Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

Liu, Yuwei; Hatano, Koji; Uemura, Motohide; Hirata, Takero; Naka, Sadahiro; Kurimoto, Kenta; Sasaki, Hidetaka; Kamiya, Takashi; Aihara, Ryo; Ding, Feier; Cardinale, Jens; Giesel, Frederik L.; Werner, Rudolf A.; Katayama, Daisuke; Kato, Hiroki; Isohashi, Kayako; Tomiyama, Noriyuki; Nonomura, Norio; Watabe, Tadashi

doi:https://doi.org/10.1007/s00259-026-07931-1

Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

Liu, Yuwei; Hatano, Koji; Uemura, Motohide et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2026

Number of Access:545（2026-09-29 08:33 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/105900

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
EurJNuclMedMolImaging_2026	pdf	None	1.86 MB	29	2026.07.30

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
Creator	ORCID 0000-0003-0762-9840 0000-0003-0762-9840 Scopus Author ID 57209179470 57209179470 CreatorName Liu, Yuwei
	NRID 1000060762234 1000060762234 ORCID 0000-0002-8409-5152 0000-0002-8409-5152 researchmap permalink koji_hatano koji_hatano Scopus Author ID 14627167600 14627167600 CreatorName Hatano, Koji
	NRID 1000040631015 1000040631015 researchmap permalink urourouro urourouro CreatorName Uemura, Motohide
	NRID 1000020777916 1000020777916 researchmap permalink HirataTakero HirataTakero Scopus Author ID 56485165100 56485165100 CreatorName Hirata, Takero
	NRID 1000060599843 1000060599843 researchmap permalink _sada_ _sada_ CreatorName Naka, Sadahiro
	NRID 1000070868968 1000070868968 researchmap permalink kentakuri kentakuri Scopus Author ID 57223821707 57223821707 CreatorName Kurimoto, Kenta
	NRID 1000010738628 1000010738628 ORCID 0009-0003-6630-3784 0009-0003-6630-3784 CreatorName Sasaki, Hidetaka
	NRID 1000080550764 1000080550764 ORCID 0000-0002-6699-8796 0000-0002-6699-8796 Scopus Author ID 57202820345 57202820345 CreatorName Kamiya, Takashi
	CreatorName Aihara, Ryo
	CreatorName Ding, Feier
	CreatorName Cardinale, Jens
	CreatorName Giesel, Frederik L.
	CreatorName Werner, Rudolf A.
	researchmap permalink daisuke_katayama daisuke_katayama CreatorName Katayama, Daisuke
	NRID 1000020448054 1000020448054 ORCID 0000-0003-0838-6772 0000-0003-0838-6772 researchmap permalink kato-h kato-h Scopus Author ID 55585587900 55585587900 CreatorName Kato, Hiroki
	NRID 1000050598604 1000050598604 ORCID 0000-0002-2081-3020 0000-0002-2081-3020 researchmap permalink researchmap5849 researchmap5849 Scopus Author ID 6505990065 6505990065 CreatorName Isohashi, Kayako
	NRID 1000050294070 1000050294070 ORCID 0000-0001-9918-7327 0000-0001-9918-7327 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 CreatorName Nonomura, Norio
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 CreatorName Watabe, Tadashi
Subject	PET/CT
	Positivity threshold
	Prostate cancer
	PSMA-RADS
	[¹⁸F]PSMA-1007
Description	Liu Y., Hatano K., Uemura M., et al. Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan. European Journal of Nuclear Medicine and Molecular Imaging (2026); https://doi.org/10.1007/s00259-026-07931-1.
Abstract	Purpose: The PSMA Reporting and Data System (PSMA-RADS) has been proposed to standardize the interpretation of PSMA-PET. However, its diagnostic performance has not been fully validated. This study aimed to determine the optimal interpretation criteria for PSMA-PET and to compare its diagnostic performance with conventional imaging. Methods: This prospective study enrolled 284 patients across various disease stages who underwent [¹⁸F]PSMA-1007 PET/CT. Diagnostic performance was evaluated using different positivity thresholds based on PSMA-RADS categories, PSMA-expression scores, and SUVmax, and was compared with that of CT and bone scan (BS). True-positive rates were summarized across PSMA-RADS categories. Results: A total of 771 lesions were analyzed. PSMA-RADS demonstrated superior diagnostic performance compared with other interpretation criteria. Using PSMA-RADS-4 as the positivity threshold, [¹⁸F]PSMA-1007 PET/CT achieved a sensitivity of 78.5% and a specificity of 95.3%. PSMA-RADS-3 increased sensitivity to 98.4% but reduced specificity to 58.8%. PSMA-expression score 2 yielded a sensitivity of 52.2% and a specificity of 99.3%, whereas SUVmax cutoff of 5.7 yielded a sensitivity of 72.6% and a specificity of 85.8%. When PSMA-RADS-4 was used as the positivity threshold, PET/CT showed higher sensitivity than CT (81.3% vs. 48.6%) and BS (84.5% vs. 65.7%), as well as higher accuracy (83.2% vs. 56.2% and 87.6% vs. 74.5%, respectively). The true-positive rate of PSMA-RADS-3 lesions was 69.7%, which was substantially lower than that of PSMA-RADS-4 lesions (96.7%). Conclusion: PSMA-RADS-4 represents an optimal positivity threshold for [¹⁸F]PSMA-1007 PET/CT, providing superior diagnostic performance compared with CT and BS and supporting its clinical utility for standardized image interpretation.
