Sex differences in placental structure and gene expression in ICR mice during embryonic development

Man, Xinyi; Usui, Noriyoshi; Doi, Miyuki et al.

Scientific Reports, 2025, 15(1), 24067

Number of Access:9（2025-12-03 11:15 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102899

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Title
Sex differences in placental structure and gene expression in ICR mice during embryonic development
Creator
CreatorName
Man, Xinyi
NRID
1000000784076 1000000784076
ORCID
0000-0001-8079-8013 0000-0001-8079-8013
researchmap permalink
noriyoshiusui noriyoshiusui
Scopus Author ID
56404181300 56404181300
CreatorName
Usui, Noriyoshi
NRID
1000080954007 1000080954007
researchmap permalink
doim26 doim26
CreatorName
Doi, Miyuki
NRID
1000020216063 1000020216063
ORCID
0000-0001-5369-1069 0000-0001-5369-1069
researchmap permalink
556shimada 556shimada
Scopus Author ID
35452177800 35452177800
CreatorName
Shimada, Shoichi
Subject
Decidua
Junctional zone
Labyrinth
Placental development
Sex difference
Trophoblast
Description
Man X., Usui N., Doi M., et al. Sex differences in placental structure and gene expression in ICR mice during embryonic development. Scientific Reports 15, 24067 (2025); https://doi.org/10.1038/s41598-025-10476-2.
Abstract
The placenta is a vital organ for fetal development, providing structural support and mediating both nutrient exchange and maternal–fetal immune interactions. However, there are many aspects of murine placental development, which are used as a model organism, that are not fully understood compared to humans. In this study, we examined sex differences in placental development in ICR mice, a commonly used outbred strain, by analyzing the junctional zone (JZ) and labyrinth (LAB) from embryonic day (E) 8.5 to E18.5. At E14.5, the JZ area and its proportion relative to the total placental area (JZ + LAB) were significantly larger in females than in males. Consistently, expression levels of JZ-associated genes were also higher in female placentas at this stage. In contrast, such sex differences in placental morphology and gene expression were not observed in C57BL/6J mice, suggesting that observed features are unique to the ICR strain. Collectively, our findings demonstrate a female-biased expansion of the JZ in ICR mice at mid-gestation and underscore the presence of strain-specific patterns in sex-dependent placental development.
Publisher
Nature Research
Source Title
Scientific Reports
Volume (Issue)
15(1)
Page
24067
Date of Issued
2025-07-05
Language
English
Handle URL
https://hdl.handle.net/11094/102899
eISSN
20452322
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/s41598-025-10476-2
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article