Photoinitiator-Free Two-Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication

Nakayama, Atsushi; Kumamoto, Yasuaki; Minoshima, Masafumi et al.

Advanced Optical Materials, 2023, 10(18), 2200474

Number of Access:198（2026-02-18 23:54 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103304

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Title
Photoinitiator-Free Two-Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication
Creator
CreatorName
Nakayama, Atsushi
NRID
1000030611727 1000030611727
ORCID
0000-0002-4398-288X 0000-0002-4398-288X
researchmap permalink
jemappellekuma jemappellekuma
Scopus Author ID
24376935000 24376935000
CreatorName
Kumamoto, Yasuaki
NRID
1000020600844 1000020600844
ORCID
0000-0002-9352-3454 0000-0002-9352-3454
researchmap permalink
cbatgcm_m33 cbatgcm_m33
Scopus Author ID
12774750700 12774750700
CreatorName
Minoshima, Masafumi
NRID
1000070292951 1000070292951
researchmap permalink
kikuchilab315 kikuchilab315
Scopus Author ID
7404088901 7404088901
CreatorName
Kikuchi, Kazuya
NRID
1000070532109 1000070532109
CreatorName
Taguchi, Atsushi
NRID
1000080362664 1000080362664
ORCID
0000-0002-2284-375X 0000-0002-2284-375X
researchmap permalink
read0089911 read0089911
Scopus Author ID
7404058829 7404058829
CreatorName
Fujita, Katsumasa
Subject
collagen
DUV absorption
hydrogel
initiator-free
two-photon polymerization
Description
This is the peer reviewed version of the following article: Nakayama A., Kumamoto Y., Minoshima M., et al. Photoinitiator-Free Two-Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication. Advanced Optical Materials 10, 2200474 (2022), which has been published in final form at https://doi.org/10.1002/adom.202200474. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Abstract
Two-photon polymerization is expected to realize the fabrication of biological tissues for regenerative medicine and drug development because of its capability of 3D fabrication with submicrometer spatial resolution. However, photopolymerization initiators generally added to resins have low biocompatibility and water solubility, which pose a challenge for the biological application of micro- and nanostructures fabricated by photopolymerization. In this study, two-photon polymerization is performed using biocompatible materials without photoinitiators and the preservation of the material properties of the fabricated 3D structures is evaluated. Poly(ethylene glycol) diacrylate (PEGda) and collagen are successfully fabricated using a femtosecond pulsed laser at a wavelength of 400 nm with a feature size of 100 nm without photoinitiator. The excitation intensities required for the polymerization of PEGda and collagen are about 450 and 150 kW cm⁻², respectively, which are smaller than those reported with using photoinitiators. Raman spectroscopy is used to confirm that the water-swelling polymer network of PEGda and the enzymatic degradation of collagen, which are important factors in the application with live cells, are maintained in the fabricated structures.
Publisher
John Wiley and Sons Inc
Source Title
Advanced Optical Materials
Volume (Issue)
10(18)
Page
2200474
Date of Issued
2023-07-01
Language
English
Handle URL
https://hdl.handle.net/11094/103304
eISSN
21951071
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1002/adom.202200474
Access Rights
open access
CopyRight
© 2022 Wiley-VCH GmbH
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article