Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism

Saiki, Aya; Otsuki, Michio; Tamada, Daisuke; Kitamura, Tetsuhiro; Shimomura, Iichiro; Kurihara, Isao; Ichijo, Takamasa; Takeda, Yoshiyu; Katabami, Takuyuki; Tsuiki, Mika; Wada, Norio; Yanase, Toshihiko; Ogawa, Yoshihiro; Kawashima, Junji; Sone, Masakatsu; Inagaki, Nobuya; Yoshimoto, Takanobu; Okamoto, Ryuji; Takahashi, Katsutoshi; Kobayashi, Hiroki; Tamura, Kouichi; Kamemura, Kohei; Yamamoto, Koichi; Izawa, Shoichiro; Kakutani, Miki; Yamada, Masanobu; Tanabe, Akiyo; Naruse, Mitsuhide

doi:https://doi.org/10.1210/clinem/dgaa177

Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism

Saiki, Aya; Otsuki, Michio; Tamada, Daisuke et al.

Journal of Clinical Endocrinology and Metabolism, 2020, 105(7), e2531-e2537

Number of Access:3,666（2025-07-18 10:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78291

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Title	Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism
Creator	CreatorName Saiki, Aya
	NRID 1000000403056 1000000403056 CreatorName Otsuki, Michio
	CreatorName Tamada, Daisuke
	NRID 1000020470198 1000020470198 CreatorName Kitamura, Tetsuhiro
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
	NRID 1000090338038 1000090338038 CreatorName Kurihara, Isao
	CreatorName Ichijo, Takamasa
	NRID 1000090242544 1000090242544 CreatorName Takeda, Yoshiyu
	NRID 1000070257369 1000070257369 CreatorName Katabami, Takuyuki
	CreatorName Tsuiki, Mika
	CreatorName Wada, Norio
	NRID 1000030239818 1000030239818 CreatorName Yanase, Toshihiko
	NRID 1000070291424 1000070291424 CreatorName Ogawa, Yoshihiro
	NRID 1000070467984 1000070467984 CreatorName Kawashima, Junji
	NRID 1000040437207 1000040437207 CreatorName Sone, Masakatsu
	NRID 1000030241954 1000030241954 CreatorName Inagaki, Nobuya
	NRID 1000080297457 1000080297457 CreatorName Yoshimoto, Takanobu
	NRID 1000060378346 1000060378346 CreatorName Okamoto, Ryuji
	CreatorName Takahashi, Katsutoshi
	CreatorName Kobayashi, Hiroki
	NRID 1000040285143 1000040285143 CreatorName Tamura, Kouichi
	CreatorName Kamemura, Kohei
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 CreatorName Yamamoto, Koichi
	NRID 1000030572599 1000030572599 CreatorName Izawa, Shoichiro
	CreatorName Kakutani, Miki
	NRID 1000090261833 1000090261833 CreatorName Yamada, Masanobu
	NRID 1000000236655 1000000236655 CreatorName Tanabe, Akiyo
	NRID 1000040120018 1000040120018 CreatorName Naruse, Mitsuhide
Subject	Cardio-cerebrovascular events
	Diabetes mellitus
	EGFR
	Primary aldosteronism
	Proteinuria
Description	This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Aya Saiki, Michio Otsuki, Daisuke Tamada, Tetsuhiro Kitamura, Iichiro Shimomura, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Toshihiko Yanase, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse, Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 7, July 2020, Pages e2531–e2537 is available online at: https://doi.org/10.1210/clinem/dgaa177.
Abstract	Context: The prevalence of diabetes mellitus (DM) in patients with primary aldosteronism (PA) is higher than in those with essential hypertension and the general population. Although DM is a common major risk factor for cardio-cerebrovascular (CCV) diseases and renal complications, details of its effects in PA have not been demonstrated. Objective: The aim of this study was to determine the effects of coexistent DM on the risk of CCV events and progression of renal complications in PA patients. Design: A multi-institutional, cross-sectional study was conducted. Patients and Methods: PA patients experienced between January 2006 and October 2016 and with available data of CCV events and DM were enrolled from the Japan PA registry of the Japan Primary Aldosteronism Study/Japan Rare Intractable Adrenal Diseases Study (n = 2524). CCV events and renal complications were compared between a DM group and a non-DM group by logistic and liner-regression analysis. Results: DM significantly increased the odds ratio (OR) of CCV events (OR 1.59, 95% CI: 1.05- 2.41) and that of proteinuria (OR 2.25, 95% CI: 1.59-3.16). DM correlated significantly with declines in estimated glomerular filtration rate (β = .05, P = .02). Conclusions: This the first report to demonstrate the presence of DM as an independent risk factor for CCV events and renal complications, even in PA patients. Management of DM should be considered in addition to the specific treatment of PA.
