A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity

Matsuzaka, Tadaaki; Matsugaki, Aira; Nakano, Takayoshi

Biomaterials, 2026, 331, 124101

Number of Access:1（2026-05-27 05:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/104833

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Title
A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity
Creator
NRID
1000001019109 1000001019109
ORCID
0000-0002-6215-2873 0000-0002-6215-2873
researchmap permalink
tadaaki_matsuzaka tadaaki_matsuzaka
Scopus Author ID
57218552928 57218552928
CreatorName
Matsuzaka, Tadaaki
NRID
1000010592529 1000010592529
ORCID
0000-0002-8427-7124 0000-0002-8427-7124
researchmap permalink
aira aira
Scopus Author ID
24172720900 24172720900
CreatorName
Matsugaki, Aira
NRID
1000030243182 1000030243182
ORCID
0000-0001-8052-1698 0000-0001-8052-1698
researchmap permalink
read0013987 read0013987
Scopus Author ID
7403896013 7403896013
CreatorName
Nakano, Takayoshi
Subject
Biomedical alloys design
Corrosion behavior
In vitrocytocompatibility
Metal ion toxicity
Osteoblast response
VITA Index (Velocity–Ion Toxicity–Affinity)
Description
Matsuzaka T., Matsugaki A., Nakano T.. A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity. Biomaterials 331, 124101 (2026); https://doi.org/10.1016/j.biomaterials.2026.124101.
Abstract
Biocompatibility and cytocompatibility are critical early considerations in the development of metallic biomaterials for implantable devices; however, conventional in vitro cytotoxicity evaluations typically assess corrosion behavior or cytotoxicity independently and fail to account for their coupled effects on metal-ion release–driven cytocompatibility. Here, we present a novel Velocity–Ion Toxicity–Affinity (VITA) Index—a quantitative and mechanistically informed framework that integrates electrochemical dissolution (corrosion) behavior with ion-specific cytotoxicity to evaluate in vitro biocompatibility governed by metal-ion release. By combining corrosion profiling with cell-based cytocompatibility assays (using osteoblasts and fibroblasts as a representative model), the VITA Index demonstrates first-order accuracy, capturing robust correlations between ion-release kinetics and cell viability across both established biomedical alloys and emerging materials, including high-entropy alloys. The VITA Index enables rapid and mechanistically informed screening of candidate metallic biomaterials and provides a practical framework for in vitro biocompatibility assessment, cytotoxicity prediction, and data-driven alloy design for future implant applications.
Publisher
Elsevier Ltd
Source Title
Biomaterials
Volume (Issue)
331
Page
124101
Date of Issued
2026-03-14
Language
English
Handle URL
https://hdl.handle.net/11094/104833
PISSN
01429612
eISSN
18785905
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.biomaterials.2026.124101
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article