Obesity and asthma during pregnancy: a systematic review and meta-analysis

Matsuzaki, Hirotaka; Matsuzaki, Shinya; Ueda, Yutaka; Fukuda, Kensuke; Matsuzaki, Satoko; Hiramatsu, Kosuke; Hisa, Tsuyoshi; Okada, Aiko; Mimura, Kazuya; Kage, Hidenori; Kodama, Michiko

doi:https://doi.org/10.1183/16000617.0259-2024

Obesity and asthma during pregnancy: a systematic review and meta-analysis

Matsuzaki, Hirotaka; Matsuzaki, Shinya; Ueda, Yutaka et al.

European Respiratory Review, 2025, 34(176), 240259

Number of Access:3（2025-11-08 20:45 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102931

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
EurRespirRev_34_176_240259	pdf	None	1.06 MB	3	2025.10.31

Creative Commons : Attribution - NonCommercial

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Obesity and asthma during pregnancy: a systematic review and meta-analysis
Creator	NRID 1000000782187 1000000782187 CreatorName Matsuzaki, Hirotaka
	NRID 1000000467565 1000000467565 ORCID 0000-0001-5725-9994 0000-0001-5725-9994 researchmap permalink shinya.matsuzaki shinya.matsuzaki Scopus Author ID 35201668600 35201668600 CreatorName Matsuzaki, Shinya
	NRID 1000010346215 1000010346215 ORCID 0000-0001-8760-6379 0000-0001-8760-6379 researchmap permalink read0092318 read0092318 Scopus Author ID 55087087500 55087087500 CreatorName Ueda, Yutaka
	NRID 1000050910759 1000050910759 CreatorName Fukuda, Kensuke
	CreatorName Matsuzaki, Satoko
	NRID 1000010650591 1000010650591 ORCID 0000-0001-7569-7875 0000-0001-7569-7875 researchmap permalink K12T029771F K12T029771F Scopus Author ID 55371955600 55371955600 CreatorName Hiramatsu, Kosuke
	CreatorName Hisa, Tsuyoshi
	NRID 1000090981267 1000090981267 ORCID 0000-0001-7030-8332 0000-0001-7030-8332 researchmap permalink aiko-okada aiko-okada Scopus Author ID 57193909415 57193909415 CreatorName Okada, Aiko
	NRID 1000050437422 1000050437422 researchmap permalink fm1906 fm1906 Scopus Author ID 17435267000 17435267000 CreatorName Mimura, Kazuya
	NRID 1000080513390 1000080513390 CreatorName Kage, Hidenori
	NRID 1000070791391 1000070791391 ORCID 0000-0003-4046-7572 0000-0003-4046-7572 researchmap permalink mkyh mkyh Scopus Author ID 35422516200 35422516200 CreatorName Kodama, Michiko
Description	Matsuzaki H., Matsuzaki S., Ueda Y., et al. Obesity and asthma during pregnancy: a systematic review and meta-analysis. European Respiratory Review 34, 240259 (2025); https://doi.org/10.1183/16000617.0259-2024.
Abstract	Objective To assess the effect of obesity on the prevalence of asthma, obstetric outcomes and delivery outcomes in pregnant women with asthma. Methods A comprehensive systematic review and meta-analysis were conducted up to 31 March 2024, using four public search engines. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, both quantitative and qualitative data were collected and analysed. Results We included 11 studies from 2006 to 2022 involving 77 611 386 pregnant patients (3.1% had asthma). Obesity increased the odds of asthma (n=2; OR 2.42, 95% CI 1.14–5.15) and increased that of uncontrolled asthma (n=6; OR 1.29, 95% CI 1.11–1.50) in pregnant women. In an adjusted pooled analysis, pregnant women with asthma were more likely to develop hypertensive disorders of pregnancy (HDP) (n=3; adjusted OR (aOR) 1.21, 95% CI 1.10–1.34), gestational diabetes mellitus (GDM) (n=3; aOR 1.14, 95% CI 1.04–1.26), fetal growth restriction (FGR) (n=2; aOR 1.18, 95% CI 1.15–1.21), preterm birth (PTB) (n=2; aOR 1.26, 95% CI 1.25–1.27), caesarean delivery (CD) (n=3; aOR 1.22, 95% CI 1.11– 1.33) and severe maternal morbidity (n=1; aOR 1.50, 95% CI 1.45–1.55). Three comparator studies that examined the effect of obesity on obstetric outcomes cited obesity as a risk factor for HDP (n=1; aOR 1.7, 95% CI 1.3–2.3), GDM (n=1; aOR 4.2, 95% CI 2.8–6.3) and CD (n=1; aOR 1.6, 95% CI 1.3–2.0) in pregnant women with asthma. Conclusions Pregnancy with asthma may increase the risk of HDP, GDM, FGR, PTB and CD, and obesity has the potential to further increase the risk of HDP, GDM and CD in pregnant women with asthma.
