Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study

Ikeda, Sayaka; Ueda, Yutaka; Hara, Megumi; Yagi, Asami; Kitamura, Tetsuhisa; Kitamura, Yuri; Konishi, Hiroshi; Kakizoe, Tadao; Sekine, Masayuki; Enomoto, Takayuki; Sobue, Tomotaka

doi:https://doi.org/10.1111/cas.14682

Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study

Ikeda, Sayaka; Ueda, Yutaka; Hara, Megumi et al.

Cancer Science, 2020, 112(2), 839-846

Number of Access:1,395（2025-08-15 22:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78265

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
cas_2020_14682	pdf	None	776 KB	286	2021.01.14

Creative Commons : Attribution - NonCommercial - NoDerivatives

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study
Creator	CreatorName Ikeda, Sayaka
	NRID 1000010346215 1000010346215 ORCID 0000-0001-8760-6379 0000-0001-8760-6379 researchmap permalink read0092318 read0092318 Scopus Author ID 55087087500 55087087500 CreatorName Ueda, Yutaka
	NRID 1000090336115 1000090336115 CreatorName Hara, Megumi
	NRID 1000030793450 1000030793450 researchmap permalink 2018101510006244 2018101510006244 Scopus Author ID 56244059700 56244059700 CreatorName Yagi, Asami
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 CreatorName Kitamura, Tetsuhisa
	NRID 1000090294074 1000090294074 CreatorName Kitamura, Yuri
	CreatorName Konishi, Hiroshi
	CreatorName Kakizoe, Tadao
	NRID 1000070345502 1000070345502 CreatorName Sekine, Masayuki
	NRID 1000090283754 1000090283754 CreatorName Enomoto, Takayuki
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 CreatorName Sobue, Tomotaka
Subject	case-control study
	cervical intraepithelial neoplasia
	HPV vaccine
	human papillomavirus
	vaccine effectiveness
Description	Ikeda, S, Ueda, Y, Hara, M, et al. Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case‐control study. Cancer Sci. 2020; 00: 1– 8. https://doi.org/10.1111/cas.14682.
Abstract	Cervical cancer remains among the most common cancers in women worldwide and can be prevented by vaccination. The Ministry of Health, Labour and Welfare of Japan suspended active recommendation of regular human papillomavirus (HPV) vaccines in 2013 because of various symptoms including chronic pain and motor impairment. This nationwide case-control study from April 2013 to March 2017 targeted women aged 20-24 years old at cervical screening. We compared HPV vaccination exposure between those with abnormal and normal cytology. Abnormal cytology was classified based on the results of histological test and we calculated the odds ratio (OR) and 95% confidence interval (CI) of the above endpoints and vaccination exposure using the conditional logistic regression model and estimated vaccine effectiveness using the formula (1 – OR) × 100. A total of 2483 cases and 12 296 controls (one-to-five matching) were eligible in 31 municipalities in Japan. The distribution of histological abnormalities among cases was 797 CIN1 (including dysplasia) (32.1%), 165 CIN2 (6.7%), 44 CIN3 (1.8%), and eight squamous cell carcinoma (SCC) (0.3%). The OR of HPV vaccination compared with no vaccination for abnormal cytology, CIN1+, CIN2+, and CIN3+ versus controls was 0.42 (95% CI, 0.34-0.50), 0.42 (95% CI, 0.31-0.58), 0.25 (95% CI, 0.12-0.54), and 0.19 (95% CI, 0.03-1.15), respectively, equating to a vaccine effectiveness of 58.5%, 57.9%, 74.8%, and 80.9%, respectively. Eight patients had SCC, none was vaccinated. This nationwide case-control study in Japan demonstrated a substantial risk reduction in abnormal cytology and CIN among women who did versus those who did not receive HPV vaccination.
Publisher	Blackwell Publishing Ltd
Source Title	Cancer Science
Volume (Issue)	112(2)
Page	839-846
Date of Issued	2020-10-10
Language	English
Handle URL	https://hdl.handle.net/11094/78265
PISSN	13479032
eISSN	13497006
NCID	AA12100165
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/cas.14682
Relation.isIdenticalTo	PMID 33040433
Access Rights	open access
CopyRight	© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Cancer Science. 2020, 112(2), p. 839-846
DC.title	Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study
DC.creator	Ikeda, Sayaka
	Ueda, Yutaka
	Hara, Megumi
	Yagi, Asami
	Kitamura, Tetsuhisa
	Kitamura, Yuri
	Konishi, Hiroshi
	Kakizoe, Tadao
	Sekine, Masayuki
	Enomoto, Takayuki
	Sobue, Tomotaka
DC.publisher	Blackwell Publishing Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-10-10
DC.identifier	https://doi.org/10.1111/cas.14682
DC.subject	case-control study
	cervical intraepithelial neoplasia
	HPV vaccine
	human papillomavirus
	vaccine effectiveness
DC.description	Ikeda, S, Ueda, Y, Hara, M, et al. Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case‐control study. Cancer Sci. 2020; 00: 1– 8. https://doi.org/10.1111/cas.14682.
DCTERMS.abstract	Cervical cancer remains among the most common cancers in women worldwide and can be prevented by vaccination. The Ministry of Health, Labour and Welfare of Japan suspended active recommendation of regular human papillomavirus (HPV) vaccines in 2013 because of various symptoms including chronic pain and motor impairment. This nationwide case-control study from April 2013 to March 2017 targeted women aged 20-24 years old at cervical screening. We compared HPV vaccination exposure between those with abnormal and normal cytology. Abnormal cytology was classified based on the results of histological test and we calculated the odds ratio (OR) and 95% confidence interval (CI) of the above endpoints and vaccination exposure using the conditional logistic regression model and estimated vaccine effectiveness using the formula (1 – OR) × 100. A total of 2483 cases and 12 296 controls (one-to-five matching) were eligible in 31 municipalities in Japan. The distribution of histological abnormalities among cases was 797 CIN1 (including dysplasia) (32.1%), 165 CIN2 (6.7%), 44 CIN3 (1.8%), and eight squamous cell carcinoma (SCC) (0.3%). The OR of HPV vaccination compared with no vaccination for abnormal cytology, CIN1+, CIN2+, and CIN3+ versus controls was 0.42 (95% CI, 0.34-0.50), 0.42 (95% CI, 0.31-0.58), 0.25 (95% CI, 0.12-0.54), and 0.19 (95% CI, 0.03-1.15), respectively, equating to a vaccine effectiveness of 58.5%, 57.9%, 74.8%, and 80.9%, respectively. Eight patients had SCC, none was vaccinated. This nationwide case-control study in Japan demonstrated a substantial risk reduction in abnormal cytology and CIN among women who did versus those who did not receive HPV vaccination.
DC.rights	© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	78265
citation_title	Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study
citation_author	Ikeda, Sayaka
	Ueda, Yutaka
	Hara, Megumi
	Yagi, Asami
	Kitamura, Tetsuhisa
	Kitamura, Yuri
	Konishi, Hiroshi
	Kakizoe, Tadao
	Sekine, Masayuki
	Enomoto, Takayuki
	Sobue, Tomotaka
citation_publisher	Blackwell Publishing Ltd
citation_language	English
citation_date	2020-10-10
citation_journal_title	Cancer Science
citation_volume	112
citation_issue	2
citation_firstpage	839
citation_lastpage	846
citation_doi	https://doi.org/10.1111/cas.14682
citation_pmid	33040433
citation_public_url	https://hdl.handle.net/11094/78265

Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study

Link to primary information

Item Information

Show details