Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale

Dohi, Tomoharu; Ishihara, Takayuki; Kida, Hirota; Nakamura, Daisuke; Kikuchi, Atsushi; Kawai, Tsutomu; Mori, Naoki; Okamoto, Naotaka; Ueda, Yasunori; Shutta, Ryu; Ichikawa, Minoru; Mano, Toshiaki; Watanabe, Tetsuya; Higuchi, Yoshiharu; Nishino, Masami; Hida, Eisuke; Sato, Tomoharu; Hikoso, Shungo; Nakatani, Daisaku; Sotomi, Yohei; Sakata, Yasushi

doi:https://doi.org/10.1016/j.carrev.2025.03.024

Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale

Dohi, Tomoharu; Ishihara, Takayuki; Kida, Hirota et al.

Cardiovascular Revascularization Medicine, 2025, 81, 57-61

Number of Access:124（2026-04-05 10:12 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/103888

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Title	Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale
Creator	NRID 1000090838137 1000090838137 researchmap permalink dohi_1230 dohi_1230 Scopus Author ID 35071263000 35071263000 CreatorName Dohi, Tomoharu
	CreatorName Ishihara, Takayuki
	CreatorName Kida, Hirota
	NRID 1000030869970 1000030869970 researchmap permalink daifromn0525 daifromn0525 CreatorName Nakamura, Daisuke
	CreatorName Kikuchi, Atsushi
	CreatorName Kawai, Tsutomu
	CreatorName Mori, Naoki
	CreatorName Okamoto, Naotaka
	CreatorName Ueda, Yasunori
	CreatorName Shutta, Ryu
	CreatorName Ichikawa, Minoru
	CreatorName Mano, Toshiaki
	NRID 1000060897825 1000060897825 CreatorName Watanabe, Tetsuya
	CreatorName Higuchi, Yoshiharu
	CreatorName Nishino, Masami
	NRID 1000030469952 1000030469952 ORCID 0000-0001-9381-2013 0000-0001-9381-2013 researchmap permalink ehida ehida Scopus Author ID 57190171039 57190171039 CreatorName Hida, Eisuke
	NRID 1000080865220 1000080865220 CreatorName Sato, Tomoharu
	NRID 1000030423164 1000030423164 ORCID 0000-0003-2284-1970 0000-0003-2284-1970 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 57578643800 57578643800 CreatorName Hikoso, Shungo
	NRID 1000060444535 1000060444535 ORCID 0000-0002-1534-2033 0000-0002-1534-2033 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 CreatorName Nakatani, Daisaku
	NRID 1000090885253 1000090885253 ORCID 0000-0002-7564-2978 0000-0002-7564-2978 researchmap permalink sotomiyohei sotomiyohei Scopus Author ID 57115149800 57115149800 CreatorName Sotomi, Yohei
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	Bifurcation
	Coronary intervention
	Drug-coated balloon
	Open-label randomized controlled trial
	Restenosis
Description	Dohi T., Ishihara T., Kida H., et al. Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale. Cardiovascular Revascularization Medicine 81, 57 (2025); https://doi.org/10.1016/j.carrev.2025.03.024.
Abstract	Background Although several clinical trials have suggested the usefulness of drug-coated balloons (DCB) for side-branch lesions, their efficacy and safety have not yet been established. Methods and study design The Osaka Cardiovascular Conference (OCVC) will conduct a multicenter, randomized, open-label, controlled trial aiming to examine whether additional DCB treatment for the side branch after main vessel stenting followed by kissing balloon inflation (KBI) is superior to only KBI by conventional balloons in PCI patients with coronary bifurcation lesions. The primary endpoint is restenosis of side branches documented by scheduled or symptom-driven coronary angiography during 9-month follow-up period after the index PCI. The key secondary endpoints include major adverse cardiac event which consists of cardiac death, myocardial infarction, target lesion revascularization, and stent thrombosis, and optical coherence tomography findings. A total of 300 patients will be enrolled and followed up to 1 year. Summary The OCVC-BIF trial is a randomized controlled trial designed to assess whether additional DCB treatment for side branch is superior to only KBI by conventional balloons in patients with coronary bifurcation lesions undergoing PCI with main vessel stenting.
