Three-dimensional tooth morphology in patients with tooth agenesis and its association to agenesis pattern, severity, and sex

Tanikawa, Chihiro; Nakamura, Miyuki; Yamashiro, Takashi

Scientific Reports, 2025, 15(1), 28119

Number of Access:24（2025-12-02 11:05 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102914

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Title
Three-dimensional tooth morphology in patients with tooth agenesis and its association to agenesis pattern, severity, and sex
Creator
NRID
1000070423142 1000070423142
ORCID
0000-0003-3390-2900 0000-0003-3390-2900
researchmap permalink
read0091612 read0091612
Scopus Author ID
22837117000 22837117000
CreatorName
Tanikawa, Chihiro
ORCID
0009-0000-3164-3074 0009-0000-3164-3074
Scopus Author ID
60026293000 60026293000
CreatorName
Nakamura, Miyuki
NRID
1000070294428 1000070294428
ORCID
0000-0002-4419-9643 0000-0002-4419-9643
researchmap permalink
read0051793 read0051793
Scopus Author ID
55416765600 55416765600
CreatorName
Yamashiro, Takashi
Subject
Cluster analysis
Dental
Incisor
Japan
Models
Molar
Tooth diseases
Description
Tanikawa C., Nakamura M., Yamashiro T.. Three-dimensional tooth morphology in patients with tooth agenesis and its association to agenesis pattern, severity, and sex. Scientific Reports 15, 28119 (2025); https://doi.org/10.1038/s41598-025-11034-6.
Abstract
Non-syndromic tooth agenesis (TA) can affect both the size and shape of teeth and may interact with sex. This study aimed to advance our understanding of tooth developmental mechanisms by constructing a multifactorial model integrating 3D dental morphology, TA patterns, severity, and sex differences. Digital dental models of 255 Japanese individuals (control: 187; TA: 68) were analyzed. We assessed the contributions of size and shape to sex- and TA-related differences in maxillary central incisors (UI) and first molars (UM) using surface distance mapping and a tooth agenesis-associated shape difference (TAShD) analysis. Additionally, permutation tests were conducted to evaluate the relationship between sex- and TA-associated morphological variation. TA patterns were further classified using k-means clustering, and their associations with 3D tooth morphology were examined. Surface distance maps revealed TA-related morphological traits in both UI and UM, including generalized size reduction, altered cingulum morphology, and diminished distolingual cusps. The TAShD analysis indicated that TA and sex independently influenced tooth shape, although both contributed to size variation. Three distinct TA patterns were identified: Cluster 1 (premolar agenesis) exhibited size reduction without significant shape changes; Cluster 2 (incisor and canine agenesis) showed alterations in both the size and shape of the UI; and Cluster 3 (agenesis of canines, premolars, and second molars) presented with size reduction and shape abnormalities, particularly in the UM. These morphological distinctions across clusters reflect the independent effects of TA and sex on the dental morphology. Collectively, these findings highlight the presence of distinct TA patterns and their associated shape characteristics, thereby offering novel insights into the multifactorial nature of tooth development.
Publisher
Nature Research
Source Title
Scientific Reports
Volume (Issue)
15(1)
Page
28119
Date of Issued
2025-08-01
Language
English
Handle URL
https://hdl.handle.net/11094/102914
eISSN
20452322
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/s41598-025-11034-6
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Version of Record
Category
学術雑誌論文 Journal Article