電位依存性プロトンチャネルに見る膜電位センサーの謎 : 細胞膜中に存在する電荷

黒川, 竜紀; 岡村, 康司

生物物理, 2011, 51(2), 072-075

Number of Access:566（2025-07-18 09:56 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/23166

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
sb_51_2_072 pdf None 835 KB 389 2012.11.16  

Item Information

Output File Export EndNote Basic Export Mendeley

Title
電位依存性プロトンチャネルに見る膜電位センサーの謎 : 細胞膜中に存在する電荷
Mechanisms of Voltage Sensor Domain and Voltage-Gated Proton Channel
デンイ　イゾンセイ　プロトンチャネル　ニ　ミル　マクデンイ　センサー　ノ　ナゾ　サイボウマクチュウ　ニ　ソンザイスル　デンカ
Creator
NRID
1000040527701 1000040527701
CreatorName
黒川, 竜紀 ; クロカワ, タツキ ; Kurokawa, Tatsuki
NRID
1000080201987 1000080201987
researchmap permalink
yasushiokamura yasushiokamura
Scopus Author ID
55322083200 55322083200
ORCID
0000-0001-5386-7968 0000-0001-5386-7968
CreatorName
岡村, 康司 ; オカムラ, ヤスシ ; Okamura, Yasushi
Subject
voltage sensor
voltage-gated proton channel
topology
Abstract
The voltage-sensor domain (VSD) is the key module for voltage sensing of transmembrane proteins. Recently, voltage-sensor only protein (VSOP) that contains a single VSD but no pore domain was discovered and functions as the voltage-gated proton channel. The fourth transmembrane segment (S4) of VSOP contains three arginines (R1, R2, R3). We found that VSOP truncated just downstream of R2 retains most channel properties. Two assays, PEGylation-protection assay and membrane insertion assay, showed that S4 inserts into the membrane, even if it is truncated between R2 and R3. These findings provide important clues to the molecular mechanism of voltage-gated proton channel.
Publisher
日本生物物理学会
The Biophysical Society of Japan
ニホン　セイブツ　ブツリ　ガッカイ
Source Title
生物物理
Volume (Issue)
51(2)
Page
072-075
Date of Issued
2011-03-25
Language
Japanese
Handle URL
https://hdl.handle.net/11094/23166
PISSN
05824052
NCID
AN00129693
Relation.references
URI
https://www.jstage.jst.go.jp/article/biophys/51/2/51_2_072/_article/-char/ja/
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.2142/biophys.51.072
Access Rights
open access
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article