Nucleus factory on cavitation bubble for amyloid β fibril

Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

doi:https://doi.org/10.1038/srep22015

Nucleus factory on cavitation bubble for amyloid β fibril

Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta et al.

Scientific Reports, 2016, 6, 22015

Number of Access:725（2025-08-01 03:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/71267

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Title	Nucleus factory on cavitation bubble for amyloid β fibril
Creator	NRID 1000020867337 1000020867337 ORCID 0000-0003-2644-741X 0000-0003-2644-741X researchmap permalink sonochem sonochem Scopus Author ID 57145904700 57145904700 CreatorName Nakajima, Kichitaro
	NRID 1000090252626 1000090252626 researchmap permalink read0042771 read0042771 Scopus Author ID 35563683500 35563683500 CreatorName Ogi, Hirotsugu
	NRID 1000050823879 1000050823879 ORCID 0000-0002-5321-3777 0000-0002-5321-3777 researchmap permalink kantaadachi kantaadachi Scopus Author ID 57146267500 57146267500 CreatorName Adachi, Kanta
	NRID 1000030588405 1000030588405 CreatorName Noi, Kentaro
	NRID 1000080112027 1000080112027 CreatorName Hirao, Masahiko
	NRID 1000010432494 1000010432494 CreatorName Yagi, Hisashi
	NRID 1000040153770 1000040153770 researchmap permalink read0014440 read0014440 CreatorName Goto, Yuji
Description	Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi & Yuji Goto "Nucleus factory on cavitation bubble for amyloid β fibril", Scientific Reports, volume 6, Article number: 22015, Springer Nature, 2016
Abstract	Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.
Publisher	Springer Nature
Source Title	Scientific Reports
Volume (Issue)	6
Page	22015
Date of Issued	2016-02
Language	English
Handle URL	https://hdl.handle.net/11094/71267
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/srep22015
Access Rights	open access
CopyRight	© 2016 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2016, 6, p. 22015
DC.title	Nucleus factory on cavitation bubble for amyloid β fibril
DC.creator	Nakajima, Kichitaro
	Ogi, Hirotsugu
	Adachi, Kanta
	Noi, Kentaro
	Hirao, Masahiko
	Yagi, Hisashi
	Goto, Yuji
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2016-02
DC.identifier	https://doi.org/10.1038/srep22015
DC.description	Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi & Yuji Goto "Nucleus factory on cavitation bubble for amyloid β fibril", Scientific Reports, volume 6, Article number: 22015, Springer Nature, 2016
DCTERMS.abstract	Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.
DC.rights	© 2016 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	71267
citation_title	Nucleus factory on cavitation bubble for amyloid β fibril
citation_author	Nakajima, Kichitaro
	Ogi, Hirotsugu
	Adachi, Kanta
	Noi, Kentaro
	Hirao, Masahiko
	Yagi, Hisashi
	Goto, Yuji
citation_publisher	Springer Nature
citation_language	English
citation_date	2016-02
citation_journal_title	Scientific Reports
citation_volume	6
citation_firstpage	22015
citation_doi	https://doi.org/10.1038/srep22015
citation_public_url	https://hdl.handle.net/11094/71267

Nucleus factory on cavitation bubble for amyloid β fibril

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