Publisher	Endocrine Society
Source Title	Journal of Clinical Endocrinology and Metabolism
Volume (Issue)	105(7)
Page	e2531-e2537
Date of Issued	2020-07
Language	English
Handle URL	https://hdl.handle.net/11094/78291
PISSN	0021972X
eISSN	19457197
NCID	AA00695484
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1210/clinem/dgaa177
Access Rights	open access
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Clinical Endocrinology and Metabolism. 2020, 105(7), p. e2531-e2537
DC.title	Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism
DC.creator	Saiki, Aya
	Otsuki, Michio
	Tamada, Daisuke
	Kitamura, Tetsuhiro
	Shimomura, Iichiro
	Kurihara, Isao
	Ichijo, Takamasa
	Takeda, Yoshiyu
	Katabami, Takuyuki
	Tsuiki, Mika
	Wada, Norio
	Yanase, Toshihiko
	Ogawa, Yoshihiro
	Kawashima, Junji
	Sone, Masakatsu
	Inagaki, Nobuya
	Yoshimoto, Takanobu
	Okamoto, Ryuji
	Takahashi, Katsutoshi
	Kobayashi, Hiroki
	Tamura, Kouichi
	Kamemura, Kohei
	Yamamoto, Koichi
	Izawa, Shoichiro
	Kakutani, Miki
	Yamada, Masanobu
	Tanabe, Akiyo
	Naruse, Mitsuhide
DC.publisher	Endocrine Society
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-07
DC.identifier	https://doi.org/10.1210/clinem/dgaa177
DC.subject	Cardio-cerebrovascular events
	Diabetes mellitus
	EGFR
	Primary aldosteronism
	Proteinuria
DC.description	This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Aya Saiki, Michio Otsuki, Daisuke Tamada, Tetsuhiro Kitamura, Iichiro Shimomura, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Toshihiko Yanase, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse, Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 7, July 2020, Pages e2531–e2537 is available online at: https://doi.org/10.1210/clinem/dgaa177.
DCTERMS.abstract	Context: The prevalence of diabetes mellitus (DM) in patients with primary aldosteronism (PA) is higher than in those with essential hypertension and the general population. Although DM is a common major risk factor for cardio-cerebrovascular (CCV) diseases and renal complications, details of its effects in PA have not been demonstrated. Objective: The aim of this study was to determine the effects of coexistent DM on the risk of CCV events and progression of renal complications in PA patients. Design: A multi-institutional, cross-sectional study was conducted. Patients and Methods: PA patients experienced between January 2006 and October 2016 and with available data of CCV events and DM were enrolled from the Japan PA registry of the Japan Primary Aldosteronism Study/Japan Rare Intractable Adrenal Diseases Study (n = 2524). CCV events and renal complications were compared between a DM group and a non-DM group by logistic and liner-regression analysis. Results: DM significantly increased the odds ratio (OR) of CCV events (OR 1.59, 95% CI: 1.05- 2.41) and that of proteinuria (OR 2.25, 95% CI: 1.59-3.16). DM correlated significantly with declines in estimated glomerular filtration rate (β = .05, P = .02). Conclusions: This the first report to demonstrate the presence of DM as an independent risk factor for CCV events and renal complications, even in PA patients. Management of DM should be considered in addition to the specific treatment of PA.
DC.format	78291
citation_title	Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism
citation_author	Saiki, Aya
	Otsuki, Michio
	Tamada, Daisuke
	Kitamura, Tetsuhiro
	Shimomura, Iichiro
	Kurihara, Isao
	Ichijo, Takamasa
	Takeda, Yoshiyu
	Katabami, Takuyuki
	Tsuiki, Mika
	Wada, Norio
	Yanase, Toshihiko
	Ogawa, Yoshihiro
	Kawashima, Junji
	Sone, Masakatsu
	Inagaki, Nobuya
	Yoshimoto, Takanobu
	Okamoto, Ryuji
	Takahashi, Katsutoshi
	Kobayashi, Hiroki
	Tamura, Kouichi
	Kamemura, Kohei
	Yamamoto, Koichi
	Izawa, Shoichiro
	Kakutani, Miki
	Yamada, Masanobu
	Tanabe, Akiyo
	Naruse, Mitsuhide
citation_publisher	Endocrine Society
citation_language	English
citation_date	2020-07
citation_journal_title	Journal of Clinical Endocrinology and Metabolism
citation_volume	105
citation_issue	7
citation_firstpage	e2531
citation_lastpage	e2537
citation_doi	https://doi.org/10.1210/clinem/dgaa177
citation_public_url	https://hdl.handle.net/11094/78291

Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism

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