Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study

Tachibana, Yuka; Kobayashi, Keigo; Kabayama, Mai; Kido, Michiko; Akagi, Yuya; Akasaka, Hiroshi; Iwashima, Yoshio; Yasumoto, Saori; Masui, Yukie; Ikebe, Kazunori; Hirata, Takumi; Arai, Yasumichi; Gondo, Yasuyuki; Yamamoto, Koichi; Kamide, Kei

doi:https://doi.org/10.1016/j.archger.2025.106109

Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study

Tachibana, Yuka; Kobayashi, Keigo; Kabayama, Mai et al.

Archives of Gerontology and Geriatrics, 2026, 142, 106109

Number of Access:11（2026-01-28 22:05 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103576

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Title	Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study
Creator	NRID 1000041001233 1000041001233 CreatorName Tachibana, Yuka
	researchmap permalink keigo-kobayashi keigo-kobayashi Scopus Author ID 59709700800 59709700800 CreatorName Kobayashi, Keigo
	NRID 1000050635498 1000050635498 ORCID 0000-0003-1394-1152 0000-0003-1394-1152 researchmap permalink kabayama kabayama Scopus Author ID 57031780400 57031780400 CreatorName Kabayama, Mai
	NRID 1000000706913 1000000706913 researchmap permalink 051010 051010 Scopus Author ID 56086201900 56086201900 CreatorName Kido, Michiko
	ORCID 0000-0001-7974-9580 0000-0001-7974-9580 researchmap permalink yuya-akagi yuya-akagi Scopus Author ID 57205223200 57205223200 CreatorName Akagi, Yuya
	NRID 1000070468081 1000070468081 researchmap permalink hiroshi-akasaka hiroshi-akasaka Scopus Author ID 35445539600 35445539600 CreatorName Akasaka, Hiroshi
	NRID 1000080448068 1000080448068 researchmap permalink 7106 7106 Scopus Author ID 7004119377 7004119377 CreatorName Iwashima, Yoshio
	NRID 1000060649317 1000060649317 researchmap permalink GSU GSU Scopus Author ID 36503185600 36503185600 CreatorName Yasumoto, Saori
	NRID 1000010415507 1000010415507 CreatorName Masui, Yukie
	NRID 1000070273696 1000070273696 ORCID 0000-0001-5696-6785 0000-0001-5696-6785 researchmap permalink read0185241 read0185241 Scopus Author ID 35494649700 35494649700 CreatorName Ikebe, Kazunori
	NRID 1000000383795 1000000383795 CreatorName Hirata, Takumi
	NRID 1000020255467 1000020255467 CreatorName Arai, Yasumichi
	NRID 1000040250196 1000040250196 ORCID 0000-0002-9805-2807 0000-0002-9805-2807 researchmap permalink ygondo ygondo Scopus Author ID 55800810400 55800810400 CreatorName Gondo, Yasuyuki
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 CreatorName Yamamoto, Koichi
	NRID 1000080393239 1000080393239 ORCID 0000-0003-1720-2218 0000-0003-1720-2218 researchmap permalink kamide kamide Scopus Author ID 7102978326 7102978326 CreatorName Kamide, Kei
Subject	Cognitive decline
	Sex differences
	Vital capacity
Description	Tachibana Y., Kobayashi K., Kabayama M., et al. Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study. Archives of Gerontology and Geriatrics 142, 106109 (2026); https://doi.org/10.1016/j.archger.2025.106109.
Abstract	Reduced pulmonary function may contribute to cognitive decline in older adults; however, few longitudinal studies adjust for frailty, lifestyle, and comorbidities. This study examined whether baseline spirometry predicts 3-year cognitive decline in community-dwelling older Japanese adults. Data were derived from the SONIC Study, a longitudinal cohort of older Japanese adults. This 3-year follow-up included community-dwelling adults in their 70 s and 80 s, stratified by age and sex. Baseline and follow-up assessed anthropometry, physical frailty indicators (grip strength and gait speed), cognition (Montreal Cognitive Assessment, Japanese version [MoCA-J]) and pulmonary function (percent vital capacity [%VC], percent forced vital capacity [%FVC], percent forced expiratory volume in one second [%FEV₁], forced expiratory volume in one second / forced vital capacity ratio [FEV₁/FVC], and percent peak expiratory flow [%PEF]). Associations with mild cognitive decline were examined using logistic regression, adjusted for comorbidities, health behaviors, and frailty. Most pulmonary function measures markedly decreased over 3 years, whereas the FEV₁/FVC ratio remained stable. MoCA-J scores markedly declined among adults in their 80 s but remained stable in those in their 70 s. Reduced %PEF was markedly associated with cognitive decline only in participants in their 70 s, in males and females. Additionally, reduced FEV₁/FVC ratio was associated with increased cognitive decline in females in their 70 s. No significant associations were found in participants in their 80 s. In older adults, declines in %PEF and FEV₁/FVC ratio increased cognitive decline in the 70 s age group, with sex differences noted. Simple pulmonary measures may help identify those at risk.
