Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma

Kawashima, Rumi; Matsushita, Kenji; Kurashige, Masako et al.

Japanese Journal of Ophthalmology, 2026

Number of Access:12（2026-06-01 04:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/104807

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Title
Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma
Creator
NRID
1000000843616 1000000843616
researchmap permalink
kawashimarunrun kawashimarunrun
Scopus Author ID
56689448300 56689448300
CreatorName
Kawashima, Rumi
NRID
1000040437405 1000040437405
ORCID
0000-0002-0418-6696 0000-0002-0418-6696
researchmap permalink
let-there-be-light let-there-be-light
Scopus Author ID
55738831600 55738831600
CreatorName
Matsushita, Kenji
NRID
1000010836422 1000010836422
researchmap permalink
gerbil gerbil
CreatorName
Kurashige, Masako
NRID
1000050747037 1000050747037
ORCID
0000-0002-6753-1688 0000-0002-6753-1688
researchmap permalink
takahiromatsui takahiromatsui
Scopus Author ID
35176152500 35176152500
CreatorName
Matsui, Takahiro
NRID
1000060948074 1000060948074
researchmap permalink
y_motoyama y_motoyama
Scopus Author ID
57208337832 57208337832
CreatorName
Motoyama, Yuichi
NRID
1000080565052 1000080565052
CreatorName
Fujino, Takahiro
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiichi
NRID
1000040244610 1000040244610
ORCID
0000-0001-9069-3610 0000-0001-9069-3610
researchmap permalink
read0131487 read0131487
Scopus Author ID
57211973404 57211973404
CreatorName
Nishida, Kohji
Subject
Baerveldt glaucoma implant
Childhood glaucoma
Fibrosis
Refractory glaucoma
Description
Kawashima R., Matsushita K., Kurashige M., et al. Fibrotic response after Baerveldt glaucoma drainage device surgery: an initial sight-threatening sign in eyes with refractory childhood glaucoma. Japanese Journal of Ophthalmology (2026); https://doi.org/10.1007/s10384-026-01357-w.
Abstract
Purpose: We report the pathological analysis of a postoperative fibrotic reaction as an initial sign of a sight-threatening complication observed during the 2-year outcomes follow up of Baerveldt glaucoma implant (BGI) surgery in eyes with refractory childhood glaucoma. Study design: Retrospective case series. Methods: Fifteen eyes of 10 patients with refractory childhood glaucoma underwent BGI surgery between 2013 and 2020 at the University of Osaka Hospital. Patients were followed for a minimum of 2 years postoperatively. We investigated the postoperative complications, and histopathologically analyzed the specimens obtained from three eyes with postoperative fibrous membranes on the irises. Results: Nine eyes (60%) had a postoperative fibrous membrane around the tube or on the iris close to the tube, whereas two eyes developed a tractional retinal detachment. The pathological results indicated the tissues were eosinophilic fibrous scar tissues that did not have inflammatory or neoplastic lesions. Conclusion: BGI surgery was effective in patients with refractory childhood glaucoma. However, clinicians should be alert to the potential for development of fibrotic ocular inflammation in refractory childhood glaucoma eyes.
Publisher
Springer
Source Title
Japanese Journal of Ophthalmology
Date of Issued
2026-05-02
Language
English
Handle URL
https://hdl.handle.net/11094/104807
PISSN
00215155
eISSN
16132246
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s10384-026-01357-w
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article