A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling

久保, 盾貴

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Identifier to cite or link to this item: https://hdl.handle.net/11094/3294

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Title
A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
新規のFERM Domain Including Guanine Nucleotide Exchange FactorはRacのシグナルを介し神経軸索の伸展を制御する
シンキ　ノ　FERM Domain Including Guanine Nucleotide Exchange FactorはRac　ノ　シグナル　ヲ　カイシ　シンケイ　ジクサク　ノ　ソシンテン　ヲ　セイギョ　スル
Creator
NRID
1000000362707 1000000362707
ORCID
0000-0003-1402-5383 0000-0003-1402-5383
researchmap permalink
read0106283 read0106283
Scopus Author ID
55600046500 55600046500
CreatorName
久保, 盾貴 ; クボ, タテキ
Description
Kubo, Tateki; Yamashita, Toshihide; Yamaguchi, Atsushi; Sumimoto, Hideki; Hosokawa, Ko; Tohyama, Masaya. A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling. Journal of Neuroscience. 2002. 22(19), p.8504-8513.
Abstract
The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells from yeast to human, is implicated in the control of neuronal morphology. Guanine nucleotide exchange factors (GEFs) are upstream positive regulators of Rho GTPases and integrate extracellular signaling for appropriate activation of Rho GTPases at specific subcellular regions. Here we describe the identification of a novel Dbl family GEF for Rho GTPases in Homo sapiens and Mus musculus. It contains a tandem Dbl homology-pleckstrin homology domain and FERM domain, characteristic of the plasma membrane proteins linker. This gene, termed FERM domain including RhoGEF (FIR), was abundantly expressed in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons. FIR was found to activate the biochemical pathway specific for Rac1 but not for RhoA or Cdc42. Ectopic expression of FIR in the cortical neurons resulted in significantly shortened neurites and excessive growth cones, presumably mediated by Rac1. These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac.
Degree Name
博士（医学）
Date of Granted
2004-06-23
Grantor
Osaka University
Faculty
医学系
Grant ID
乙第08910号
Description Number
18946
Language
English
Handle URL
https://hdl.handle.net/11094/3294
Relation.references
URI
http://www.jneurosci.org/cgi/content/abstract/22/19/8504
Access Rights
open access
CopyRight
Copyright: Society for Neuroscience
oaire:version
Version of Record
Category
Doctoral Thesis with Full Text / Graduate School of Medicine / 2004
Doctoral Thesis / Graduate School of Medicine / 2004