The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis

Kawasaki, Masaya; Shimamoto, Hiroaki; Nishimura, Danielle Ayumi; Yamao, Noriko; Takagawa, Naoko; Uchimoto, Yuka; Takeshita, Ami; Tsujimoto, Tomomi; Kreiborg, Sven; Mallya, Sanjay M.; Yang, Fan pei Gloria; Murakami, Shumei

doi:https://doi.org/10.1038/s41598-025-96910-x

The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis

Kawasaki, Masaya; Shimamoto, Hiroaki; Nishimura, Danielle Ayumi et al.

Scientific Reports, 2025, 15(1), 12272

Number of Access:5（2025-11-13 23:28 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102934

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Title	The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis
Creator	CreatorName Kawasaki, Masaya
	NRID 1000030448112 1000030448112 ORCID 0000-0001-5609-266X 0000-0001-5609-266X researchmap permalink read0127765 read0127765 Scopus Author ID 14026102500 14026102500 CreatorName Shimamoto, Hiroaki
	CreatorName Nishimura, Danielle Ayumi
	CreatorName Yamao, Noriko
	CreatorName Takagawa, Naoko
	NRID 1000051020440 1000051020440 ORCID 0009-0000-6097-9108 0009-0000-6097-9108 researchmap permalink yukauchimoto yukauchimoto Scopus Author ID 57835713500 57835713500 CreatorName Uchimoto, Yuka
	researchmap permalink takeshitaami takeshitaami Scopus Author ID 57836433900 57836433900 CreatorName Takeshita, Ami
	NRID 1000000632150 1000000632150 ORCID 0000-0002-3236-1105 0000-0002-3236-1105 researchmap permalink 6221 6221 Scopus Author ID 36887663900 36887663900 CreatorName Tsujimoto, Tomomi
	CreatorName Kreiborg, Sven
	CreatorName Mallya, Sanjay M.
	CreatorName Yang, Fan pei Gloria
	NRID 1000000263301 1000000263301 ORCID 0000-0003-3977-2422 0000-0003-3977-2422 researchmap permalink shumeimurakami shumeimurakami Scopus Author ID 55519930800 55519930800 CreatorName Murakami, Shumei
Subject	CT
	MRI
	Osteomyelitis
	Panoramic radiography
Description	Kawasaki M., Shimamoto H., Nishimura D.A., et al. The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis. Scientific Reports 15, 12272 (2025); https://doi.org/10.1038/s41598-025-96910-x.
Abstract	To examine the CT-imaging features of subjects with bacterial osteomyelitis (OM), osteoradionecrosis (ORN), and medication-related osteonecrosis of the jaw (MRONJ) with histopathological confirmation, and to examine the diagnostic efficacy of panoramic radiography and MRI in detecting these disease features. 150 cases with preoperative CT data were selected: 61 bacterial OM, 19 ORN, and 70 MRONJ. 143 cases underwent panoramic X-ray examination, and 47 underwent MRI. The assessment criteria for imaging findings included: (1) bone resorption, (2) osteosclerosis, (3) clarity of the mandibular canal, (4) periosteal reactions, (5) cortical bone perforation, (6) sequestrum, and (7) pathological fractures. CT was considered the gold standard for assessing these features. Compared with CT, all panoramic radiographs were detectable for diagnostic features of the disease. Bone resorption was detected in 123 cases (sensitivity 91.1%), and osteosclerosis was detected in 131 cases (sensitivity 98.5%). With panoramic radiography, most changes to clarity of the mandibular canal and pathological fractures were detected (sensitivities of 87.8% and 68.8%, respectively). However, the sensitivities for detection of periosteal reactions, cortical bone perforation and sequestration were low (19.6%, 17.8% and 19.4%, respectively). Sensitivity of MRI for detecting periosteal reactions, cortical bone perforation, sequestration, and pathological fractures (27.3%, 73.5%, 35.7%, and 60.0%, respectively) was equivalent or superior to panoramic imaging. MR-specific characteristics of bone marrow edema were depicted on almost all examinations. Panoramic radiography may be adequate for identifying bone resorption and osteosclerosis. However, MRI provides more value than panoramic radiography in detecting periosteal reactions, cortical bone perforation, sequestration, and bone marrow edema.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	15(1)
