3D-Human Tissue Chips Fabricated by Inkjet Cell Printing

Matsusaki, Michiya; Akashi, Mitsuru

Journal of the Imaging Society of Japan, 2012, 51(5), 524-530

Number of Access:640（2025-08-27 19:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/50628

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Title
3D-Human Tissue Chips Fabricated by Inkjet Cell Printing
Creator
NRID
1000000419467 1000000419467
researchmap permalink
read0093431 read0093431
Scopus Author ID
6701561701 6701561701
CreatorName
Matsusaki, Michiya
NRID
1000020145460 1000020145460
researchmap permalink
read0094016 read0094016
Scopus Author ID
35463476100 35463476100
CreatorName
Akashi, Mitsuru
Subject
Inkjet printing
Cells
Human tissue chip
Pharmaceutical assay
Abstract
We demonstrate a LbL assembly using the inkjet printing of single cells and proteins to enable the fabrication of 3D human micro-tissue arrays, which are integrated structures of micrometer-sized cellular multilayers controlled at the single-cell layer level, for application of pharmaceutical assays. Introduction of automatic inkjet printing of cells and proteins must be necessary for giving an assurance of their reproducibility. The 440 microarrays which were the integration of simplified and multilayered liver structures were successfully developed and comprehensive high-throughput assays of liver functions were performed. We found for the first time that these simplified 3D liver structures, a sandwich of endothelial cells and hepatocytes, revealed the highest functions as compared to other 3D-structures. These 3D-human tissue chips would enable the "total-human tissue models" for tailor-made drug screening.
Publisher
日本画像学会
ニホン　ガゾウ　ガッカイ
Source Title
Journal of the Imaging Society of Japan
Volume (Issue)
51(5)
Page
524-530
Date of Issued
2012
Language
English
Handle URL
https://hdl.handle.net/11094/50628
PISSN
13444425
NCID
AA1137305X
Access Rights
open access
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article