Publisher	Elsevier Ireland Ltd
Source Title	Archives of Gerontology and Geriatrics
Volume (Issue)	142
Page	106109
Date of Issued	2026-03-01
Language	English
Handle URL	https://hdl.handle.net/11094/103576
PISSN	01674943
eISSN	18726976
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.archger.2025.106109
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Archives of Gerontology and Geriatrics. 2026, 142, p. 106109
DC.title	Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study
DC.creator	Tachibana, Yuka
	Kobayashi, Keigo
	Kabayama, Mai
	Kido, Michiko
	Akagi, Yuya
	Akasaka, Hiroshi
	Iwashima, Yoshio
	Yasumoto, Saori
	Masui, Yukie
	Ikebe, Kazunori
	Hirata, Takumi
	Arai, Yasumichi
	Gondo, Yasuyuki
	Yamamoto, Koichi
	Kamide, Kei
DC.publisher	Elsevier Ireland Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-03-01
DC.identifier	https://doi.org/10.1016/j.archger.2025.106109
DC.subject	Cognitive decline
	Sex differences
	Vital capacity
DC.description	Tachibana Y., Kobayashi K., Kabayama M., et al. Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study. Archives of Gerontology and Geriatrics 142, 106109 (2026); https://doi.org/10.1016/j.archger.2025.106109.
DCTERMS.abstract	Reduced pulmonary function may contribute to cognitive decline in older adults; however, few longitudinal studies adjust for frailty, lifestyle, and comorbidities. This study examined whether baseline spirometry predicts 3-year cognitive decline in community-dwelling older Japanese adults. Data were derived from the SONIC Study, a longitudinal cohort of older Japanese adults. This 3-year follow-up included community-dwelling adults in their 70 s and 80 s, stratified by age and sex. Baseline and follow-up assessed anthropometry, physical frailty indicators (grip strength and gait speed), cognition (Montreal Cognitive Assessment, Japanese version [MoCA-J]) and pulmonary function (percent vital capacity [%VC], percent forced vital capacity [%FVC], percent forced expiratory volume in one second [%FEV₁], forced expiratory volume in one second / forced vital capacity ratio [FEV₁/FVC], and percent peak expiratory flow [%PEF]). Associations with mild cognitive decline were examined using logistic regression, adjusted for comorbidities, health behaviors, and frailty. Most pulmonary function measures markedly decreased over 3 years, whereas the FEV₁/FVC ratio remained stable. MoCA-J scores markedly declined among adults in their 80 s but remained stable in those in their 70 s. Reduced %PEF was markedly associated with cognitive decline only in participants in their 70 s, in males and females. Additionally, reduced FEV₁/FVC ratio was associated with increased cognitive decline in females in their 70 s. No significant associations were found in participants in their 80 s. In older adults, declines in %PEF and FEV₁/FVC ratio increased cognitive decline in the 70 s age group, with sex differences noted. Simple pulmonary measures may help identify those at risk.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	103576
citation_title	Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study
citation_author	Tachibana, Yuka
	Kobayashi, Keigo
	Kabayama, Mai
	Kido, Michiko
	Akagi, Yuya
	Akasaka, Hiroshi
	Iwashima, Yoshio
	Yasumoto, Saori
	Masui, Yukie
	Ikebe, Kazunori
	Hirata, Takumi
	Arai, Yasumichi
	Gondo, Yasuyuki
	Yamamoto, Koichi
	Kamide, Kei
citation_publisher	Elsevier Ireland Ltd
citation_language	English
citation_date	2026-03-01
citation_journal_title	Archives of Gerontology and Geriatrics
citation_volume	142
citation_firstpage	106109
citation_doi	https://doi.org/10.1016/j.archger.2025.106109
citation_public_url	https://hdl.handle.net/11094/103576

Longitudinal association between pulmonary function and incident cognitive decline: Results of the SONIC cohort study

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