Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders

Kamada, Yoshihiro; Fujii, Makoto; Nishizawa, Hitoshi; Fukuda, Shiro; Yamada, Makoto; Shimomura, Iichiro; Miyoshi, Eiji

doi:https://doi.org/10.1111/hepr.70088

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders

Kamada, Yoshihiro; Fujii, Makoto; Nishizawa, Hitoshi et al.

Hepatology Research, 2025

Number of Access:131（2026-04-04 12:44 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103706

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Title	Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders
Creator	NRID 1000030622609 1000030622609 ORCID 0000-0001-5485-902X 0000-0001-5485-902X researchmap permalink yk4478-jp yk4478-jp Scopus Author ID 7102943545 7102943545 CreatorName Kamada, Yoshihiro
	NRID 1000010803760 1000010803760 ORCID 0000-0003-4436-7456 0000-0003-4436-7456 researchmap permalink m-fujii m-fujii Scopus Author ID 55738467300 55738467300 CreatorName Fujii, Makoto
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	NRID 1000000896467 1000000896467 ORCID 0000-0003-0712-7154 0000-0003-0712-7154 researchmap permalink sfukuda-ou sfukuda-ou Scopus Author ID 55766129200 55766129200 CreatorName Fukuda, Shiro
	CreatorName Yamada, Makoto
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 CreatorName Shimomura, Iichiro
	NRID 1000020322183 1000020322183 ORCID 0000-0002-9430-2362 0000-0002-9430-2362 researchmap permalink read0068532 read0068532 Scopus Author ID 7005784183 7005784183 CreatorName Miyoshi, Eiji
Subject	dyslipidemia
	hypertension
	MASLD/MASH
	obesity
	type 2 diabetes mellitus
Description	Kamada Y., Fujii M., Nishizawa H., et al. Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders. Hepatology Research (2025); https://doi.org/10.1111/hepr.70088.
Abstract	Background: Steatotic liver disease (SLD) is a hepatic phenotype of metabolic syndrome (MetS). However, little is known about the relationship between SLD and the onset of each MetS-related disease (type 2 diabetes [T2D], hypertension, and dyslipidemia). In this study, we examined the relationship between the onset of MetS-related diseases and SLD using health checkup data at baseline and 7 years later. Methods: A total of 2167 individuals who underwent a health examination were initially recruited to the study. After excluding cases with a history of hepatic disease, a total of 714 subjects were selected and received an abdominal ultrasound test at baseline and again 7 years later. New-onset cases were defined as subjects who were free of each disease at baseline but developed one by the 7-year follow-up. Logistic regression analysis was used to estimate odds ratios and quantify the impact of SLD on the development of MetS-related diseases. Results: We found the following results: (1) SLD at baseline is an independent risk factor for the incidence of MetS-related disease 7 years later. (2) T2D and hypertension are not independent risk factors for the incidence of SLD 7 years later. Dyslipidemia and obesity are independent risk factors for the incidence of SLD. Obesity is the only independent risk factor for the new development of SLD within 7 years. (3) No individual MetS-related disease is an independent risk factor for the development of SLD. Conclusion: The presence of SLD is more associated with the incidence of MetS-related diseases than obesity.
Publisher	John Wiley and Sons Inc
Source Title	Hepatology Research
Date of Issued	2025-12-04
Language	English
Handle URL	https://hdl.handle.net/11094/103706
PISSN	13866346
eISSN	1872034X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/hepr.70088
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Hepatology Research. 2025
DC.title	Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders
DC.creator	Kamada, Yoshihiro
	Fujii, Makoto
	Nishizawa, Hitoshi
	Fukuda, Shiro
	Yamada, Makoto
	Shimomura, Iichiro
	Miyoshi, Eiji
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-12-04
DC.identifier	https://doi.org/10.1111/hepr.70088
DC.subject	dyslipidemia
	hypertension
	MASLD/MASH
	obesity
	type 2 diabetes mellitus
DC.description	Kamada Y., Fujii M., Nishizawa H., et al. Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders. Hepatology Research (2025); https://doi.org/10.1111/hepr.70088.
DCTERMS.abstract	Background: Steatotic liver disease (SLD) is a hepatic phenotype of metabolic syndrome (MetS). However, little is known about the relationship between SLD and the onset of each MetS-related disease (type 2 diabetes [T2D], hypertension, and dyslipidemia). In this study, we examined the relationship between the onset of MetS-related diseases and SLD using health checkup data at baseline and 7 years later. Methods: A total of 2167 individuals who underwent a health examination were initially recruited to the study. After excluding cases with a history of hepatic disease, a total of 714 subjects were selected and received an abdominal ultrasound test at baseline and again 7 years later. New-onset cases were defined as subjects who were free of each disease at baseline but developed one by the 7-year follow-up. Logistic regression analysis was used to estimate odds ratios and quantify the impact of SLD on the development of MetS-related diseases. Results: We found the following results: (1) SLD at baseline is an independent risk factor for the incidence of MetS-related disease 7 years later. (2) T2D and hypertension are not independent risk factors for the incidence of SLD 7 years later. Dyslipidemia and obesity are independent risk factors for the incidence of SLD. Obesity is the only independent risk factor for the new development of SLD within 7 years. (3) No individual MetS-related disease is an independent risk factor for the development of SLD. Conclusion: The presence of SLD is more associated with the incidence of MetS-related diseases than obesity.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	103706
citation_title	Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders
citation_author	Kamada, Yoshihiro
	Fujii, Makoto
	Nishizawa, Hitoshi
	Fukuda, Shiro
	Yamada, Makoto
	Shimomura, Iichiro
	Miyoshi, Eiji
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2025-12-04
citation_journal_title	Hepatology Research
citation_doi	https://doi.org/10.1111/hepr.70088
citation_public_url	https://hdl.handle.net/11094/103706

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome-Related Disorders

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