Publisher	Elsevier Inc.
Source Title	Cardiovascular Revascularization Medicine
Volume (Issue)	81
Page	57-61
Date of Issued	2025-12-10
Language	English
Handle URL	https://hdl.handle.net/11094/103888
PISSN	15538389
eISSN	18780938
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.carrev.2025.03.024
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Cardiovascular Revascularization Medicine. 2025, 81, p. 57-61
DC.title	Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale
DC.creator	Dohi, Tomoharu
	Ishihara, Takayuki
	Kida, Hirota
	Nakamura, Daisuke
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Mori, Naoki
	Okamoto, Naotaka
	Ueda, Yasunori
	Shutta, Ryu
	Ichikawa, Minoru
	Mano, Toshiaki
	Watanabe, Tetsuya
	Higuchi, Yoshiharu
	Nishino, Masami
	Hida, Eisuke
	Sato, Tomoharu
	Hikoso, Shungo
	Nakatani, Daisaku
	Sotomi, Yohei
	Sakata, Yasushi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-12-10
DC.identifier	https://doi.org/10.1016/j.carrev.2025.03.024
DC.subject	Bifurcation
	Coronary intervention
	Drug-coated balloon
	Open-label randomized controlled trial
	Restenosis
DC.description	Dohi T., Ishihara T., Kida H., et al. Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale. Cardiovascular Revascularization Medicine 81, 57 (2025); https://doi.org/10.1016/j.carrev.2025.03.024.
DCTERMS.abstract	Background Although several clinical trials have suggested the usefulness of drug-coated balloons (DCB) for side-branch lesions, their efficacy and safety have not yet been established. Methods and study design The Osaka Cardiovascular Conference (OCVC) will conduct a multicenter, randomized, open-label, controlled trial aiming to examine whether additional DCB treatment for the side branch after main vessel stenting followed by kissing balloon inflation (KBI) is superior to only KBI by conventional balloons in PCI patients with coronary bifurcation lesions. The primary endpoint is restenosis of side branches documented by scheduled or symptom-driven coronary angiography during 9-month follow-up period after the index PCI. The key secondary endpoints include major adverse cardiac event which consists of cardiac death, myocardial infarction, target lesion revascularization, and stent thrombosis, and optical coherence tomography findings. A total of 300 patients will be enrolled and followed up to 1 year. Summary The OCVC-BIF trial is a randomized controlled trial designed to assess whether additional DCB treatment for side branch is superior to only KBI by conventional balloons in patients with coronary bifurcation lesions undergoing PCI with main vessel stenting.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103888
citation_title	Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale
citation_author	Dohi, Tomoharu
	Ishihara, Takayuki
	Kida, Hirota
	Nakamura, Daisuke
	Kikuchi, Atsushi
	Kawai, Tsutomu
	Mori, Naoki
	Okamoto, Naotaka
	Ueda, Yasunori
	Shutta, Ryu
	Ichikawa, Minoru
	Mano, Toshiaki
	Watanabe, Tetsuya
	Higuchi, Yoshiharu
	Nishino, Masami
	Hida, Eisuke
	Sato, Tomoharu
	Hikoso, Shungo
	Nakatani, Daisaku
	Sotomi, Yohei
	Sakata, Yasushi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2025-12-10
citation_journal_title	Cardiovascular Revascularization Medicine
citation_volume	81
citation_firstpage	57
citation_lastpage	61
citation_doi	https://doi.org/10.1016/j.carrev.2025.03.024
citation_public_url	https://hdl.handle.net/11094/103888

Comparison of drug-coated versus conventional balloons for the side branch of the bifurcation lesion - multicenter randomized controlled study - (OCVC-BIF): Design and rationale

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