Publisher	European Respiratory Society
Source Title	European Respiratory Review
Volume (Issue)	34(176)
Page	240259
Date of Issued	2025-06-11
Language	English
Handle URL	https://hdl.handle.net/11094/102931
PISSN	09059180
eISSN	16000617
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1183/16000617.0259-2024
Access Rights	open access
CopyRight	© the authors 2025. This article is open access and distributed under the terms of the Creative Commons Attribution Non-commercial Licence 4.0.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	European Respiratory Review. 2025, 34(176), p. 240259
DC.title	Obesity and asthma during pregnancy: a systematic review and meta-analysis
DC.creator	Matsuzaki, Hirotaka
	Matsuzaki, Shinya
	Ueda, Yutaka
	Fukuda, Kensuke
	Matsuzaki, Satoko
	Hiramatsu, Kosuke
	Hisa, Tsuyoshi
	Okada, Aiko
	Mimura, Kazuya
	Kage, Hidenori
	Kodama, Michiko
DC.publisher	European Respiratory Society
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-06-11
DC.identifier	https://doi.org/10.1183/16000617.0259-2024
DC.description	Matsuzaki H., Matsuzaki S., Ueda Y., et al. Obesity and asthma during pregnancy: a systematic review and meta-analysis. European Respiratory Review 34, 240259 (2025); https://doi.org/10.1183/16000617.0259-2024.
DCTERMS.abstract	Objective To assess the effect of obesity on the prevalence of asthma, obstetric outcomes and delivery outcomes in pregnant women with asthma. Methods A comprehensive systematic review and meta-analysis were conducted up to 31 March 2024, using four public search engines. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, both quantitative and qualitative data were collected and analysed. Results We included 11 studies from 2006 to 2022 involving 77 611 386 pregnant patients (3.1% had asthma). Obesity increased the odds of asthma (n=2; OR 2.42, 95% CI 1.14–5.15) and increased that of uncontrolled asthma (n=6; OR 1.29, 95% CI 1.11–1.50) in pregnant women. In an adjusted pooled analysis, pregnant women with asthma were more likely to develop hypertensive disorders of pregnancy (HDP) (n=3; adjusted OR (aOR) 1.21, 95% CI 1.10–1.34), gestational diabetes mellitus (GDM) (n=3; aOR 1.14, 95% CI 1.04–1.26), fetal growth restriction (FGR) (n=2; aOR 1.18, 95% CI 1.15–1.21), preterm birth (PTB) (n=2; aOR 1.26, 95% CI 1.25–1.27), caesarean delivery (CD) (n=3; aOR 1.22, 95% CI 1.11– 1.33) and severe maternal morbidity (n=1; aOR 1.50, 95% CI 1.45–1.55). Three comparator studies that examined the effect of obesity on obstetric outcomes cited obesity as a risk factor for HDP (n=1; aOR 1.7, 95% CI 1.3–2.3), GDM (n=1; aOR 4.2, 95% CI 2.8–6.3) and CD (n=1; aOR 1.6, 95% CI 1.3–2.0) in pregnant women with asthma. Conclusions Pregnancy with asthma may increase the risk of HDP, GDM, FGR, PTB and CD, and obesity has the potential to further increase the risk of HDP, GDM and CD in pregnant women with asthma.
DC.rights	© the authors 2025. This article is open access and distributed under the terms of the Creative Commons Attribution Non-commercial Licence 4.0.
DC.format	102931
citation_title	Obesity and asthma during pregnancy: a systematic review and meta-analysis
citation_author	Matsuzaki, Hirotaka
	Matsuzaki, Shinya
	Ueda, Yutaka
	Fukuda, Kensuke
	Matsuzaki, Satoko
	Hiramatsu, Kosuke
	Hisa, Tsuyoshi
	Okada, Aiko
	Mimura, Kazuya
	Kage, Hidenori
	Kodama, Michiko
citation_publisher	European Respiratory Society
citation_language	English
citation_date	2025-06-11
citation_journal_title	European Respiratory Review
citation_volume	34
citation_issue	176
citation_firstpage	240259
citation_doi	https://doi.org/10.1183/16000617.0259-2024
citation_public_url	https://hdl.handle.net/11094/102931

Obesity and asthma during pregnancy: a systematic review and meta-analysis

Link to primary information

Item Information

Show details