An autopsy case of eosinophilic coronary periarteritis with coronary arterial degeneration and repaired dissection

Yoshizawa, Hidenori; Ikeda, Yoshihiko; Morii, Eiich et al.

Journal of Forensic and Legal Medicine, 2025, 115, 102977

Number of Access:135（2026-02-05 21:42 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103288

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Title
An autopsy case of eosinophilic coronary periarteritis with coronary arterial degeneration and repaired dissection
Creator
NRID
1000090739905 1000090739905
Scopus Author ID
57220751203 57220751203
CreatorName
Yoshizawa, Hidenori
NRID
1000030393242 1000030393242
CreatorName
Ikeda, Yoshihiko
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
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Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiich
NRID
1000060325735 1000060325735
CreatorName
Hatakeyama, Kinta
Subject
Cystic medial necrosis (CMN)
Eosinophilic coronary periarteritis (ECPA)
Spontaneous coronary artery dissection (SCAD)
Description
Yoshizawa H., Ikeda Y., Morii E., et al. An autopsy case of eosinophilic coronary periarteritis with coronary arterial degeneration and repaired dissection. Journal of Forensic and Legal Medicine 115, 102977 (2025); https://doi.org/10.1016/j.jflm.2025.102977.
Abstract
Eosinophilic coronary periarteritis (ECPA) is a rare disease, almost exclusively diagnosed postmortem, characterized by a clinical course of vasospastic angina (VSA) attacks and histologically observed periarterial eosinophilic infiltration in the coronary arteries. Although the etiology of ECPA remains uncertain, its pathogenesis may be attributed to an allergic reaction. In addition, ECPA is often associated with spontaneous coronary artery dissection (SCAD); however, the pathogenesis underlying the link between inflammation and dissection remains unclear.In the current case, a 45-year-old female experienced VSA attacks and succumbed to a fatal exacerbation of VSA approximately six years after the first onset of symptoms. Pathological examination at autopsy revealed periarterial eosinophilic infiltration in the coronary artery, suggesting ECPA. Characteristically, the pathological findings further showed localized SCAD with a repair response and deposition of a degenerative matrix in the tunica media. These findings may provide insights into the pathogenesis of ECPA.This case highlights the importance of autopsy examinations for discussing and elucidating the pathophysiology of ECPA.
Publisher
Churchill Livingstone
Source Title
Journal of Forensic and Legal Medicine
Volume (Issue)
115
Page
102977
Date of Issued
2025-09-24
Language
English
Handle URL
https://hdl.handle.net/11094/103288
PISSN
1752928X
eISSN
18787487
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.jflm.2025.102977
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Version of Record
Category
学術雑誌論文 Journal Article