Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry

Hosoe, Shigero; Katakami, Naoto; Taya, Naohiro; Omori, Kazuo; Takahara, Mitsuyoshi; Konya, Yutaka; Obara, Sachiko; Hidaka, Ayako; Nakao, Motonao; Takahashi, Masatomo; Izumi, Yoshihiro; Bamba, Takeshi; Shimomura, Iichiro

doi:https://doi.org/10.2337/db25-0099

Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry

Hosoe, Shigero; Katakami, Naoto; Taya, Naohiro et al.

Diabetes, 2025, 74(10), 1839-1849

Number of Access:206（2026-04-26 00:08 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103801

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Title	Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry
Creator	CreatorName Hosoe, Shigero
	NRID 1000010403049 1000010403049 ORCID 0000-0001-9020-8320 0000-0001-9020-8320 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 CreatorName Katakami, Naoto
	NRID 1000000991225 1000000991225 researchmap permalink n-taya n-taya Scopus Author ID 57208973904 57208973904 CreatorName Taya, Naohiro
	CreatorName Omori, Kazuo
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	CreatorName Konya, Yutaka
	CreatorName Obara, Sachiko
	CreatorName Hidaka, Ayako
	CreatorName Nakao, Motonao
	NRID 1000030844419 1000030844419 CreatorName Takahashi, Masatomo
	NRID 1000070622166 1000070622166 ORCID 0000-0003-4608-4652 0000-0003-4608-4652 researchmap permalink izumi_yoshihiro izumi_yoshihiro Scopus Author ID 49561344400 49561344400 CreatorName Izumi, Yoshihiro
	NRID 1000010432444 1000010432444 CreatorName Bamba, Takeshi
	NRID 1000060346145 1000060346145 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 CreatorName Shimomura, Iichiro
Description	Hosoe S., Katakami N., Taya N., et al. Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry. Diabetes 74, 1839 (2025); https://doi.org/10.2337/db25-0099.
Abstract	This study aimed to investigate the relationship between the plasma lipidome and metabolic dysfunction– associated steatotic liver disease (MASLD) in type 2 diabetes. Initially, we conducted a plasma lipidome analysis using supercritical fluid chromatography–tandem mass spectrometry in 143 patients with type 2 diabetes with and without MASLD. Of the 349 lipid species identified, 13 had higher levels and a fold-change ≥2 in the MASLD group than in the non-MASLD group; 10 of these 13 lipids were triglycerides (TGs). The constituent fatty acid (FA) in TGs that exhibited the greatest difference between patients with and without MASLD was myristic acid (FA 14:0). The presence of MASLD was an independent explanatory factor for high FA 14:0 levels in TGs, even after adjusting for covariates. Next, we assessed whether the levels of lipids identified in the initial analysis were influenced by comprehensive diabetes treatment in 26 patients. After comprehensive diabetes treatment of 2 weeks, FA levels in many TGs significantly decreased; especially FA 14:0 levels, and this reduction was more pronounced in patients with MASLD. These results suggest that various plasma lipids, particularly TGs comprising FA 14:0, may be associated with the pathogenesis of MASLD in patients with type 2 diabetes.
Publisher	American Diabetes Association Inc.
Source Title	Diabetes
Volume (Issue)	74(10)
Page	1839-1849
Date of Issued	2025-08-14
Language	English
Handle URL	https://hdl.handle.net/11094/103801
PISSN	00121797
eISSN	1939327X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.2337/db25-0099
Access Rights	open access
CopyRight	© 2025 by the American Diabetes Association
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Diabetes. 2025, 74(10), p. 1839-1849
DC.title	Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry
DC.creator	Hosoe, Shigero
	Katakami, Naoto
	Taya, Naohiro
	Omori, Kazuo
	Takahara, Mitsuyoshi
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
DC.publisher	American Diabetes Association Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-08-14
DC.identifier	https://doi.org/10.2337/db25-0099
DC.description	Hosoe S., Katakami N., Taya N., et al. Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry. Diabetes 74, 1839 (2025); https://doi.org/10.2337/db25-0099.
DCTERMS.abstract	This study aimed to investigate the relationship between the plasma lipidome and metabolic dysfunction– associated steatotic liver disease (MASLD) in type 2 diabetes. Initially, we conducted a plasma lipidome analysis using supercritical fluid chromatography–tandem mass spectrometry in 143 patients with type 2 diabetes with and without MASLD. Of the 349 lipid species identified, 13 had higher levels and a fold-change ≥2 in the MASLD group than in the non-MASLD group; 10 of these 13 lipids were triglycerides (TGs). The constituent fatty acid (FA) in TGs that exhibited the greatest difference between patients with and without MASLD was myristic acid (FA 14:0). The presence of MASLD was an independent explanatory factor for high FA 14:0 levels in TGs, even after adjusting for covariates. Next, we assessed whether the levels of lipids identified in the initial analysis were influenced by comprehensive diabetes treatment in 26 patients. After comprehensive diabetes treatment of 2 weeks, FA levels in many TGs significantly decreased; especially FA 14:0 levels, and this reduction was more pronounced in patients with MASLD. These results suggest that various plasma lipids, particularly TGs comprising FA 14:0, may be associated with the pathogenesis of MASLD in patients with type 2 diabetes.
DC.rights	© 2025 by the American Diabetes Association
DC.format	103801
citation_title	Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry
citation_author	Hosoe, Shigero
	Katakami, Naoto
	Taya, Naohiro
	Omori, Kazuo
	Takahara, Mitsuyoshi
	Konya, Yutaka
	Obara, Sachiko
	Hidaka, Ayako
	Nakao, Motonao
	Takahashi, Masatomo
	Izumi, Yoshihiro
	Bamba, Takeshi
	Shimomura, Iichiro
citation_publisher	American Diabetes Association Inc.
citation_language	English
citation_date	2025-08-14
citation_journal_title	Diabetes
citation_volume	74
citation_issue	10
citation_firstpage	1839
citation_lastpage	1849
citation_doi	https://doi.org/10.2337/db25-0099
citation_public_url	https://hdl.handle.net/11094/103801

Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry

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