction was detected in 9 patients (16.4%), with no symptomatic cerebral infarction. The incidence reduced significantly in the latter compared with that in the former group (2.9% vs 40%; P < 0.001). Univariate analysis in the former group demonstrated prolonged catheterization time from the left SCA to descending thoracic aorta as a significant risk factor (575.0 seconds [SD ± 536.2] vs 57.9 seconds [SD ± 59.4]; P = .008), with a cutoff value of 58 seconds (sensitivity, 0.727; specificity, 0.875). Moreover, patients with a left SCA angle of ≤50° demonstrated a significantly higher incidence of silent brain infarction (P = .049). Conclusions: This study demonstrated that transradial hepatic intervention was associated with a 40% incidence of silent brain infarction, which may be reduced by protocols limiting TRA to patients with favorable anatomy and incorporating continuous heparinization and catheter perfusion.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102858
citation_title	Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)
citation_author	Koretsune, Yuji
	Sone, Miyuki
	Kimura, Shintaro
	Sugawara, Shunsuke
	Kodama, Yoshihisa
	Kimura, Yasushi
	Tanaka, Kaishu
	Ono, Yusuke
	Higashihara, Hiroki
	Arai, Yasuaki
	Kusumoto, Masahiko
	Tomiyama, Noriyuki
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2025-10-22
citation_journal_title	Journal of Vascular and Interventional Radiology
citation_doi	https://doi.org/10.1016/j.jvir.2025.05.033
citation_public_url	https://hdl.handle.net/11094/102858

Prospective Multicenter Observational Study of Silent Brain Infarction following Transradial Hepatic Intervention (The MOSAIC Study)

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