TACI is required for the survival of short- and long-lived plasma cells

Funakoshi, Kenji; Koike, Takuya; Ise, Wataru; Tai, Yuki; Narazaki, Masashi; Kumanogoh, Atsushi; Inoue, Takeshi; Kurosaki, Tomohiro

doi:https://doi.org/10.1093/intimm/dxaf067

TACI is required for the survival of short- and long-lived plasma cells

Funakoshi, Kenji; Koike, Takuya; Ise, Wataru et al.

International Immunology, 2025, 38(3), 197-206

Number of Access:8（2026-07-22 14:09 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/105211

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Title	TACI is required for the survival of short- and long-lived plasma cells
Creator	ORCID 0000-0002-1757-6925 0000-0002-1757-6925 researchmap permalink k-funakoshi k-funakoshi CreatorName Funakoshi, Kenji
	NRID 1000010855456 1000010855456 CreatorName Koike, Takuya
	NRID 1000070323483 1000070323483 researchmap permalink wataruise wataruise Scopus Author ID 6602103314 6602103314 CreatorName Ise, Wataru
	NRID 1000060985000 1000060985000 ORCID 0009-0007-7554-8512 0009-0007-7554-8512 researchmap permalink ytai ytai CreatorName Tai, Yuki
	NRID 1000000467573 1000000467573 ORCID 0000-0002-5613-4409 0000-0002-5613-4409 researchmap permalink mnarazaki mnarazaki Scopus Author ID 7004556201 7004556201 CreatorName Narazaki, Masashi
	NRID 1000010294125 1000010294125 ORCID 0000-0003-4749-7117 0000-0003-4749-7117 researchmap permalink read0051725 read0051725 Scopus Author ID 6602726311 6602726311 CreatorName Kumanogoh, Atsushi
	NRID 1000080466838 1000080466838 CreatorName Inoue, Takeshi
	NRID 1000050178125 1000050178125 ORCID 0000-0002-6352-304X 0000-0002-6352-304X researchmap permalink kurosakitomohiro kurosakitomohiro Scopus Author ID 7102059533 7102059533 CreatorName Kurosaki, Tomohiro
Subject	B cells
	BCMA
	Plasma cells
	TACI
Description	This is a pre-copyedited, author-produced version of an article accepted for publication in Immunology following following peer review. The version of record Funakoshi K., Koike T., Ise W., et al. TACI is required for the survival of short- and long-lived plasma cells. International Immunology 38, 197 (2026) is available online at: https://doi.org/10.1093/intimm/dxaf067.
Abstract	In a typical immune response, naïve B cells are activated, differentiated into short-lived plasma cells (SLPCs), and then matured into long-lived plasma cells (LLPCs) in the bone marrow. Among three TNF family receptors (BAFF-R, TACI, and BCMA), BAFF-R and BCMA are known to be crucial for the maintenance of naïve B cells and bone marrow LLPCs, respectively. In contrast, the function of TACI remains unclear, as analysis of global TACI knockout mice suggests the existence of two opposing roles in B and plasma cells. Here, to define the role of TACI during T cell-dependent (TD) immune responses in a B and plasma cell-intrinsic manner, we utilized adoptive transfer experiments employing B cells with a conditional TACI knockout. We show that B cell activation is apparently normal in the absence of TACI, while it is crucial for the expansion of IgM+ and IgG1+ SLPCs and maintenance of their resultant bone marrow LLPCs. Hence, our data suggest that the hyper-B cell activation seen in global TACI knockout mice could be due to an indirect control of BAFF levels or B cell extrinsic anomalies.
Publisher	Oxford University Press
Source Title	International Immunology
Volume (Issue)	38(3)
Page	197-206
Date of Issued	2025-11-11
Language	English
Handle URL	https://hdl.handle.net/11094/105211
PISSN	09538178
eISSN	14602377
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1093/intimm/dxaf067
Access Rights	embargoed access
CopyRight	The full-text file will be made open to the public on 11 November 2026 in accordance with the publisher's policy.
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article
Category	学術雑誌論文付属データあり Journal Article with associated Data

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	International Immunology. 2025, 38(3), p. 197-206
DC.title	TACI is required for the survival of short- and long-lived plasma cells
DC.creator	Funakoshi, Kenji
	Koike, Takuya
	Ise, Wataru
	Tai, Yuki
	Narazaki, Masashi
	Kumanogoh, Atsushi
	Inoue, Takeshi
	Kurosaki, Tomohiro
DC.publisher	Oxford University Press
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-11-11
DC.identifier	https://doi.org/10.1093/intimm/dxaf067
DC.subject	B cells
	BCMA
	Plasma cells
	TACI
DC.description	This is a pre-copyedited, author-produced version of an article accepted for publication in Immunology following following peer review. The version of record Funakoshi K., Koike T., Ise W., et al. TACI is required for the survival of short- and long-lived plasma cells. International Immunology 38, 197 (2026) is available online at: https://doi.org/10.1093/intimm/dxaf067.
DCTERMS.abstract	In a typical immune response, naïve B cells are activated, differentiated into short-lived plasma cells (SLPCs), and then matured into long-lived plasma cells (LLPCs) in the bone marrow. Among three TNF family receptors (BAFF-R, TACI, and BCMA), BAFF-R and BCMA are known to be crucial for the maintenance of naïve B cells and bone marrow LLPCs, respectively. In contrast, the function of TACI remains unclear, as analysis of global TACI knockout mice suggests the existence of two opposing roles in B and plasma cells. Here, to define the role of TACI during T cell-dependent (TD) immune responses in a B and plasma cell-intrinsic manner, we utilized adoptive transfer experiments employing B cells with a conditional TACI knockout. We show that B cell activation is apparently normal in the absence of TACI, while it is crucial for the expansion of IgM+ and IgG1+ SLPCs and maintenance of their resultant bone marrow LLPCs. Hence, our data suggest that the hyper-B cell activation seen in global TACI knockout mice could be due to an indirect control of BAFF levels or B cell extrinsic anomalies.
DC.rights	The full-text file will be made open to the public on 11 November 2026 in accordance with the publisher's policy.
DC.format	105211
citation_title	TACI is required for the survival of short- and long-lived plasma cells
citation_author	Funakoshi, Kenji
	Koike, Takuya
	Ise, Wataru
	Tai, Yuki
	Narazaki, Masashi
	Kumanogoh, Atsushi
	Inoue, Takeshi
	Kurosaki, Tomohiro
citation_publisher	Oxford University Press
citation_language	English
citation_date	2025-11-11
citation_journal_title	International Immunology
citation_volume	38
citation_issue	3
citation_firstpage	197
citation_lastpage	206
citation_doi	https://doi.org/10.1093/intimm/dxaf067
citation_public_url	https://hdl.handle.net/11094/105211

TACI is required for the survival of short- and long-lived plasma cells

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