Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System

Takei, Yosuke; Harada, Akihiro; Takeda, Sen; Kobayashi, Katsunori; Terada, Sumio; Noda, Tetsuo; Takahashi, Tomoyuki; Hirokawa, Nobutaka

doi:https://doi.org/10.1083/jcb.131.6.1789

Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System

Takei, Yosuke; Harada, Akihiro; Takeda, Sen et al.

Journal of Cell Biology, 1995, 131(6), 1789-1800

Number of Access:816（2025-07-27 23:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/23087

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Title	Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
Creator	NRID 1000020272487 1000020272487 CreatorName Takei, Yosuke
	NRID 1000040251441 1000040251441 researchmap permalink aharada aharada Scopus Author ID 7202253419 7202253419 CreatorName Harada, Akihiro
	NRID 1000020272429 1000020272429 CreatorName Takeda, Sen
	NRID 1000010322041 1000010322041 CreatorName Kobayashi, Katsunori
	NRID 1000000262022 1000000262022 CreatorName Terada, Sumio
	NRID 1000010183550 1000010183550 CreatorName Noda, Tetsuo
	NRID 1000040092415 1000040092415 CreatorName Takahashi, Tomoyuki
	NRID 1000020010085 1000020010085 CreatorName Hirokawa, Nobutaka
Abstract	Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synapsin I appeared to develop normally and did not have gross anatomical abnormalities. However, when we examined the presynaptic structure of the hippocampal CA3 field in detail, we found that the sizes of mossy fiber giant terminals were significantly smaller, the number of synaptic vesicles became reduced, and the presynaptic structures altered, although the mossy fiber long-term potentiation remained intact. These results suggest significant contribution of synapsin I to the formation and maintenance of the presynaptic structure.
Publisher	The Rockefeller University Press
Source Title	Journal of Cell Biology
Volume (Issue)	131(6)
Page	1789-1800
Date of Issued	1995-11-15
Language	English
Handle URL	https://hdl.handle.net/11094/23087
PISSN	00219525
NCID	AA00694812
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1083/jcb.131.6.1789
Access Rights	open access
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Cell Biology. 1995, 131(6), p. 1789-1800
DC.title	Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
DC.creator	Takei, Yosuke
	Harada, Akihiro
	Takeda, Sen
	Kobayashi, Katsunori
	Terada, Sumio
	Noda, Tetsuo
	Takahashi, Tomoyuki
	Hirokawa, Nobutaka
DC.publisher	The Rockefeller University Press
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	1995-11-15
DC.identifier	https://doi.org/10.1083/jcb.131.6.1789
DCTERMS.abstract	Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synapsin I appeared to develop normally and did not have gross anatomical abnormalities. However, when we examined the presynaptic structure of the hippocampal CA3 field in detail, we found that the sizes of mossy fiber giant terminals were significantly smaller, the number of synaptic vesicles became reduced, and the presynaptic structures altered, although the mossy fiber long-term potentiation remained intact. These results suggest significant contribution of synapsin I to the formation and maintenance of the presynaptic structure.
DC.format	23087
citation_title	Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
citation_author	Takei, Yosuke
	Harada, Akihiro
	Takeda, Sen
	Kobayashi, Katsunori
	Terada, Sumio
	Noda, Tetsuo
	Takahashi, Tomoyuki
	Hirokawa, Nobutaka
citation_publisher	The Rockefeller University Press
citation_language	English
citation_date	1995-11-15
citation_journal_title	Journal of Cell Biology
citation_volume	131
citation_issue	6
citation_firstpage	1789
citation_lastpage	1800
citation_doi	https://doi.org/10.1083/jcb.131.6.1789
citation_public_url	https://hdl.handle.net/11094/23087

Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System

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