Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

Iwata, Takamitsu; Nakamura, Hajime; Uemura, Takafumi; Araki, Teppei; Matsumura, Takaki; Abe, Takaaki; Nezu, Toshikazu; Takagaki, Masatoshi; Ozaki, Tomohiko; Miura, Shinpei; Fukuma, Ryohei; John, Sam E.; Grayden, David B.; Kishima, Haruhiko; Sekitani, Tsuyoshi; Yanagisawa, Takufumi

doi:https://doi.org/10.1002/aisy.202500487

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

Iwata, Takamitsu; Nakamura, Hajime; Uemura, Takafumi et al.

Advanced Intelligent Systems, 2025, e202500487

Number of Access:19（2025-11-29 16:41 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102962

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Title	Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness
Creator	CreatorName Iwata, Takamitsu
	NRID 1000080533794 1000080533794 researchmap permalink hnns-osaka hnns-osaka Scopus Author ID 55624478238 55624478238 CreatorName Nakamura, Hajime
	NRID 1000030448097 1000030448097 ORCID 0000-0002-0051-2909 0000-0002-0051-2909 researchmap permalink Takafumi_Uemura Takafumi_Uemura Scopus Author ID 55693535000 55693535000 CreatorName Uemura, Takafumi
	NRID 1000010749518 1000010749518 ORCID 0000-0001-8040-4459 0000-0001-8040-4459 researchmap permalink teppei_araki teppei_araki Scopus Author ID 39261027300 39261027300 CreatorName Araki, Teppei
	NRID 1000080966755 1000080966755 Scopus Author ID 59341372800 59341372800 CreatorName Matsumura, Takaki
	NRID 1000040983424 1000040983424 researchmap permalink taka_abe taka_abe CreatorName Abe, Takaaki
	researchmap permalink tnezu tnezu Scopus Author ID 57192921454 57192921454 CreatorName Nezu, Toshikazu
	NRID 1000070724433 1000070724433 researchmap permalink osakansmt osakansmt Scopus Author ID 46261664000 46261664000 CreatorName Takagaki, Masatoshi
	NRID 1000000723123 1000000723123 ORCID 0000-0003-1558-4785 0000-0003-1558-4785 researchmap permalink tomohikoozaki tomohikoozaki Scopus Author ID 56985206300 56985206300 CreatorName Ozaki, Tomohiko
	NRID 1000050869716 1000050869716 Scopus Author ID 59341294900 59341294900 CreatorName Miura, Shinpei
	NRID 1000020564884 1000020564884 ORCID 0000-0002-3316-9561 0000-0002-3316-9561 researchmap permalink fukuma fukuma Scopus Author ID 47960972500 47960972500 CreatorName Fukuma, Ryohei
	CreatorName John, Sam E.
	CreatorName Grayden, David B.
	NRID 1000010332743 1000010332743 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 CreatorName Kishima, Haruhiko
	NRID 1000080372407 1000080372407 ORCID 0000-0003-1070-2738 0000-0003-1070-2738 researchmap permalink TSS TSS Scopus Author ID 9533002000 9533002000 CreatorName Sekitani, Tsuyoshi
	NRID 1000090533802 1000090533802 ORCID 0000-0002-2057-0612 0000-0002-2057-0612 researchmap permalink takufumi takufumi Scopus Author ID 16553812400 16553812400 CreatorName Yanagisawa, Takufumi
Subject	brain–computer interfaces
	cortical veins
	epilepsy
	intravascular electroencephalography
	minimal invasiveness
Description	Iwata T., Nakamura H., Uemura T., et al. Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness. Advanced Intelligent Systems (2025); https://doi.org/10.1002/aisy.202500487.
Abstract	Intravascular electroencephalography (ivEEG) with microintravascular electrodes enhances neural monitoring, functional mapping, and brain–computer interfaces (BCIs), offering a minimally invasive approach to assess cortical activities; however, this approach remains unrealized. Current ivEEG methods using electrode-attached stents are limited to recording from large vessels, such as the superior sagittal sinus (SSS), restricting access to cortical regions essential for precise BCI control, such as those for hand and mouth movements. Here, ivEEG signals from small and soft cortical veins (CV-ivEEGs) in eight pigs using microintravascular electrodes are recorded, achieving higher resting-state signal power and greater spatial resolution of somatosensory evoked potentials (SEPs) compared to SSS-based ivEEG. Additionally, ivEEG recorded from deep veins clearly captures visual evoked potentials. Furthermore, comparisons between CV-ivEEG and electrocorticography (ECoG) using epidural and subdural electrodes in two pigs demonstrate that CV-ivEEG captures cortical SEPs comparable to ECoG. Targeted electrical stimulation via cortical vein electrodes induces specific contralateral muscle contractions in five anesthetized pigs, confirming selective motor-region stimulation with minimal invasiveness. The findings suggest that ivEEG with microintravascular electrodes is capable of accessing diverse cortical areas and capturing localized neural activity with high signal fidelity for minimally invasive cortical mapping and BCI.
