β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

Fujioka, Teppei; Kaneko, Naoko; Ajioka, Itsuki; Nakaguchi, Kanako; Omata, Taichi; Ohba, Honoka; Fässler, Reinhard; García-Verdugo, José Manuel; Sekiguchi, Kiyotoshi; Matsukawa, Noriyuki; Sawamoto, Kazunobu

doi:https://doi.org/10.1016/j.ebiom.2017.01.005

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

Fujioka, Teppei; Kaneko, Naoko; Ajioka, Itsuki et al.

EBioMedicine, 2017, 16, 195-203

Number of Access:746（2025-08-18 14:26 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/71814

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Title	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
Creator	CreatorName Fujioka, Teppei
	NRID 1000020464571 1000020464571 CreatorName Kaneko, Naoko
	NRID 1000010348790 1000010348790 CreatorName Ajioka, Itsuki
	CreatorName Nakaguchi, Kanako
	CreatorName Omata, Taichi
	CreatorName Ohba, Honoka
	CreatorName Fässler, Reinhard
	CreatorName García-Verdugo, José Manuel
	NRID 1000050187845 1000050187845 researchmap permalink read0054833 read0054833 Scopus Author ID 7201662709 7201662709 ORCID 0000-0002-6433-1410 0000-0002-6433-1410 CreatorName Sekiguchi, Kiyotoshi
	NRID 1000020305543 1000020305543 CreatorName Matsukawa, Noriyuki
	NRID 1000090282350 1000090282350 CreatorName Sawamoto, Kazunobu
Subject	β1 integrin
	Laminin
	Blood vessel
	Chain migration
	Vasculature-guided migration
	Stroke
Description	Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, and Kazunobu Sawamoto, "β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain", EBioMedicine, 16, 195-203, Elsevier, 2017
Abstract	Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatmentto promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, im-mature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricularzone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increasethe number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for is-chemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficientneuronal regeneration. To move toward the lesion, neuroblasts form chain-like aggregates and migrate alongblood vessels, which are thought to increase their migration efficiency. However, the molecular mechanisms reg-ulating thesemigration processesare largely unknown. Here we studied the role ofβ1-class integrins, transmem-brane receptors for extracellular matrix proteins, in these migrating neuroblasts. We found that the neuroblastchain formation and blood vessel-guided migration critically depend onβ1 integrin signaling.β1 integrin facili-tated the adhesion of neuroblasts to laminin and the efficient translocation of their soma during migration. More-over, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward theinjured area. These data suggest that laminin signaling viaβ1 integrin supports vasculature-guided neuronal mi-gration to efficiently supply neuroblasts to injured areas. This study also highlights the importance of vascularscaffolds for cell migration in development and regeneration.
Publisher	Elsevier
Source Title	EBioMedicine
Volume (Issue)	16
Page	195-203
Date of Issued	2017-02
Language	English
Handle URL	https://hdl.handle.net/11094/71814
eISSN	23523964
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.ebiom.2017.01.005
Access Rights	open access
CopyRight	© 2017 The Author(s). Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	EBioMedicine. 2017, 16, p. 195-203
DC.title	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
DC.creator	Fujioka, Teppei
	Kaneko, Naoko
	Ajioka, Itsuki
	Nakaguchi, Kanako
	Omata, Taichi
	Ohba, Honoka
	Fässler, Reinhard
	García-Verdugo, José Manuel
	Sekiguchi, Kiyotoshi
	Matsukawa, Noriyuki
	Sawamoto, Kazunobu
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2017-02
DC.identifier	https://doi.org/10.1016/j.ebiom.2017.01.005
DC.subject	β1 integrin
	Laminin
	Blood vessel
	Chain migration
	Vasculature-guided migration
	Stroke
DC.description	Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, and Kazunobu Sawamoto, "β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain", EBioMedicine, 16, 195-203, Elsevier, 2017
DCTERMS.abstract	Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatmentto promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, im-mature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricularzone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increasethe number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for is-chemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficientneuronal regeneration. To move toward the lesion, neuroblasts form chain-like aggregates and migrate alongblood vessels, which are thought to increase their migration efficiency. However, the molecular mechanisms reg-ulating thesemigration processesare largely unknown. Here we studied the role ofβ1-class integrins, transmem-brane receptors for extracellular matrix proteins, in these migrating neuroblasts. We found that the neuroblastchain formation and blood vessel-guided migration critically depend onβ1 integrin signaling.β1 integrin facili-tated the adhesion of neuroblasts to laminin and the efficient translocation of their soma during migration. More-over, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward theinjured area. These data suggest that laminin signaling viaβ1 integrin supports vasculature-guided neuronal mi-gration to efficiently supply neuroblasts to injured areas. This study also highlights the importance of vascularscaffolds for cell migration in development and regeneration.
DC.rights	© 2017 The Author(s). Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	71814
citation_title	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
citation_author	Fujioka, Teppei
	Kaneko, Naoko
	Ajioka, Itsuki
	Nakaguchi, Kanako
	Omata, Taichi
	Ohba, Honoka
	Fässler, Reinhard
	García-Verdugo, José Manuel
	Sekiguchi, Kiyotoshi
	Matsukawa, Noriyuki
	Sawamoto, Kazunobu
citation_publisher	Elsevier
citation_language	English
citation_date	2017-02
citation_journal_title	EBioMedicine
citation_volume	16
citation_firstpage	195
citation_lastpage	203
citation_doi	https://doi.org/10.1016/j.ebiom.2017.01.005
citation_public_url	https://hdl.handle.net/11094/71814

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

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