A four-dimensional organoid system to visualize cancer cell vascular invasion

Yanagisawa, Kiminori; Konno, Masamitsu; Liu, Hao et al.

Biology, 2020, 9(11), 361

Number of Access:1,150（2025-08-14 01:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78290

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
biology_09_11_361 pdf None 27.2 MB 173 2021.01.15  
Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title
A four-dimensional organoid system to visualize cancer cell vascular invasion
Creator
CreatorName
Yanagisawa, Kiminori
NRID
1000080618207 1000080618207
CreatorName
Konno, Masamitsu
CreatorName
Liu, Hao
CreatorName
Irie, Shinji
NRID
1000000527707 1000000527707
researchmap permalink
tmizushima tmizushima
Scopus Author ID
36876092000 36876092000
CreatorName
Mizushima, Tsunekazu
NRID
1000070190999 1000070190999
CreatorName
Mori, Masaki
NRID
1000020291445 1000020291445
researchmap permalink
ydoki3251 ydoki3251
Scopus Author ID
7006390687 7006390687
CreatorName
Doki, Yuichiro
NRID
1000090542118 1000090542118
researchmap permalink
abcdabcdabcd abcdabcdabcd
Scopus Author ID
7101627772 7101627772
CreatorName
Eguchi, Hidetoshi
NRID
1000000419467 1000000419467
researchmap permalink
read0093431 read0093431
Scopus Author ID
6701561701 6701561701
CreatorName
Matsusaki, Michiya
NRID
1000010280736 1000010280736
researchmap permalink
read0103186 read0103186
Scopus Author ID
7402978600 7402978600
CreatorName
Ishii, Hideshi
Subject
4D culture
Exosome
Mimic model
Tight junction
Vascular invasion
Vascular organoid
Description
Yanagisawa, K.; Konno, M.; Liu, H.; Irie, S.; Mizushima, T.; Mori, M.; Doki, Y.; Eguchi, H.; Matsusaki, M.; Ishii, H. A Four-Dimensional Organoid System to Visualize Cancer Cell Vascular Invasion. Biology 2020, 9, 361.
Abstract
Vascular invasion of cancer is a critical step in cancer progression, but no drug has been developed to inhibit vascular invasion. To achieve the eradication of cancer metastasis, elucidation of the mechanism for vascular invasion and the development of innovative treatment methods are required. Here, a simple and reproducible vascular invasion model is established using a vascular organoid culture in a fibrin gel with collagen microfibers. Using this model, it was possible to observe and evaluate the cell dynamics and histological positional relationship of invasive cancer cells in four dimensions. Cancer-derived exosomes promoted the vascular invasion of cancer cells and loosened tight junctions in the vascular endothelium. As a new evaluation method, research using this vascular invasion mimic model will be advanced, and applications to the evaluation of the vascular invasion suppression e_ect of a drug are expected.
Publisher
MDPI
Source Title
Biology
Volume (Issue)
9(11)
Page
361
Date of Issued
2020-11
Language
English
Handle URL
https://hdl.handle.net/11094/78290
eISSN
20797737
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/biology9110361
Access Rights
open access
CopyRight
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article