Publisher	John Wiley and Sons Inc
Source Title	Advanced Intelligent Systems
Page	e202500487
Date of Issued	2025-09-12
Language	English
Handle URL	https://hdl.handle.net/11094/102962
eISSN	26404567
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/aisy.202500487
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Advanced Intelligent Systems. 2025, p. e202500487
DC.title	Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness
DC.creator	Iwata, Takamitsu
	Nakamura, Hajime
	Uemura, Takafumi
	Araki, Teppei
	Matsumura, Takaki
	Abe, Takaaki
	Nezu, Toshikazu
	Takagaki, Masatoshi
	Ozaki, Tomohiko
	Miura, Shinpei
	Fukuma, Ryohei
	John, Sam E.
	Grayden, David B.
	Kishima, Haruhiko
	Sekitani, Tsuyoshi
	Yanagisawa, Takufumi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-12
DC.identifier	https://doi.org/10.1002/aisy.202500487
DC.subject	brain–computer interfaces
	cortical veins
	epilepsy
	intravascular electroencephalography
	minimal invasiveness
DC.description	Iwata T., Nakamura H., Uemura T., et al. Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness. Advanced Intelligent Systems (2025); https://doi.org/10.1002/aisy.202500487.
DCTERMS.abstract	Intravascular electroencephalography (ivEEG) with microintravascular electrodes enhances neural monitoring, functional mapping, and brain–computer interfaces (BCIs), offering a minimally invasive approach to assess cortical activities; however, this approach remains unrealized. Current ivEEG methods using electrode-attached stents are limited to recording from large vessels, such as the superior sagittal sinus (SSS), restricting access to cortical regions essential for precise BCI control, such as those for hand and mouth movements. Here, ivEEG signals from small and soft cortical veins (CV-ivEEGs) in eight pigs using microintravascular electrodes are recorded, achieving higher resting-state signal power and greater spatial resolution of somatosensory evoked potentials (SEPs) compared to SSS-based ivEEG. Additionally, ivEEG recorded from deep veins clearly captures visual evoked potentials. Furthermore, comparisons between CV-ivEEG and electrocorticography (ECoG) using epidural and subdural electrodes in two pigs demonstrate that CV-ivEEG captures cortical SEPs comparable to ECoG. Targeted electrical stimulation via cortical vein electrodes induces specific contralateral muscle contractions in five anesthetized pigs, confirming selective motor-region stimulation with minimal invasiveness. The findings suggest that ivEEG with microintravascular electrodes is capable of accessing diverse cortical areas and capturing localized neural activity with high signal fidelity for minimally invasive cortical mapping and BCI.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	102962
citation_title	Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness
citation_author	Iwata, Takamitsu
	Nakamura, Hajime
	Uemura, Takafumi
	Araki, Teppei
	Matsumura, Takaki
	Abe, Takaaki
	Nezu, Toshikazu
	Takagaki, Masatoshi
	Ozaki, Tomohiko
	Miura, Shinpei
	Fukuma, Ryohei
	John, Sam E.
	Grayden, David B.
	Kishima, Haruhiko
	Sekitani, Tsuyoshi
	Yanagisawa, Takufumi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-09-12
citation_journal_title	Advanced Intelligent Systems
citation_firstpage	e202500487
citation_doi	https://doi.org/10.1002/aisy.202500487
citation_public_url	https://hdl.handle.net/11094/102962

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

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