Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer

Tani, Masaru; Hatano, Koji; Kamiya, Takashi; Konishi, Masatoshi; Matsukawa, Atsuki; Horitani, Hiromu; Inoguchi, Syunsuke; Kanaki, Tomohiro; Yoshimura, Akihiro; Horibe, Yuki; Liu, Yutong; Sassi, Nesrine; Oka, Toshiki; Okuda, Yohei; Yamamichi, Gaku; Ishizuya, Yu; Hayashi, Takuji; Yamamoto, Yoshiyuki; Kato, Taigo; Watabe, Tadashi; Kawashima, Atsunari; Isohashi, Kayako; Nonomura, Norio

doi:https://doi.org/10.1002/bco2.70212

Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer

Tani, Masaru; Hatano, Koji; Kamiya, Takashi et al.

BJUI Compass, 2026, 7(5), e70212

Number of Access:95（2026-07-28 07:08 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/105131

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Title	Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer
Creator	NRID 1000090981960 1000090981960 CreatorName Tani, Masaru
	NRID 1000060762234 1000060762234 ORCID 0000-0002-8409-5152 0000-0002-8409-5152 researchmap permalink koji_hatano koji_hatano Scopus Author ID 14627167600 14627167600 CreatorName Hatano, Koji
	NRID 1000080550764 1000080550764 ORCID 0000-0002-6699-8796 0000-0002-6699-8796 Scopus Author ID 57202820345 57202820345 CreatorName Kamiya, Takashi
	NRID 1000091022599 1000091022599 Scopus Author ID 57640041800 57640041800 CreatorName Konishi, Masatoshi
	NRID 1000091022672 1000091022672 Scopus Author ID 57678508100 57678508100 CreatorName Matsukawa, Atsuki
	NRID 1000031022634 1000031022634 ORCID 0009-0007-7413-0755 0009-0007-7413-0755 Scopus Author ID 57211639645 57211639645 CreatorName Horitani, Hiromu
	CreatorName Inoguchi, Syunsuke
	NRID 1000091001460 1000091001460 Scopus Author ID 57211646513 57211646513 CreatorName Kanaki, Tomohiro
	NRID 1000070981992 1000070981992 CreatorName Yoshimura, Akihiro
	NRID 1000080981977 1000080981977 CreatorName Horibe, Yuki
	CreatorName Liu, Yutong
	CreatorName Sassi, Nesrine
	NRID 1000060964385 1000060964385 Scopus Author ID 57202192870 57202192870 CreatorName Oka, Toshiki
	NRID 1000010964372 1000010964372 ORCID 0000-0001-9909-4200 0000-0001-9909-4200 researchmap permalink okudayohei okudayohei Scopus Author ID 57200321452 57200321452 CreatorName Okuda, Yohei
	NRID 1000040882262 1000040882262 ORCID 0000-0003-2262-8141 0000-0003-2262-8141 researchmap permalink urology-osaka-japan urology-osaka-japan Scopus Author ID 56983033900 56983033900 CreatorName Yamamichi, Gaku
	NRID 1000000783854 1000000783854 ORCID 0000-0003-0778-1308 0000-0003-0778-1308 researchmap permalink okiishi okiishi Scopus Author ID 56509501000 56509501000 CreatorName Ishizuya, Yu
	NRID 1000050747079 1000050747079 researchmap permalink takuhaya takuhaya Scopus Author ID 7406384458 7406384458 CreatorName Hayashi, Takuji
	NRID 1000090759557 1000090759557 ORCID 0000-0002-1271-3521 0000-0002-1271-3521 researchmap permalink yoshi229 yoshi229 Scopus Author ID 13404872700 13404872700 CreatorName Yamamoto, Yoshiyuki
	NRID 1000070648021 1000070648021 ORCID 0000-0002-8681-1407 0000-0002-8681-1407 researchmap permalink taigokato taigokato Scopus Author ID 55414697500 55414697500 CreatorName Kato, Taigo
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 CreatorName Watabe, Tadashi
	NRID 1000050746568 1000050746568 ORCID 0000-0001-9369-4264 0000-0001-9369-4264 researchmap permalink akawashima akawashima Scopus Author ID 9846139400 9846139400 CreatorName Kawashima, Atsunari
	NRID 1000050598604 1000050598604 ORCID 0000-0002-2081-3020 0000-0002-2081-3020 researchmap permalink researchmap5849 researchmap5849 Scopus Author ID 6505990065 6505990065 CreatorName Isohashi, Kayako
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 CreatorName Nonomura, Norio
Subject	bone metastases
	bone scan index
	bone scintigraphy
	bone-modifying agent
	denosumab
	mandible
	maxilla
	medication-related osteonecrosis of the jaw
	prostate cancer
	zoledronic acid
Description	Tani M., Hatano K., Kamiya T., et al. Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer. BJUI Compass 7, e70212 (2026); https://doi.org/10.1002/bco2.70212.
