Stop-and-go kinetics in amyloid fibrillation

Ferkinghoff-Borg, Jesper; Fonslet, Jesper; Andersen, Christian Beyschau; Krishna, Sandeep; Pigolotti, Simone; Yagi, Hisashi; Goto, Yuji; Otzen, Daniel; Jensen, Mogens H.

doi:https://doi.org/10.1103/PhysRevE.82.010901

Stop-and-go kinetics in amyloid fibrillation

Ferkinghoff-Borg, Jesper; Fonslet, Jesper; Andersen, Christian Beyschau et al.

Physical Review E, 2010, 80, 010901

Number of Access:539（2025-08-15 06:44 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/71262

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Title	Stop-and-go kinetics in amyloid fibrillation
Creator	CreatorName Ferkinghoff-Borg, Jesper
	CreatorName Fonslet, Jesper
	CreatorName Andersen, Christian Beyschau
	CreatorName Krishna, Sandeep
	NRID 1000030812193 1000030812193 CreatorName Pigolotti, Simone
	NRID 1000010432494 1000010432494 CreatorName Yagi, Hisashi
	NRID 1000040153770 1000040153770 researchmap permalink read0014440 read0014440 CreatorName Goto, Yuji
	CreatorName Otzen, Daniel
	CreatorName Jensen, Mogens H.
Description	Jesper Ferkinghoff-Borg, Jesper Fonslet, Christian Beyschau Andersen, Sandeep Krishna, Simone Pigolotti, Hisashi Yagi, Yuji Goto, Daniel Otzen, and Mogens H. Jensen "Stop-and-go kinetics in amyloid fibrillation", Physical Review E, 82, 010901, American Physical Society, 2010
Abstract	Many human diseases are associated with protein aggregation and fibrillation. We present experiments on in vitro glucagon fibrillation using total internal reflection fluorescence microscopy, providing real-time measurements of single-fibril growth. We find that amyloid fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. The observed exponential distributions of stop and growth times support a Markovian model, in which fibrils shift between the two states with specific rates. Even if the individual rates vary considerably, we observe that the probability of being in the growing (stopping) state is very close to 1/4 (3/4) in all experiments.
Publisher	American Physical Society
Source Title	Physical Review E
Volume (Issue)	80
Page	010901
Date of Issued	2010-07
Language	English
Handle URL	https://hdl.handle.net/11094/71262
PISSN	24700045
NCID	AA11558033
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1103/PhysRevE.82.010901
Access Rights	open access
CopyRight	© 2010 The American Physical Society
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Physical Review E. 2010, 80, p. 010901
DC.title	Stop-and-go kinetics in amyloid fibrillation
DC.creator	Ferkinghoff-Borg, Jesper
	Fonslet, Jesper
	Andersen, Christian Beyschau
	Krishna, Sandeep
	Pigolotti, Simone
	Yagi, Hisashi
	Goto, Yuji
	Otzen, Daniel
	Jensen, Mogens H.
DC.publisher	American Physical Society
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2010-07
DC.identifier	https://doi.org/10.1103/PhysRevE.82.010901
DC.description	Jesper Ferkinghoff-Borg, Jesper Fonslet, Christian Beyschau Andersen, Sandeep Krishna, Simone Pigolotti, Hisashi Yagi, Yuji Goto, Daniel Otzen, and Mogens H. Jensen "Stop-and-go kinetics in amyloid fibrillation", Physical Review E, 82, 010901, American Physical Society, 2010
DCTERMS.abstract	Many human diseases are associated with protein aggregation and fibrillation. We present experiments on in vitro glucagon fibrillation using total internal reflection fluorescence microscopy, providing real-time measurements of single-fibril growth. We find that amyloid fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. The observed exponential distributions of stop and growth times support a Markovian model, in which fibrils shift between the two states with specific rates. Even if the individual rates vary considerably, we observe that the probability of being in the growing (stopping) state is very close to 1/4 (3/4) in all experiments.
DC.rights	© 2010 The American Physical Society
DC.format	71262
citation_title	Stop-and-go kinetics in amyloid fibrillation
citation_author	Ferkinghoff-Borg, Jesper
	Fonslet, Jesper
	Andersen, Christian Beyschau
	Krishna, Sandeep
	Pigolotti, Simone
	Yagi, Hisashi
	Goto, Yuji
	Otzen, Daniel
	Jensen, Mogens H.
citation_publisher	American Physical Society
citation_language	English
citation_date	2010-07
citation_journal_title	Physical Review E
citation_volume	80
citation_firstpage	010901
citation_doi	https://doi.org/10.1103/PhysRevE.82.010901
citation_public_url	https://hdl.handle.net/11094/71262

Stop-and-go kinetics in amyloid fibrillation

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