Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment

Kawachi, Yusuke; Fujishima, Yuya; Nishizawa, Hitoshi; Nagao, Hirofumi; Nakamura, Takashi; Akari, Seigo; Murase, Takayo; Taya, Naohiro; Omori, Kazuo; Miyake, Akimitsu; Fukuda, Shiro; Takahara, Mitsuyoshi; Kita, Shunbun; Katakami, Naoto; Maeda, Norikazu; Shimomura, Iichiro

doi:https://doi.org/10.1111/jdi.13467

Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment

Kawachi, Yusuke; Fujishima, Yuya; Nishizawa, Hitoshi et al.

Journal of Diabetes Investigation, 2020, 12(8), 1512-1520

Number of Access:2,123（2025-07-18 09:46 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/78312

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Title	Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment
Creator	CreatorName Kawachi, Yusuke
	NRID 1000010779789 1000010779789 researchmap permalink Yuya_Fujishima Yuya_Fujishima Scopus Author ID 54410318600 54410318600 CreatorName Fujishima, Yuya
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	CreatorName Nagao, Hirofumi
	CreatorName Nakamura, Takashi
	CreatorName Akari, Seigo
	CreatorName Murase, Takayo
	CreatorName Taya, Naohiro
	CreatorName Omori, Kazuo
	CreatorName Miyake, Akimitsu
	NRID 1000000896467 1000000896467 CreatorName Fukuda, Shiro
	NRID 1000000751067 1000000751067 researchmap permalink takahara-mitsuyoshi takahara-mitsuyoshi Scopus Author ID 35933605700 35933605700 CreatorName Takahara, Mitsuyoshi
	NRID 1000010746572 1000010746572 ORCID 0000-0002-8937-0053 0000-0002-8937-0053 researchmap permalink Shunbun_Kita Shunbun_Kita Scopus Author ID 36873116500 36873116500 CreatorName Kita, Shunbun
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 CreatorName Katakami, Naoto
	NRID 1000030506308 1000030506308 researchmap permalink Adiponectin Adiponectin Scopus Author ID 7401561691 7401561691 CreatorName Maeda, Norikazu
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
Subject	Liver transaminases
	Type 2 diabetes mellitus
	Xanthine oxidoreductase
Description	Yusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020.
Abstract	Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type 2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type 2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2 weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1 pmol/h/mL, with a wide range of 14.4–1150 pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type 2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization.
Publisher	Blackwell Publishing
Source Title	Journal of Diabetes Investigation
Volume (Issue)	12(8)
Page	1512-1520
Date of Issued	2020
Language	English
Handle URL	https://hdl.handle.net/11094/78312
PISSN	20401116
eISSN	20401124
NCID	AA12488319
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/jdi.13467
Relation.isIdenticalTo	PMID 33211396
Access Rights	open access
CopyRight	© 2020 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Diabetes Investigation. 2020, 12(8), p. 1512-1520
DC.title	Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment
DC.creator	Kawachi, Yusuke
	Fujishima, Yuya
	Nishizawa, Hitoshi
	Nagao, Hirofumi
	Nakamura, Takashi
	Akari, Seigo
	Murase, Takayo
	Taya, Naohiro
	Omori, Kazuo
	Miyake, Akimitsu
	Fukuda, Shiro
	Takahara, Mitsuyoshi
	Kita, Shunbun
	Katakami, Naoto
	Maeda, Norikazu
	Shimomura, Iichiro
DC.publisher	Blackwell Publishing
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020
DC.identifier	https://doi.org/10.1111/jdi.13467
DC.subject	Liver transaminases
	Type 2 diabetes mellitus
	Xanthine oxidoreductase
DC.description	Yusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020.
DCTERMS.abstract	Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type 2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type 2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2 weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1 pmol/h/mL, with a wide range of 14.4–1150 pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type 2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization.
DC.rights	© 2020 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	78312
citation_title	Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment
citation_author	Kawachi, Yusuke
	Fujishima, Yuya
	Nishizawa, Hitoshi
	Nagao, Hirofumi
	Nakamura, Takashi
	Akari, Seigo
	Murase, Takayo
	Taya, Naohiro
	Omori, Kazuo
	Miyake, Akimitsu
	Fukuda, Shiro
	Takahara, Mitsuyoshi
	Kita, Shunbun
	Katakami, Naoto
	Maeda, Norikazu
	Shimomura, Iichiro
citation_publisher	Blackwell Publishing
citation_language	English
citation_date	2020
citation_journal_title	Journal of Diabetes Investigation
citation_volume	12
citation_issue	8
citation_firstpage	1512
citation_lastpage	1520
citation_doi	https://doi.org/10.1111/jdi.13467
citation_pmid	33211396
citation_public_url	https://hdl.handle.net/11094/78312

Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment

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