Abstract	Objective: This study aimed to evaluate the maximum bone scan index in the jaw (BSIJmax) before the development of clinical medication-related osteonecrosis of the jaw (MRONJ) in patients with prostate cancer. Methods: We retrospectively analysed 135 patients with prostate cancer and bone metastases who received bone-modifying agents (BMAs) between 2008 and 2025. Bone scintigraphy data were collected at baseline and during the BMA treatment. BSIJmax was calculated using computer-assisted diagnostic software (BONENAVI). Primary endpoints were BSIJmax in the maxilla and mandible before the clinical diagnosis of MRONJ, compared with baseline values. Secondary endpoints included area under the receiver operating characteristic curves (AUCs) for diagnosing MRONJ using BSIJmax in the maxilla and mandible. Results: Among 135 patients, 27 developed MRONJ during a median follow-up of 74 months (interquartile range, 41–124 months). Mandibular BSIJmax values before the clinical diagnosis of MRONJ were significantly higher than baseline values (0.090 vs. 0.027, p < 0.001), whereas maxillary values showed no significant change. The AUC for mandibular BSIJmax in diagnosing MRONJ was 0.803. A mandibular BSIJmax cut-off of 0.033 yielded a sensitivity and specificity of 85% and 71%, respectively, for the diagnosis of MRONJ. Conclusion: The mandibular BSIJmax increased before the clinical diagnosis of MRONJ. The incorporation of BSIJmax into bone scintigraphy may enable early detection of MRONJ and timely intervention in patients with prostate cancer receiving BMA therapy.
Publisher	John Wiley and Sons Inc
Source Title	BJUI Compass
Volume (Issue)	7(5)
Page	e70212
Date of Issued	2026-04-28
Language	English
Handle URL	https://hdl.handle.net/11094/105131
eISSN	26884526
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/bco2.70212
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	BJUI Compass. 2026, 7(5), p. e70212
DC.title	Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer
DC.creator	Tani, Masaru
	Hatano, Koji
	Kamiya, Takashi
	Konishi, Masatoshi
	Matsukawa, Atsuki
	Horitani, Hiromu
	Inoguchi, Syunsuke
	Kanaki, Tomohiro
	Yoshimura, Akihiro
	Horibe, Yuki
	Liu, Yutong
	Sassi, Nesrine
	Oka, Toshiki
	Okuda, Yohei
	Yamamichi, Gaku
	Ishizuya, Yu
	Hayashi, Takuji
	Yamamoto, Yoshiyuki
	Kato, Taigo
	Watabe, Tadashi
	Kawashima, Atsunari
	Isohashi, Kayako
	Nonomura, Norio
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-04-28
DC.identifier	https://doi.org/10.1002/bco2.70212
DC.subject	bone metastases
	bone scan index
	bone scintigraphy
	bone-modifying agent
	denosumab
	mandible
	maxilla
	medication-related osteonecrosis of the jaw
	prostate cancer
	zoledronic acid
DC.description	Tani M., Hatano K., Kamiya T., et al. Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer. BJUI Compass 7, e70212 (2026); https://doi.org/10.1002/bco2.70212.
DCTERMS.abstract	Objective: This study aimed to evaluate the maximum bone scan index in the jaw (BSIJmax) before the development of clinical medication-related osteonecrosis of the jaw (MRONJ) in patients with prostate cancer. Methods: We retrospectively analysed 135 patients with prostate cancer and bone metastases who received bone-modifying agents (BMAs) between 2008 and 2025. Bone scintigraphy data were collected at baseline and during the BMA treatment. BSIJmax was calculated using computer-assisted diagnostic software (BONENAVI). Primary endpoints were BSIJmax in the maxilla and mandible before the clinical diagnosis of MRONJ, compared with baseline values. Secondary endpoints included area under the receiver operating characteristic curves (AUCs) for diagnosing MRONJ using BSIJmax in the maxilla and mandible. Results: Among 135 patients, 27 developed MRONJ during a median follow-up of 74 months (interquartile range, 41–124 months). Mandibular BSIJmax values before the clinical diagnosis of MRONJ were significantly higher than baseline values (0.090 vs. 0.027, p < 0.001), whereas maxillary values showed no significant change. The AUC for mandibular BSIJmax in diagnosing MRONJ was 0.803. A mandibular BSIJmax cut-off of 0.033 yielded a sensitivity and specificity of 85% and 71%, respectively, for the diagnosis of MRONJ. Conclusion: The mandibular BSIJmax increased before the clinical diagnosis of MRONJ. The incorporation of BSIJmax into bone scintigraphy may enable early detection of MRONJ and timely intervention in patients with prostate cancer receiving BMA therapy.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	105131
citation_title	Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer
citation_author	Tani, Masaru
	Hatano, Koji
	Kamiya, Takashi
	Konishi, Masatoshi
	Matsukawa, Atsuki
	Horitani, Hiromu
	Inoguchi, Syunsuke
	Kanaki, Tomohiro
	Yoshimura, Akihiro
	Horibe, Yuki
	Liu, Yutong
	Sassi, Nesrine
	Oka, Toshiki
	Okuda, Yohei
	Yamamichi, Gaku
	Ishizuya, Yu
	Hayashi, Takuji
	Yamamoto, Yoshiyuki
	Kato, Taigo
	Watabe, Tadashi
	Kawashima, Atsunari
	Isohashi, Kayako
	Nonomura, Norio
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2026-04-28
citation_journal_title	BJUI Compass
citation_volume	7
citation_issue	5
citation_firstpage	e70212
citation_doi	https://doi.org/10.1002/bco2.70212
citation_public_url	https://hdl.handle.net/11094/105131

Bone scan index rise prior to osteonecrosis of the jaw with bone-modifying agents in prostate cancer

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