Page	12272
Date of Issued	2025-04-10
Language	English
Handle URL	https://hdl.handle.net/11094/102934
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-025-96910-x
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15(1), p. 12272
DC.title	The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis
DC.creator	Kawasaki, Masaya
	Shimamoto, Hiroaki
	Nishimura, Danielle Ayumi
	Yamao, Noriko
	Takagawa, Naoko
	Uchimoto, Yuka
	Takeshita, Ami
	Tsujimoto, Tomomi
	Kreiborg, Sven
	Mallya, Sanjay M.
	Yang, Fan pei Gloria
	Murakami, Shumei
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-04-10
DC.identifier	https://doi.org/10.1038/s41598-025-96910-x
DC.subject	CT
	MRI
	Osteomyelitis
	Panoramic radiography
DC.description	Kawasaki M., Shimamoto H., Nishimura D.A., et al. The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis. Scientific Reports 15, 12272 (2025); https://doi.org/10.1038/s41598-025-96910-x.
DCTERMS.abstract	To examine the CT-imaging features of subjects with bacterial osteomyelitis (OM), osteoradionecrosis (ORN), and medication-related osteonecrosis of the jaw (MRONJ) with histopathological confirmation, and to examine the diagnostic efficacy of panoramic radiography and MRI in detecting these disease features. 150 cases with preoperative CT data were selected: 61 bacterial OM, 19 ORN, and 70 MRONJ. 143 cases underwent panoramic X-ray examination, and 47 underwent MRI. The assessment criteria for imaging findings included: (1) bone resorption, (2) osteosclerosis, (3) clarity of the mandibular canal, (4) periosteal reactions, (5) cortical bone perforation, (6) sequestrum, and (7) pathological fractures. CT was considered the gold standard for assessing these features. Compared with CT, all panoramic radiographs were detectable for diagnostic features of the disease. Bone resorption was detected in 123 cases (sensitivity 91.1%), and osteosclerosis was detected in 131 cases (sensitivity 98.5%). With panoramic radiography, most changes to clarity of the mandibular canal and pathological fractures were detected (sensitivities of 87.8% and 68.8%, respectively). However, the sensitivities for detection of periosteal reactions, cortical bone perforation and sequestration were low (19.6%, 17.8% and 19.4%, respectively). Sensitivity of MRI for detecting periosteal reactions, cortical bone perforation, sequestration, and pathological fractures (27.3%, 73.5%, 35.7%, and 60.0%, respectively) was equivalent or superior to panoramic imaging. MR-specific characteristics of bone marrow edema were depicted on almost all examinations. Panoramic radiography may be adequate for identifying bone resorption and osteosclerosis. However, MRI provides more value than panoramic radiography in detecting periosteal reactions, cortical bone perforation, sequestration, and bone marrow edema.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102934
citation_title	The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis
citation_author	Kawasaki, Masaya
	Shimamoto, Hiroaki
	Nishimura, Danielle Ayumi
	Yamao, Noriko
	Takagawa, Naoko
	Uchimoto, Yuka
	Takeshita, Ami
	Tsujimoto, Tomomi
	Kreiborg, Sven
	Mallya, Sanjay M.
	Yang, Fan pei Gloria
	Murakami, Shumei
citation_publisher	Nature Research
citation_language	English
citation_date	2025-04-10
citation_journal_title	Scientific Reports
citation_volume	15
citation_issue	1
citation_firstpage	12272
citation_doi	https://doi.org/10.1038/s41598-025-96910-x
citation_public_url	https://hdl.handle.net/11094/102934

The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis

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