Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children

Suehiro, Yuto; Okuda, Makoto; Otsugu, Masatoshi; Ochiai, Marin; Takagi, Misato; Tojo, Fumikazu; Mikasa, Yusuke; Naka, Shuhei; Matsumoto-Nakano, Michiyo; Lapirattanakul, Jinthana; Okawa, Rena; Nomura, Ryota; Nakano, Kazuhiko

doi:https://doi.org/10.1038/s41598-025-11478-w

Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children

Suehiro, Yuto; Okuda, Makoto; Otsugu, Masatoshi et al.

Scientific Reports, 2025, 15, 27047

Number of Access:13（2026-04-03 20:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/104043

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Title	Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children
Creator	CreatorName Suehiro, Yuto
	CreatorName Okuda, Makoto
	NRID 1000040803086 1000040803086 researchmap permalink tsugu tsugu Scopus Author ID 55853966200 55853966200 CreatorName Otsugu, Masatoshi
	CreatorName Ochiai, Marin
	CreatorName Takagi, Misato
	CreatorName Tojo, Fumikazu
	ORCID 0009-0000-1538-0745 0009-0000-1538-0745 Scopus Author ID 57851237900 57851237900 CreatorName Mikasa, Yusuke
	NRID 1000010589774 1000010589774 CreatorName Naka, Shuhei
	NRID 1000030359848 1000030359848 CreatorName Matsumoto-Nakano, Michiyo
	CreatorName Lapirattanakul, Jinthana
	NRID 1000080437384 1000080437384 ORCID 0000-0002-8634-209X 0000-0002-8634-209X researchmap permalink read0091517 read0091517 Scopus Author ID 9744705500 9744705500 CreatorName Okawa, Rena
	NRID 1000090437385 1000090437385 CreatorName Nomura, Ryota
	NRID 1000000379083 1000000379083 researchmap permalink read0202427 read0202427 Scopus Author ID 7402011667 7402011667 CreatorName Nakano, Kazuhiko
Subject	Cnm
	Collagen-binding protein
	Dental caries
	Japanese population
	Prevalence
	Streptococcus mutans
Description	Suehiro Y., Okuda M., Otsugu M., et al. Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children. Scientific Reports 15, 27047 (2025); https://doi.org/10.1038/s41598-025-11478-w.
Abstract	Dental caries is a highly prevalent infectious disease primarily caused by the pathogenic bacterium Streptococcus mutans, which has also been associated with systemic disease. A 120-kDa collagen-binding protein (Cnm) produced by S. mutans contributes to cardiovascular disease pathogenicity. Few studies have addressed the current prevalence of S. mutans and the cnm gene in Japanese children or examined caries pathology in relation to cnm presence. Here, we investigated the prevalence of S. mutans and the distribution of cnm-positive S. mutans among 490 children who visited two university hospitals in Japan. The caries experience index (dmft/DMFT) was calculated, and the collagen-binding ability of cnm-positive S. mutans strains was assessed. S. mutans was isolated from the oral cavities of 158 patients (36.8%); 10.1% (16/158) harbored cnm-positive S. mutans. When caries experience indices were compared across dentitions, patients harboring cnm-positive strains had significantly higher dmft/DMFT scores than those with cnm-negative strains (P < 0.05). Additionally, a positive correlation was observed between the collagen-binding capacity of cnm-positive S. mutans and the dmft/DMFT score (r = 0.601, P < 0.05). These findings suggest that cnm contributes to caries progression through collagen-mediated adherence to tooth surfaces. The presence of cnm-positive S. mutans may represent a risk factor for increased caries susceptibility in children.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	15
Page	27047
Date of Issued	2025-07-25
Language	English
Handle URL	https://hdl.handle.net/11094/104043
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-025-11478-w
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15, p. 27047
DC.title	Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children
DC.creator	Suehiro, Yuto
	Okuda, Makoto
	Otsugu, Masatoshi
	Ochiai, Marin
	Takagi, Misato
	Tojo, Fumikazu
	Mikasa, Yusuke
	Naka, Shuhei
	Matsumoto-Nakano, Michiyo
	Lapirattanakul, Jinthana
	Okawa, Rena
	Nomura, Ryota
	Nakano, Kazuhiko
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-25
DC.identifier	https://doi.org/10.1038/s41598-025-11478-w
DC.subject	Cnm
	Collagen-binding protein
	Dental caries
	Japanese population
	Prevalence
	Streptococcus mutans
DC.description	Suehiro Y., Okuda M., Otsugu M., et al. Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children. Scientific Reports 15, 27047 (2025); https://doi.org/10.1038/s41598-025-11478-w.
DCTERMS.abstract	Dental caries is a highly prevalent infectious disease primarily caused by the pathogenic bacterium Streptococcus mutans, which has also been associated with systemic disease. A 120-kDa collagen-binding protein (Cnm) produced by S. mutans contributes to cardiovascular disease pathogenicity. Few studies have addressed the current prevalence of S. mutans and the cnm gene in Japanese children or examined caries pathology in relation to cnm presence. Here, we investigated the prevalence of S. mutans and the distribution of cnm-positive S. mutans among 490 children who visited two university hospitals in Japan. The caries experience index (dmft/DMFT) was calculated, and the collagen-binding ability of cnm-positive S. mutans strains was assessed. S. mutans was isolated from the oral cavities of 158 patients (36.8%); 10.1% (16/158) harbored cnm-positive S. mutans. When caries experience indices were compared across dentitions, patients harboring cnm-positive strains had significantly higher dmft/DMFT scores than those with cnm-negative strains (P < 0.05). Additionally, a positive correlation was observed between the collagen-binding capacity of cnm-positive S. mutans and the dmft/DMFT score (r = 0.601, P < 0.05). These findings suggest that cnm contributes to caries progression through collagen-mediated adherence to tooth surfaces. The presence of cnm-positive S. mutans may represent a risk factor for increased caries susceptibility in children.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	104043
citation_title	Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children
citation_author	Suehiro, Yuto
	Okuda, Makoto
	Otsugu, Masatoshi
	Ochiai, Marin
	Takagi, Misato
	Tojo, Fumikazu
	Mikasa, Yusuke
	Naka, Shuhei
	Matsumoto-Nakano, Michiyo
	Lapirattanakul, Jinthana
	Okawa, Rena
	Nomura, Ryota
	Nakano, Kazuhiko
citation_publisher	Nature Research
citation_language	English
citation_date	2025-07-25
citation_journal_title	Scientific Reports
citation_volume	15
citation_firstpage	27047
citation_doi	https://doi.org/10.1038/s41598-025-11478-w
citation_public_url	https://hdl.handle.net/11094/104043

Prevalence of Streptococcus mutans harboring the cnm gene encoding cell surface protein Cnm in Japanese children

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