Publisher	Springer
Source Title	European Journal of Nuclear Medicine and Molecular Imaging
Date of Issued	2026-05-22
Language	English
Handle URL	https://hdl.handle.net/11094/105900
PISSN	16197070
eISSN	16197089
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00259-026-07931-1
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	European Journal of Nuclear Medicine and Molecular Imaging. 2026
DC.title	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
DC.creator	Liu, Yuwei
	Hatano, Koji
	Uemura, Motohide
	Hirata, Takero
	Naka, Sadahiro
	Kurimoto, Kenta
	Sasaki, Hidetaka
	Kamiya, Takashi
	Aihara, Ryo
	Ding, Feier
	Cardinale, Jens
	Giesel, Frederik L.
	Werner, Rudolf A.
	Katayama, Daisuke
	Kato, Hiroki
	Isohashi, Kayako
	Tomiyama, Noriyuki
	Nonomura, Norio
	Watabe, Tadashi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-05-22
DC.identifier	https://doi.org/10.1007/s00259-026-07931-1
DC.subject	PET/CT
	Positivity threshold
	Prostate cancer
	PSMA-RADS
	[¹⁸F]PSMA-1007
DC.description	Liu Y., Hatano K., Uemura M., et al. Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan. European Journal of Nuclear Medicine and Molecular Imaging (2026); https://doi.org/10.1007/s00259-026-07931-1.
DCTERMS.abstract	Purpose: The PSMA Reporting and Data System (PSMA-RADS) has been proposed to standardize the interpretation of PSMA-PET. However, its diagnostic performance has not been fully validated. This study aimed to determine the optimal interpretation criteria for PSMA-PET and to compare its diagnostic performance with conventional imaging. Methods: This prospective study enrolled 284 patients across various disease stages who underwent [¹⁸F]PSMA-1007 PET/CT. Diagnostic performance was evaluated using different positivity thresholds based on PSMA-RADS categories, PSMA-expression scores, and SUVmax, and was compared with that of CT and bone scan (BS). True-positive rates were summarized across PSMA-RADS categories. Results: A total of 771 lesions were analyzed. PSMA-RADS demonstrated superior diagnostic performance compared with other interpretation criteria. Using PSMA-RADS-4 as the positivity threshold, [¹⁸F]PSMA-1007 PET/CT achieved a sensitivity of 78.5% and a specificity of 95.3%. PSMA-RADS-3 increased sensitivity to 98.4% but reduced specificity to 58.8%. PSMA-expression score 2 yielded a sensitivity of 52.2% and a specificity of 99.3%, whereas SUVmax cutoff of 5.7 yielded a sensitivity of 72.6% and a specificity of 85.8%. When PSMA-RADS-4 was used as the positivity threshold, PET/CT showed higher sensitivity than CT (81.3% vs. 48.6%) and BS (84.5% vs. 65.7%), as well as higher accuracy (83.2% vs. 56.2% and 87.6% vs. 74.5%, respectively). The true-positive rate of PSMA-RADS-3 lesions was 69.7%, which was substantially lower than that of PSMA-RADS-4 lesions (96.7%). Conclusion: PSMA-RADS-4 represents an optimal positivity threshold for [¹⁸F]PSMA-1007 PET/CT, providing superior diagnostic performance compared with CT and BS and supporting its clinical utility for standardized image interpretation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	105900
citation_title	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
citation_author	Liu, Yuwei
	Hatano, Koji
	Uemura, Motohide
	Hirata, Takero
	Naka, Sadahiro
	Kurimoto, Kenta
	Sasaki, Hidetaka
	Kamiya, Takashi
	Aihara, Ryo
	Ding, Feier
	Cardinale, Jens
	Giesel, Frederik L.
	Werner, Rudolf A.
	Katayama, Daisuke
	Kato, Hiroki
	Isohashi, Kayako
	Tomiyama, Noriyuki
	Nonomura, Norio
	Watabe, Tadashi
citation_publisher	Springer
citation_language	English
citation_date	2026-05-22
citation_journal_title	European Journal of Nuclear Medicine and Molecular Imaging
citation_doi	https://doi.org/10.1007/s00259-026-07931-1
citation_public_url	https://hdl.handle.net/11094/105900

Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

Link to primary information

Item Information

Show details