Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking

Sekiya, Ryo; Nakamoto, Masahiko; Kato, Shunsuke; Hayashi, Takashi; Matsusaki, Michiya

doi:https://doi.org/10.1016/j.jconrel.2026.114867

Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking

Sekiya, Ryo; Nakamoto, Masahiko; Kato, Shunsuke et al.

Journal of Controlled Release, 2026, 394, 114867

Number of Access:6（2026-06-02 04:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/104844

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Title	Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking
Creator	CreatorName Sekiya, Ryo
	NRID 1000030883003 1000030883003 ORCID 0000-0003-4570-5429 0000-0003-4570-5429 researchmap permalink m-nakamoto m-nakamoto Scopus Author ID 55363093100 55363093100 CreatorName Nakamoto, Masahiko
	NRID 1000060909125 1000060909125 ORCID 0009-0003-6824-612X 0009-0003-6824-612X researchmap permalink s_kato_chem s_kato_chem Scopus Author ID 57195564115 57195564115 CreatorName Kato, Shunsuke
	NRID 1000020222226 1000020222226 ORCID 0000-0002-2215-935X 0000-0002-2215-935X researchmap permalink 20190602_Sun 20190602_Sun Scopus Author ID 55735983400 55735983400 CreatorName Hayashi, Takashi
	NRID 1000000419467 1000000419467 ORCID 0000-0003-4294-9313 0000-0003-4294-9313 researchmap permalink read0093431 read0093431 Scopus Author ID 6701561701 6701561701 CreatorName Matsusaki, Michiya
Description	Sekiya R., Nakamoto M., Kato S., et al. Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking. Journal of Controlled Release 394, 114867 (2026); https://doi.org/10.1016/j.jconrel.2026.114867.
Abstract	We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity ligand, while enzymatic degradation of the phosphate ester triggers the sol transition pathway. The transition from the gel to the sol state was driven by the dissipation of a transient thermodynamic state under out-of-equilibrium conditions. The transient gel persisted because of the kinetic imbalance between fast gelation and the slow sol transition pathway. By tuning the kinetic balance of these pathways, the lifetime of the transient hydrogel was programmed over a wide range—from within an hour to three months. Additionally, the ability of the hydrogel to control the payload release induced by sol transition was validated. The unique properties of the present system are expected to have applications in drug delivery systems tailored to patient needs and objectives, as well as in scaffold materials for tissue engineering.
Publisher	Elsevier B.V.
Source Title	Journal of Controlled Release
Volume (Issue)	394
Page	114867
Date of Issued	2026-03-28
Language	English
Handle URL	https://hdl.handle.net/11094/104844
PISSN	01683659
eISSN	18734995
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.jconrel.2026.114867
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Controlled Release. 2026, 394, p. 114867
DC.title	Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking
DC.creator	Sekiya, Ryo
	Nakamoto, Masahiko
	Kato, Shunsuke
	Hayashi, Takashi
	Matsusaki, Michiya
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-03-28
DC.identifier	https://doi.org/10.1016/j.jconrel.2026.114867
DC.description	Sekiya R., Nakamoto M., Kato S., et al. Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking. Journal of Controlled Release 394, 114867 (2026); https://doi.org/10.1016/j.jconrel.2026.114867.
DCTERMS.abstract	We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity ligand, while enzymatic degradation of the phosphate ester triggers the sol transition pathway. The transition from the gel to the sol state was driven by the dissipation of a transient thermodynamic state under out-of-equilibrium conditions. The transient gel persisted because of the kinetic imbalance between fast gelation and the slow sol transition pathway. By tuning the kinetic balance of these pathways, the lifetime of the transient hydrogel was programmed over a wide range—from within an hour to three months. Additionally, the ability of the hydrogel to control the payload release induced by sol transition was validated. The unique properties of the present system are expected to have applications in drug delivery systems tailored to patient needs and objectives, as well as in scaffold materials for tissue engineering.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	104844
citation_title	Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking
citation_author	Sekiya, Ryo
	Nakamoto, Masahiko
	Kato, Shunsuke
	Hayashi, Takashi
	Matsusaki, Michiya
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2026-03-28
citation_journal_title	Journal of Controlled Release
citation_volume	394
citation_firstpage	114867
citation_doi	https://doi.org/10.1016/j.jconrel.2026.114867
citation_public_url	https://hdl.handle.net/11094/104844

Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking

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