Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

Taya, Naohiro; Katakami, Naoto; Omori, Kazuo; Hosoe, Shigero; Watanabe, Hirotaka; Takahara, Mitsuyoshi; Miyashita, Kazuyuki; Konya, Yutaka; Obara, Sachiko; Hidaka, Ayako; Nakao, Motonao; Takahashi, Masatomo; Izumi, Yoshihiro; Bamba, Takeshi; Shimomura, Iichiro

doi:https://doi.org/10.3390/ijms26146977

Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

Taya, Naohiro; Katakami, Naoto; Omori, Kazuo et al.

International Journal of Molecular Sciences, 2025, 26(14), 6977

Number of Access:648（2026-04-26 00:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102933

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
IntJMolSci_26_14_6977	pdf	None	273 KB	39	2025.10.31

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
Creator	NRID 1000000991225 1000000991225 researchmap permalink n-taya n-taya Scopus Author ID 57208973904 57208973904 CreatorName Taya, Naohiro
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 ORCID 0000-0001-9020-8320 0000-0001-9020-8320 CreatorName Katakami, Naoto
	CreatorName Omori, Kazuo
	CreatorName Hosoe, Shigero
	CreatorName Watanabe, Hirotaka
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	NRID 1000030795183 1000030795183 ORCID 0000-0001-7499-9919 0000-0001-7499-9919 researchmap permalink kmiyas kmiyas Scopus Author ID 57192808962 57192808962 CreatorName Miyashita, Kazuyuki
	CreatorName Konya, Yutaka
	CreatorName Obara, Sachiko
	CreatorName Hidaka, Ayako
	CreatorName Nakao, Motonao
	NRID 1000030844419 1000030844419 CreatorName Takahashi, Masatomo
	NRID 1000070622166 1000070622166 CreatorName Izumi, Yoshihiro
	NRID 1000010432444 1000010432444 CreatorName Bamba, Takeshi
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 CreatorName Shimomura, Iichiro
Subject	atherosclerosis
	diacylglycerol
	intima-media thickness
	lipidomics
	type 2 diabetes
Description	Taya N., Katakami N., Omori K., et al. Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis. International Journal of Molecular Sciences 26, 6977 (2025); https://doi.org/10.3390/ijms26146977.
Abstract	Abnormalities in plasma lipoproteins observed in patients with diabetes promote atherosclerosis. However, the association between various lipid species and classes and atherosclerosis remains unclear. Here, we aimed to identify the plasma lipid characteristics associated with atherosclerosis progression in patients with diabetes. We performed semi-targeted lipidomic analysis of fasting plasma samples using supercritical fluid chromatography coupled with mass spectrometry in two independent patient groups with type 2 diabetes (n = 223 and 31) and evaluated cross-sectional associations between plasma lipids and carotid intima-media thickness (CIMT). Ten plasma lipid species, including eight diacylglycerols (DGs), and total DG levels were significantly associated with CIMT in both groups. Patients of the former group were partly observed for 5 years, and we investigated associations between DGs and CIMT progression in these patients (n = 101). As a result, 22 DGs among the 26 identified DGs and total DG (β = 0.398, p < 0.001) were significantly associated with the annual change in CIMT. Furthermore, plasma DG levels improved the predictive ability for CIMT progression, with an adjusted R-squared increase of 0.105 [95% confidence interval: 0.010, 0.232] in the models. Plasma DGs are associated with CIMT progression in patients with type 2 diabetes. Measurement of total plasma DG levels may be beneficial in assessing the risk of atherosclerosis progression.
Publisher	Multidisciplinary Digital Publishing Institute (MDPI)
Source Title	International Journal of Molecular Sciences
Volume (Issue)	26(14)
Page	6977
Date of Issued	2025-07-20
Language	English
Handle URL	https://hdl.handle.net/11094/102933
PISSN	16616596
eISSN	14220067
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/ijms26146977
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2025, 26(14), p. 6977
DC.title	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
DC.creator	Taya, Naohiro
	Katakami, Naoto
	Omori, Kazuo
	Hosoe, Shigero
	Watanabe, Hirotaka
	Takahara, Mitsuyoshi
	Miyashita, Kazuyuki
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-20
DC.identifier	https://doi.org/10.3390/ijms26146977
DC.subject	atherosclerosis
	diacylglycerol
	intima-media thickness
	lipidomics
	type 2 diabetes
DC.description	Taya N., Katakami N., Omori K., et al. Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis. International Journal of Molecular Sciences 26, 6977 (2025); https://doi.org/10.3390/ijms26146977.
DCTERMS.abstract	Abnormalities in plasma lipoproteins observed in patients with diabetes promote atherosclerosis. However, the association between various lipid species and classes and atherosclerosis remains unclear. Here, we aimed to identify the plasma lipid characteristics associated with atherosclerosis progression in patients with diabetes. We performed semi-targeted lipidomic analysis of fasting plasma samples using supercritical fluid chromatography coupled with mass spectrometry in two independent patient groups with type 2 diabetes (n = 223 and 31) and evaluated cross-sectional associations between plasma lipids and carotid intima-media thickness (CIMT). Ten plasma lipid species, including eight diacylglycerols (DGs), and total DG levels were significantly associated with CIMT in both groups. Patients of the former group were partly observed for 5 years, and we investigated associations between DGs and CIMT progression in these patients (n = 101). As a result, 22 DGs among the 26 identified DGs and total DG (β = 0.398, p < 0.001) were significantly associated with the annual change in CIMT. Furthermore, plasma DG levels improved the predictive ability for CIMT progression, with an adjusted R-squared increase of 0.105 [95% confidence interval: 0.010, 0.232] in the models. Plasma DGs are associated with CIMT progression in patients with type 2 diabetes. Measurement of total plasma DG levels may be beneficial in assessing the risk of atherosclerosis progression.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102933
citation_title	Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis
citation_author	Taya, Naohiro
	Katakami, Naoto
	Omori, Kazuo
	Hosoe, Shigero
	Watanabe, Hirotaka
	Takahara, Mitsuyoshi
	Miyashita, Kazuyuki
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	English
citation_date	2025-07-20
citation_journal_title	International Journal of Molecular Sciences
citation_volume	26
citation_issue	14
citation_firstpage	6977
citation_doi	https://doi.org/10.3390/ijms26146977
citation_public_url	https://hdl.handle.net/11094/102933

Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis

Link to primary information

Item Information

Show details